Benzene-methanol as a solvent in aromatic nucleophilic substitution

Dipolar Aprotic Solvents in Bimolecular Aromatic Nucleophilic Substitution Reactions1

“…constants at a standard ionic strength (0.0445 M) have been multiplied by3,4 and 10 in TableIfor reactions of Lil, KSCN and LiBr, respectively, in acetone. It is apparent…”

Isokinetic relationships for SNAr reactions in different solvents

“…From temperature‐dependent rate data, the Eyring plots were generated by plotting log( k / T ) versus 1/ T exp , and the enthalpy and entropy of activation, ∆ H ≠ and ∆S ≠ , were determined for the S N Ar reactions of compounds 9 , 10 , 10a , 10aa , 10b , 10bb , 10c , 10cc , 10d , 10dd , 10e , 10ee , 10f , 10ff , 10g , 10h , 10i , 10j , 10k , 10l , 10m , 10n , 10o , 10p , 10q , 10r , 10s , 10t , 10u , 10v , 10x , 10y , 10z , 11 , 12 , 12b , 12d , 12dd , 12e , 12ff , 12g , 12i , 12l , 12m , 12o , 12q , 12s , 12u , 12w , 13 , 14 , 15 , 15a , 15aa , 15b , 15bb , 15c , 15cc , 15d , 15dd , 15e , 15ee , 15f , 15ff , 15g , 15h , 15i , 15j , 15k , 15l , 15m , 15n , 15o , 15p , 15q , 15r , 15s , 15t , 15u , 15v , 15x , 15y , 15z , 16 , 16a , 16aa , 16b , 16bb , 16c , 16cc , 16d , 16dd , 16e , 16ee , 16f , 16ff , 16g , 16h , 16i , 16j , 16k , 16l , 16m , 16n , 16o , 16p , 16q , 16r , 16s , 16t , 16u , 16v , 16x , 16y , 16z , 17 , 17a , 17aa , 17b , 17bb , 17c , 17cc , 17d , 17dd , 17e , 17ee , 17f , 17ff , 17g , 17h , 17i , 17j , 17k , 17l , 17m , 17n , 17o , 17p , 17q , 17r , 17s , 17t , 17u , 17v , 17x , 17y , 17z , 18 , 18a , 18aa , 18b , 18bb , 18c , 18cc , 18d , 18dd , 18e , 18ee , 18f , 18ff , 18g , 18h , 18i , 18j , 18k , 18l , 18m , 18n , 18o , 18p , 18q , 18r , 18s , 18t , 18u , 18v , 18x , 18y , 18z , 19 , 19a , 19aa , 19b , 19bb , 19c , 19cc , 19d , 19dd , 19e , 19ee , 19f , 19ff , 19g , 19h , 19i , 19j , 19k , 19l , 19m , 19n , 19o , 19p , 19q , 19r , 19s , 19t , 19u , 19v , 19x , 19y , 19z , 20 , 20a , 20aa , 20b , 20bb , 20c , 20cc , 20d , 20dd , 20e , 20ee , 20f , 20ff , 20g , 20h , 20i , 20j , 20k , 20l , 20m , 20n , 20o , 20p , 20q , 20r , 20s , 20t , 20u , 20v , 20x , 20y , 20z , 21 , 21a , 21aa , 21b , 21bb , 21c , 21cc , 21d , 21dd , 21f , 21ff , 21g , 21h , 21i , 21j , 21k , 21l , 21m , 21n , 21o , 21p , 21q , 21r , 21s , 21t , 21u , 21v , 21w , 21x , 21y , 21z with charged and uncharged nucleophiles 1 , 1a , 1aa , 1b , 1bb , 1c , 1cc , 1d , 1dd , 1e , 1ee , 1f , 1ff , 1g , 1h , 1i , 1j , 1k , 1l , 1m , 1n , 1o , 1p , 1q , 1r , 1s , 1t , 1u , 1v , 1x , 1y , 1z , 2 , 2a , 2aa , 2b , 2bb , 2c , 2cc , 2d , 2dd , 2e , 2ee , 2f , 2ff , 2g , 2h , 2i , 2j , 2k , 2l , 2m , 2n , 2o , 2p , 2q , 2r , 2s , 2t , 2u , 2v , 2x , 2y , 2z , 3 , 3a , 3aa , 3b , 3bb , 3c , 3cc , 3d , 3dd , 3e , 3ee , 3f , 3ff , 3g , 3h , 3i , 3j , 3k , 3l , 3m , 3n , 3o , 3p , 3q , 3r , 3s , 3t , 3u , 3v , 3x , 3y , 3z , 4 , 6 , 8 (Scheme ) . The ∆ H ≠ , ∆S ≠ , and ∆G ≠ activation parameters obtained were used by Eqns – to establish the δ ∆ H ≠ , δ ∆ S ≠ , and δ ∆ G ≠ reaction constants .…”