Bentonite clay incorporated topical film formulation for delivery of trimetazidine: Control of ocular pressure and in vitro-in vivo correlation

Swain, Rakesh; Nandi, Souvik; Sahoo, Rudra Narayan; Swain, Shasank S.; Mohapatra, Sujata; Mallick, Subrata

doi:10.1016/j.jddst.2021.102956

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…It is also clear that more sustained VB release was attained in BC-reinforced TPS/VB. This behavior might be ascribed to the barrier properties of the clay, which hinders the fast penetration of hydrophilic VB into aqueous media by creating a tortious path, as described by the effect of clay on the release of VB and various drugs in the literature [59][60][61][62].…”

Section: Release Pro Le Of Vitamin B 2 From Nanocompositementioning

confidence: 99%

Thermoplastic starch/bentonite clay nanocomposite reinforced with vitamin B2: Physicochemical characteristics and release behavior

Heydari

KhajeHassani

Daneshafruz

et al. 2023

Preprint

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Thermoplastic starch (TPS) attracted great interest in the biopolymer industry due to its obvious advantages, such as biodegradability and renewable resources, as substitutes for petroleum-based materials. This study is focused on designing TPS/bentonite clay (BC) nanocomposite (TPS/BC) reinforced with vitamin B2 (VB). The TPS nanocomposites loaded with various contents of BC were prepared using regular cornstarch/clay plasticized with glycerol. Subsequently, the various content of VB was encapsulated into TPS/BC. The effects of VB were investigated on the physicochemical properties of the TPS/BC films including mechanical and thermal properties, water uptake, and weight loss in water. The tensile strength and Young’s modulus of TPS/BC/VB films were found to increase significantly with adding and rising the VB content. The highest tensile and Young’s modulus values were observed for the nanocomposites containing 5 php of VB and 3 php of BC which indicates their synergistic effects on the mechanical properties of TPS. TPS reinforced with 1 php and 5 php VB showed an increase in water uptake compared to the TPS. The release of VB was evaluated from the nanocomposite films. Our findings show that higher BC content leads to lower VB release, which indicates the control of VB release by BC content.

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Section: Release Pro Le Of Vitamin B 2 From Nanocompositementioning

confidence: 99%

Thermoplastic starch/bentonite clay nanocomposite reinforced with vitamin B2: Physicochemical characteristics and release behavior

Heydari

KhajeHassani

Daneshafruz

et al. 2023

Preprint

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“…eye drops and eye ointments have certain disadvantages such as poor availability, repeated administration and irregular doses and the drug loss due to nasolacrimal drainage. 9 Reducing the volume of dose could moderately develop some local action and diminish side effects. As a solid film formulation this could be one improvement step for ophthalmic delivery of drug.…”

Section: Introductionmentioning

confidence: 99%

Aspirin-hydrogel ocular film for topical delivery and ophthalmic anti-inflammation

Nanda

Das

Sahoo

et al. 2022

JSCS

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Ocular drug delivery in hydrogel forming film form has several benefits over conventional dosage forms. Ophthalmic anti-inflammation study have been undertaken using topically applied aspirin in hydrogel film formulation. Hydroxypropyl methylcellulose (HPMC) matrix film formulation was prepared by solvent casting and evaporation technique by taking triethanolamine (TEA) as a plasticizer. Ex vivo corneal permeation as well as anti-inflammatory potential of aspirin was studied on carrageenan induced rabbit eye model. Moisture uptake was found to be in the range of 17.097 and 19.139 % for all the film formulations. Higher HPMC content in the film exhibited increased both the moisture uptake and content of swelling. Among the formulations the swelling order was found to be increasing according to the increasing amount of HPMC in the film. Presence of hydrogel matrix forming polymer sustained the drug release and corneal permeation for more than 6 h and controlled the process by diffusion mechanism. The signs of carrageenan induced acute inflammation have been inhibited completely just within 2 h of placing the film in the rabbit eye whilst the positive control continued showing redness and increased tear secretion. Aspirin ocular film formulation could be utilized for ocular anti-inflammation for an extended period of time with better patient compliance.

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“…Clay minerals have been used in the biomaterials area as a support for the transport of biologically active molecules due to their excellent chemical, physical, and non-toxic characteristics [ 8 , 9 , 10 , 11 ]. A wide range of biologically active molecules has been used in systems with clay minerals as carriers, including doxorubicin [ 12 ], diclofenac [ 13 ], ketoprofen [ 14 ], and trimetazidine [ 15 ]. Amino acids have a broad spectrum of chemical reactivity, are involved in several biochemical processes, and present the possibility of modulating their interactions with solid surfaces, for example, pH, ionic strength, and others [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Clay Mineral Minerals as a Strategy for Biomolecule Incorporation: Amino Acids Approach

et al. 2021

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The potential use of amino acids by ruminal microorganisms converting them into microbial protein for ruminants makes it challenging to supplement these nutrients in an accessible form in animals’ diets. Several strategies to protect amino acids from ruminal degradation were reported, producing amino acids available for the protein used in the intestine called “bypass.” The intercalation of biomolecules in clay mineral minerals has gained notoriety due to its ability to support, protect, transport, physicochemical properties and non-toxicity. This study aimed to investigate the incorporation of L-lysine (Lys), L-methionine (Met), and L-tryptophan (Trp) amino acids in the clay minerals sepiolite (Sep) and Veegum® (Veg) using the adsorption method. The characterization techniques of X-ray diffraction and infrared spectroscopy indicated the presence of biomolecules in the inorganic matrices. Elemental and thermal analyzes monitored the percentages of incorporated amino acids. They showed better incorporation capacities for Veg, such as Met-Veg < Lys-Veg < Trp-Veg and Lys-Sep < Met-Sep < Trp-Sep for sepiolite, except for the incorporation of Met. Matrices provide a promising alternative for planning the administration of biomolecules, using essential amino acids as models, and may offer an alternative to improve functional diet strategies.

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Bentonite clay incorporated topical film formulation for delivery of trimetazidine: Control of ocular pressure and in vitro-in vivo correlation

Cited by 7 publications

References 32 publications

Thermoplastic starch/bentonite clay nanocomposite reinforced with vitamin B2: Physicochemical characteristics and release behavior

Thermoplastic starch/bentonite clay nanocomposite reinforced with vitamin B2: Physicochemical characteristics and release behavior

Aspirin-hydrogel ocular film for topical delivery and ophthalmic anti-inflammation

Clay Mineral Minerals as a Strategy for Biomolecule Incorporation: Amino Acids Approach

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