Benincasa hispida alleviates amyloid pathology by inhibition of Keap1/Nrf2-axis: Emphasis on oxidative and inflammatory stress involved in Alzheimer's disease model

Rapaka, Deepthi; Bitra, Veera Raghavulu; Ummidi, Ravishankar; Akula, Annapurna

doi:10.1016/j.npep.2021.102151

Cited by 18 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cogn [Cucurbitaceae] showed a reduction in inflammatory cytokines levels of TNF-α and IL-1β, along with elevated levels of antioxidant enzyme markers (Rapaka et al, 2021). These Chinese herbs have been extensively used to prevent and treat various disorders associated with inflammatory and oxidative stress responses in the respiratory system (Yang et al, 2007;Park et al, 2016;Hu et al, 2020;Rapaka et al, 2021). RVD was a common parameter when assessing lung function, with a prevalence in the population.…”

Section: Discussionmentioning

confidence: 99%

Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder

et al. 2022

View full text Add to dashboard Cite

Fine particulate matter (PM2.5) is well known to impair lung function. Strategies protecting against PM2.5-exerted lung dysfunction have been less investigated. Qianjinweijing decoction (QJWJ), a decoction of a herbal medicine of natural origin, has been used to treat lung disorders as it inhibits oxidation and inflammation. However, no clinical trial has yet evaluated the role of QJWJ in PM2.5-induced lung dysfunction. Therefore, we conducted a randomized, double-blind, placebo-controlled trial to assess whether QJWJ provided lung benefits against the adverse effects of PM2.5 exposure among adults. Eligible participants (n = 65) were recruited and randomized to receive QJWJ decoction (n = 32) or placebo (n = 33) for 4 weeks. The restrictive ventilatory defect (RVD), lung function parameters, and induced sputum were analyzed. The PM2.5 exposure concentration was significantly associated with the vital capacity (VC), peak expiratory flow (PEF), and forced expiratory flow at 75% of the forced vital capacity (FEF75). The negative associations between PM2.5 and the lung function parameters were eliminated in response to the QJWJ intervention. Additionally, the percentage of RVD (P = 0.018) and the proportion of eosinophils (Eo%) in induced sputum (P = 0.014) in the QJWJ group was significantly lower than that in the placebo group. This study demonstrated that QJWJ could alleviated PM2.5-induced lung dysfunction and could be a potential treatment for air pollution-related chronic respiratory disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It induces oxidative stress, alters the blood-brain barrier, leading to the apoptotic death of hippocampal neurons. It also promotes the expression of the amyloid [41] , tau [38] proteins and alters the acetylcholine and other monoamine levels [40] . In previous studies, it has also been shown to alter the behavioural aspects of rodents.…”

Section: Methods Detailsmentioning

confidence: 99%

“…In previous studies, it has also been shown to alter the behavioural aspects of rodents. Finally, leading to the expression of all the pathological hallmarks of Alzheimer's disease [37] , [38] , [39] , [40] , [41] , [42] .…”

Section: Methods Detailsmentioning

confidence: 99%

“… Amyloid plaques, Tangles, neurotransmitter alterations, cognitive deficits, oxidative stress, gliosis, neuroinflammation. Al (5mg/kg, 10mg/kg, i.p, 60days) Al (4.2mg/kg, i.p, 28 days) Al (100mg/kg, oral) [37] , [38] , [39] , [40] , [41] , [42] 11. Methionine Male Wistar albino rats aged 3 months Cholinergic deficits, endothelial dysfunction, neuroinflammation, gliosis, cognitive deficits, oxidative stress 1.7g/kg per day p.o for 32 days 1.7 g/kg per day p.o.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease

2022

Self Cite

View full text Add to dashboard Cite

“…1,2 It is also known as senile dementia because it mainly affects the geriatric population. 3 AD is ranked as the 5th major cause of mortality in aged people and the 6th among all ages. 2 Worldwide, about 50 million people were affected by AD in 2018, and the number is expected to surpass 150 million by 2050.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride‐induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO‐1/NF‐κB signaling

Alsharif

Albrakati

omairi

et al. 2022

Environmental Toxicology

View full text Add to dashboard Cite

Prodigiosin (PDG) is a bacterial metabolite with numerous biological and pharmaceutical properties. Exposure to aluminium is considered a root etiological factor in the pathological progress of Alzheimer's disease (AD). Here, in this investigation, we explored the neuroprotective potential of PDG against aluminium chloride (AlCl 3 )mediated AD-like neurological alterations in rats. For this purpose, rats were gavaged either AlCl 3 (100 mg/kg), PDG (300 mg/kg), or both for 42 days. As a result of the analyzes performed on the hippocampal tissue, it was observed that AlCl 3 induced biochemical, molecular, and histopathological changes like those related to AD. PDG pre-treatment significantly decreased acetylcholinesterase activity and restored the levels of brain-derived neurotrophic factor, monoamines (dopamine, norepinephrine, and serotonin), and transmembrane protein (Na + /K + -ATPase). Furthermore, PDG boosted the hippocampal antioxidant capacity, as shown by the increased superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione

show abstract

Benincasa hispida alleviates amyloid pathology by inhibition of Keap1/Nrf2-axis: Emphasis on oxidative and inflammatory stress involved in Alzheimer's disease model

Cited by 18 publications

References 33 publications

Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder

Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder

Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease

Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride‐induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO‐1/NF‐κB signaling

Contact Info

Product

Resources

About