Benzhydryl and fluorenyl lactamimides with hypoglycemic, diuretic, blood platelet aggregation inhibitory, and antiinflammatory activities

Grisar, J. M.; Claxton, G. P.; Wiech, N. L.; Lucas, Ronald W.; MacKenzie, Robert D.

doi:10.1021/jm00266a005

Cited by 13 publications

(3 citation statements)

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“…143 Adamantyliminopiperidine hydrochlorides 177, which exhibit antiviral and antidiabetic activities, are produced by the reaction of the imidate 6a with adamantylamine hydrochlorides. 144,145 The condensation of 9-aminofluorene (178a) 146,147 or 5-aminodibenzocycloheptane (178b) 147,148 hydrochlorides with the D 1piperideines 6 gives compounds 179a,b, possessing hypoglycemic, 146,147 antiphlogistic, 147,148 anticoagulant and diuretic 146 ± 148 properties.…”

Section: Reactions With Amines and Their Derivativesmentioning

confidence: 99%

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2,3,4,5-Tetrahydropyridine (Δ¹-piperideine) and its derivatives. Synthesis and chemical properties

Shvekhgeimer¹

1998

Russ. Chem. Rev.

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We study the influence of the tetragonalization occurring during the martensitic phase transition on the exchange interactions in Ni 2 MnGa Heusler alloy using first-principles calculations in conjunction with the frozen-magnon approximation. We show that the tetragonalization alters only the exchange constants characterizing the Mn-Mn interactions. Calculated Curie temperatures within the random-phase approximation are found to agree with experimental data. Moreover, we study the temperature dependence of the magnetization and the small deviation from the experimental data exactly at the temperature of the phase transition is discussed. Obtained results agree with previous theoretical results using Liechtenstein's formula to calculate the exchange constants and the Monte Carlo simulation technique to estimate the Curie temperature.have studied the exchange constants for the stoichiometric Ni 2 MnGa alloys for three values of the c/a ratio (c/a = 0.95, 1 and 1.25) using Liechtenstein's formula [31,32] while Monte Carlo simulations have been employed to estimate a Curie temperature of 375 K for the cubic austenitic phase [33]. Recently, the same group of authors have studied the exchange constants for the off-stoichiometric alloys both in the austenitic and martensitic phases [34,35], while Ghosh and Sanyal have focused only in the austenitic phase [36].

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Section: Reactions With Amines and Their Derivativesmentioning

confidence: 99%

“…Amidines 180, which have been recommended as anticoagulants and diuretics 147, 149 ± 151 and also possess hypoglycemic activity 152,153 or are used in the synthesis of hypoglycemic preparations, 147 are obtained by the reaction of the imidate 6a with alkylaromatic amines.…”

Section: Reactions With Amines and Their Derivativesmentioning

confidence: 99%

2,3,4,5-Tetrahydropyridine (Δ¹-piperideine) and its derivatives. Synthesis and chemical properties

Shvekhgeimer¹

1998

Russ. Chem. Rev.

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“…1 Later it was found that I also has hypoglycemic and diuretic properties in rats. 2 We therefore set out to find lactamimides that inhibit platelet aggregation without causing hypoglycemia or diuresis. Compound II (RMI 12.366A), which was reported earlier,2 meets these requirements.…”

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confidence: 99%

Substituted .alpha.-methylbenzyl and tricyclic arylalkyl lactamimides as inhibitors of blood platelet aggregation

Jm¹,

Gp²,

Rd³

1976

J. Med. Chem.

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N-[1-(p-Phenoxyphenyl)ethyl]hexahydro-2H-azepin-2-imine hydrochloride (10) and N-[1-(2-dibenzothienyl)-ethyl]hexahydro-2H-azepin-2-imine hydrochloride (22) were found to inhibit in vitro aggregation of human blood platelets induced by ADP with minimal release of procoagulant platelet factor 3. The compounds were selected from a series of substituted alpha-methylbenzyl and tricyclic arylalkyl lactamimides that were free of hypoglycemic and diuretic effects. Compounds 10 and 22, as well as N-[1-(1-naphthyl)ethyl]hexahydro-2H-azepin-2-imine hydrochloride (I) and N-(2,2-diphenylpentyl)hexahydro-2H-azepin-2-imine hydrochloride (II), were evaluated for effects on ADP-induced platelet aggregation after repeated oral administration to guinea pigs. Compound II (RMI 12,366A) showed in vivo activity in this system 2 h after the last of four daily doses of 100 mg/kg po.

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ChemInform Abstract: BENZHYDRYL AND FLUORENYL LACTAMIMIDES WITH HYPOGLYCEMIC, DIURETIC, BLOOD PLATELET AGGREGATION INHIBITORY, AND ANTIINFLAMMATORY ACTIVITIES

Grisar¹,

Claxton²,

Wiech³

et al. 1973

Chemischer Informationsdienst

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Benzhydryl and fluorenyl lactamimides with hypoglycemic, diuretic, blood platelet aggregation inhibitory, and antiinflammatory activities

Cited by 13 publications

References 0 publications

2,3,4,5-Tetrahydropyridine (Δ¹-piperideine) and its derivatives. Synthesis and chemical properties

2,3,4,5-Tetrahydropyridine (Δ¹-piperideine) and its derivatives. Synthesis and chemical properties

Substituted .alpha.-methylbenzyl and tricyclic arylalkyl lactamimides as inhibitors of blood platelet aggregation

ChemInform Abstract: BENZHYDRYL AND FLUORENYL LACTAMIMIDES WITH HYPOGLYCEMIC, DIURETIC, BLOOD PLATELET AGGREGATION INHIBITORY, AND ANTIINFLAMMATORY ACTIVITIES

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Benzhydryl and fluorenyl lactamimides with hypoglycemic, diuretic, blood platelet aggregation inhibitory, and antiinflammatory activities

Cited by 13 publications

References 0 publications

2,3,4,5-Tetrahydropyridine (Δ1-piperideine) and its derivatives. Synthesis and chemical properties

2,3,4,5-Tetrahydropyridine (Δ1-piperideine) and its derivatives. Synthesis and chemical properties

Substituted .alpha.-methylbenzyl and tricyclic arylalkyl lactamimides as inhibitors of blood platelet aggregation

ChemInform Abstract: BENZHYDRYL AND FLUORENYL LACTAMIMIDES WITH HYPOGLYCEMIC, DIURETIC, BLOOD PLATELET AGGREGATION INHIBITORY, AND ANTIINFLAMMATORY ACTIVITIES

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2,3,4,5-Tetrahydropyridine (Δ¹-piperideine) and its derivatives. Synthesis and chemical properties

2,3,4,5-Tetrahydropyridine (Δ¹-piperideine) and its derivatives. Synthesis and chemical properties