Benign Spindle Cell Tumors of the Mammary Stroma: Diagnostic Criteria, Classification, and Histogenesis

Magro, Gaetano; Michal, Michal; Bisceglia, Michele

doi:10.1078/0344-0338-00112

Cited by 81 publications

(100 citation statements)

References 77 publications

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“…The previously reported immunohistochemical profile of spindle cell lipoma has generally included positive staining for CD34 and vimentin and negative staining for S100 (Lombardi et al 1994;Magro et al 2001). In the present study, tumour cells exhibited immunoreactivity to CD34 and vimentin but not to S100.…”

Section: Discussionsupporting

confidence: 58%

Spindle cell lipoma in the gingiva of a dog: a case report

Kim¹,

Choi²,

Lee³

et al. 2015

Vet. Med. - Czech

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Spindle cell lipoma is a benign lipomatous tumour that mainly occurs in the subcutis of the head, neck, and shoulder in elderly men. Oral spindle cell lipoma is extremely rare in all species, and no cases have been reported in veterinary medicine. A 10-year-old male Maltese dog was presented for evaluation of a whiteto cream-coloured gingival mass. Microscopically, the mass was composed of mature fat cells and spindle cells containing thick fibrocollagenous bundles. The neoplastic cells showed positive immunoreactivity to vimentin and CD34. Based on the clinical and histopathological findings, spindle cell lipoma of the gingiva was diagnosed. Further immunohistochemical analysis revealed that both adipocytes and spindle cells exhibited positive reactions to oestrogen receptors α and β. These findings demonstrate the clinical, morphological, and immunohistochemical characteristics of an oral spindle cell tumour. The potential role of sex steroid hormones in the pathogenesis of this tumour is also discussed.

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Section: Discussionsupporting

confidence: 58%

Spindle cell lipoma in the gingiva of a dog: a case report

Kim¹,

Choi²,

Lee³

et al. 2015

Vet. Med. - Czech

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“…Numerous reports showed that even though extramammary fibromatosis usually exhibit positivity for ER and PR, mammary fibromatosis is consistently devoid of such receptors. 2,8,12 moreover, Devouassoux-Shisheboran et al have shown that cytoplasmic pS2 protein expression, which is induced by estrogen, is consistently negative in their series of 33 cases.…”

Section: Fig 1: Showing Sonomammogrm Of Right Breast Fig 2: Sectionmentioning

confidence: 99%

Aggressive Fibromatosis of Breast: A Rare Case Report

Sharma¹,

Daral²,

Singla³

et al. 2014

jemds

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Fibromatosis, a locally aggressive but non-metastasizing neoplastic proliferation of fibroblastic cells, commonly encountered in the abdominal wall and extra-abdominal sites but rarely occurs in the breast. Here we report a case of aggressive fibromatosis of breast, which presented as a palpable mass in the right breast of a 53-year-old female. The physical examination revealed a 12x10 cm sized ovoid mass in the right upper outer quadrant. Ultrasonogram demonstrated an 8x5 cm sized hypoechoic mass with peripheral increased vascularity on doppler imaging. Wide local excision was done and pathology revealed aggressive fibromatosis.

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“…CD34 positivity on fibroblasts is thought to represent an uncommitted cell capable of multidirectional mesenchymal differentiation. 26 Prior studies have also suggested that there is an inverse relationship between myofibroblastic differentiation and CD34 positivity. 27 The presence of CD34 on 75.6% of live harvested uncultured versus 7.84% of cultured fibroblasts suggests that fibroblasts in a nonactivated resting state within the skin dermis have not undergone myofibroblastic differentiation characteristic of the activated phenotype.…”

Section: Discussionmentioning

confidence: 99%

Live Fibroblast Harvest Reveals Surface Marker Shift In Vitro

Walmsley

Rinkevich

et al. 2015

Tissue Engineering Part C: Methods

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Current methods for the isolation of fibroblasts require extended ex vivo manipulation in cell culture. As a consequence, prior studies investigating fibroblast biology may fail to adequately represent cellular phenotypes in vivo. To overcome this problem, we describe a detailed protocol for the isolation of fibroblasts from the dorsal dermis of adult mice that bypasses the need for cell culture, thereby preserving the physiological, transcriptional, and proteomic profiles of each cell. Using the described protocol we characterized the transcriptional programs and the surface expression of 176 CD markers in cultured versus uncultured fibroblasts. The differential expression patterns we observed highlight the importance of a live harvest for investigations of fibroblast biology.

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Benign Spindle Cell Tumors of the Mammary Stroma: Diagnostic Criteria, Classification, and Histogenesis

Cited by 81 publications

References 77 publications

Spindle cell lipoma in the gingiva of a dog: a case report

Spindle cell lipoma in the gingiva of a dog: a case report

Aggressive Fibromatosis of Breast: A Rare Case Report

Live Fibroblast Harvest Reveals Surface Marker Shift In Vitro

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