Benzalkonium chloride inhibited the histamine release from rat peritoneal mast cells induced by bradykinin and glcnac oligomer-specific lectin datura stramonium agglutinin, but heparin did not

Niitsuma, Akinao; Uchida, Masaatsu K.; Suzuki-Nishimura, Tamiko

doi:10.1016/0306-3623(95)00082-8

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…This result investigated that these polysaccharides were removed almost completely by washing. This result agrees well with the study of Niitsuma et al [17]. However the inhibition ratio of S-HA was higher than that of other polysaccharides in a certain extent, and inhibition ratio (%) than 1.2S-HA.…”

Section: The Inhibitory Effect Of S-ha On Histamine Release Induced Bsupporting

confidence: 83%

“…However, Hep slightly suppressed the histamine release only at high concentration (100 µg/ml). This result agrees well with the study of Niitsuma et al [17], Ghosh et al [18] and Tones [19]. They reported that Hep, an anionic polysaccharide, electrostatically interacted with a cationic compound 48/80, and that as a result Hep inhibited the histamine release activity of compound 48/80.…”

Section: The Inhibitory Effect Of S-ha On Histamine Release Induced Bsupporting

confidence: 83%

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The Basic Research on Physiological Property of Functionalized Hyaluronan (II): Effect of Sulfated Hyaluronan on Histamine Release from the Mast Cell

et al. 2004

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Hyaluronan (HA) is one of polysaccharides in living body that is found widely in connective tissue of the mammals. It has no sulfate group but high molecular weight in comparison with other glycosaminoglycans (GAGs). We synthesized sulfated HA (S-HA) with various degrees of substitution (D.S.) in order to give HA new biological functions, since GAGs with sulfate groups interact with various biocomponents to express some specific biofunctions. Moreover in order to develop biomedical polymers, immunological response against artificial polymer matrices must be evaluated. So we measured histamine release from the mast cell and discussed the effect of S-HA on the immunological response. It was confirmed that they could be used as biomedical materials with immunological safety. And S-HA inhibited the histamine release that was induced by compound 48/80 from the mast cell. The inhibitory effect of S-HA was seemed to be due to such various factors as D.S., molecular weight, substitution site of the sulfate group and the structure of a polysaccharide chain.

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Section: The Inhibitory Effect Of S-ha On Histamine Release Induced Bsupporting

confidence: 83%

Section: The Inhibitory Effect Of S-ha On Histamine Release Induced Bsupporting

confidence: 83%

The Basic Research on Physiological Property of Functionalized Hyaluronan (II): Effect of Sulfated Hyaluronan on Histamine Release from the Mast Cell

et al. 2004

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Effect of cationic peptides on rat ileum muscle contraction and histamine release from rat peritoneal mast cells

et al. 2002

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Characterization of Redox Activity in Resting and Activated Mast Cells by Reduction and Reoxidation of Lipophilic Nitroxides

Suzuki-Nishimura

Swartz

1998

General Pharmacology: The Vascular System

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Benzalkonium chloride inhibited the histamine release from rat peritoneal mast cells induced by bradykinin and glcnac oligomer-specific lectin datura stramonium agglutinin, but heparin did not

Cited by 5 publications

References 15 publications

The Basic Research on Physiological Property of Functionalized Hyaluronan (II): Effect of Sulfated Hyaluronan on Histamine Release from the Mast Cell

The Basic Research on Physiological Property of Functionalized Hyaluronan (II): Effect of Sulfated Hyaluronan on Histamine Release from the Mast Cell

Effect of cationic peptides on rat ileum muscle contraction and histamine release from rat peritoneal mast cells

Characterization of Redox Activity in Resting and Activated Mast Cells by Reduction and Reoxidation of Lipophilic Nitroxides

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