Benzimidazole as a Promising Antiviral Heterocyclic Scaffold: A Review

Abstract

Heterocyclic derivatives are unavoidable in many fields of natural disciplines. These derivatives play numerous significant roles in research, medication, and nature. Nitrogenous heterocyclic derivatives extremely are the main target of concern in synthetic chemistry to ensue active natural products with pharmaceuticals and agrochemicals interest. Benzimidazole skeleton is another example of some active heterocyclic moiety that significantly contributes in the numerous bioactive of essential compounds. Benzimidazole skeleton is studied as a prominent moiety of biologically active compounds with various activities including antimicrobial, antiprotozoal, anticancer, antiviral, acetylcholinesterase, antihistaminic, anti-inflammatory, antimalarial, analgesic, anti-HIV and antitubercular. Therefore, in this review we summarize the various antiviral activities of several benzimidazole derivatives and outline the correlation among the structures of different benzimidazoles scaffold with their therapeutic significance.

Seeking heterocyclic scaffolds as antivirals against dengue virus

“…These compounds are vastly explored in various pharmaceutical and agrochemical industries due to their bioactivity [ [105] , [106] , [107] ]. The substituted-imidazole scaffolds display a wide array of biological activity, and these have been explored, like anti-cancer, anti-viral, anti-analgesics, anti-inflammatory, anti-HIV, anti-microbial, and many more [ 105 , [108] , [109] , [110] ].…”

Synthesis, Identification, Computer-Aided Docking Studies, and ADMET Prediction of Novel Benzimidazo-1,2,3-triazole Based Molecules as Potential Antimicrobial Agents

“…Nitrogen-containing heterocyclic analogues have received great interest in drug discovery because of their well-known activity in pharmaceutical and medicinal fields [ 1 , 2 , 3 , 4 ]. Benzimidazole derivatives represent an important heterocyclic class of active therapeutic agents because of their wide spectrum of biological and pharmaceutical applications including antibacterial, antifungal, antiviral, anticancer, antidiabetic, anticonvulsant, and anti-HIV agents [ 5 , 6 ]. In addition, 1,2,3-triazoles have attracted a great deal of interest from medicinal chemists in the design and development of potential drug candidates due to their high pharmacological properties such as antimicrobial, antitubercular, CNS depressant, and antihypertensive activities [ 7 , 8 , 9 , 10 , 11 , 12 ].…”