Benign Tumors of the Spine

Thakur, Nikhil; Daniels, Alan H.; Schiller, Jonathan R.; Valdes, Mauricio; Czerwein, John; Schiller, Alan L.; Esmende, Sean; Terek, Richard M.

doi:10.5435/jaaos-20-11-715

Cited by 34 publications

(28 citation statements)

References 44 publications

(60 reference statements)

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“…Given the high sensibility and specificity of MRI for fat and vascular tissues, these lesions were detected mostly as “incidentaloma,” the vertebral hemangioma being a dysembryogenetic (hamartomatous) mass, composed of thin-walled vessels lined by flat, bland endothelial cells infiltrating the medullary cavity between bone trabecule (120–123). …”

Section: Clinical Conditions Of Altered Bone/vasculature Complexmentioning

confidence: 99%

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Bone Vascularization in Normal and Disease Conditions

Carulli¹,

Innocenti²,

Brandi³

2013

Front. Endocrinol.

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Bone vasculature is essential for many processes, such as skeletal development and growth, bone modeling and remodeling, and healing processes. Endothelium is an integral part of bone tissue, expressing a physiological paracrine function via growth factors and chemokines release, and interacting with several cellular lines. Alterations of the complex biochemical interactions between vasculature and bone cells may lead to various clinical manifestations. Two different types of pathologies result: a defect or an excess of bone vasculature or endothelium metabolism. Starting from the molecular basis of the interactions between endothelial and bone cells, the Authors present an overview of the recent acquisitions in the physiopathology of the most important clinical patterns, and the modern therapeutic strategies for their treatments.

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Section: Clinical Conditions Of Altered Bone/vasculature Complexmentioning

confidence: 99%

“…Standard medical management is addressed in order to solve the symptoms. Rarely, a significant compression on nerve roots may need surgery, generally with conventional procedures (vertebroplasty, kyphoplasty) (145). …”

Section: State Of the Art Of The Therapeutic Approaches And The Futumentioning

confidence: 99%

Bone Vascularization in Normal and Disease Conditions

Carulli¹,

Innocenti²,

Brandi³

2013

Front. Endocrinol.

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“…While cerebral aneurysms and brain tumors require acute care followed by an extending hospital stay, primary spinal neoplasms may develop for months before exhibiting symptoms that require hospitalization. [37]. …”

Section: Discussionmentioning

confidence: 99%

Disparities in reportable quality metrics by insurance status in the primary spine neoplasm population

et al. 2017

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STUDY DESIGN Retrospective cohort study. BACKGROUND CONTEXT CMS defines “adverse quality events” as the incidence of certain complications such as post-surgical hematoma and/or iatrogenic pneumothorax during an inpatient stay. Patient safety indicators (PSI) are a means to measure the incidence of these adverse events. When these occur, reimbursement to the hospital decreases. The incidence of adverse quality events among patients hospitalized for primary spinal neoplasms is unknown. Similarly, it is unclear what the impact of insurance status is on adverse care quality among this patient population. PURPOSE We aimed to determine the incidence of patient safety indicators (PSI) among patients admitted with primary spinal neoplasms, and to determine the association between insurance status and the incidence of PSI in this population. STUDY DESIGN Retrospective cohort design PATIENT SAMPLE All patients, 18 years and older, in the Nationwide Inpatient Sample (NIS) that were hospitalized for primary spine neoplasms from 1998–2011. OUTCOME MEASURES Incidence of PSI from 1998–2011. METHODS The Nationwide Inpatient Sample (NIS) was queried for all hospitalizations with a diagnosis of primary spinal neoplasm during the inpatient episode from 1998–2011. Incidence of PSI was determined using publicly available lists of ICD-9-CM diagnosis codes. Logistic regression models were used to determine the effect of primary payer status on PSI incidence. All comparisons were made between privately insured patients and Medicaid/self-pay patients. RESULTS We identified 6,095 hospitalizations in which a primary spinal neoplasm was recorded during the inpatient episode. We excluded patients younger than 18 years as well as those with “other” or “missing” primary insurance status, leaving 5,880 patients for analysis. After adjusting for patient demographics and hospital characteristics, Medicaid/self-pay patients had significantly greater odds of experiencing one or more PSI (OR 1.81 95% CI 1.11– 2.95) relative to privately insured patients. CONCLUSIONS Among patients hospitalized for primary spinal neoplasms, primary payer status predicts the incidence of PSI, an indicator of adverse healthcare quality used to determine hospital reimbursement by CMS. As reimbursement continues to be intertwined with reportable quality metrics, identifying vulnerable populations is critical to improving patient care.

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“…The differential diagnosis for this lesion may be challenging, particularly with regard to the possibility of the presence of osteoid osteoma, osteoblastoma, ABC, osteochondroma, neurofibroma, eosinophilic granuloma, hemangioma and other giant-cell-containing tumors of bone, including GCT, GCRG, brown tumor of hyperparathyroidism and telangiectatic osteosarcoma. The evaluation of spinal tumors includes a thorough history assessment, physical examination, imaging and, occasionally, laboratory evaluation and biopsy when indicated (1). …”

Section: Discussionmentioning

confidence: 99%

“…A spinal location for an ABC is extremely rare. Fibrohistiocytoma is a type of primary benign bone tumor, which is composed of fusiform fibroblasts (1,2). It is a rare bone tumor, whose predilection site is the pelvis.…”

Section: Introductionmentioning

confidence: 99%

Fibrohistiocytoma combined with an aneurysmal bone cyst at T7 in a 63-year-old woman

Dong

et al. 2013

Experimental and Therapeutic Medicine

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We present a case of spinal tumor, with fibrohistiocytoma combined with aneurysmal bone cyst (ABC) at the pedicle and transverse process of T7 in a 63-year-old female. ABC is a rare skeletal tumor and spinal ABC is extremely rare. Fibrohistiocytoma is a type of primary benign bone tumor. ABC is also a rare bone tumor that most often occurs in the pelvis. The combined lesion of two primary bone benign tumors is relatively rare in clinic. In addition, fibrohistiocytoma and ABC are widely confused with other giant cell containing tumors of the bone. X-rays, magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) scans were performed and assessed. Finally, the diagnosis was confirmed by pathological tests. The patient underwent surgery and had an extremely good recovery. The correct diagnosis of a spine tumor is important when determining the surgical procedure.

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Benign Tumors of the Spine

Cited by 34 publications

References 44 publications

Bone Vascularization in Normal and Disease Conditions

Bone Vascularization in Normal and Disease Conditions

Disparities in reportable quality metrics by insurance status in the primary spine neoplasm population

Fibrohistiocytoma combined with an aneurysmal bone cyst at T7 in a 63-year-old woman

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