Benign Solid and Acinar Mesothelioma (Adenomatoid Tumor)

Delahunt, Brett; Kenwright, Diane

doi:10.1097/01.pcr.0000168825.05587.5c

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…30 Rarely, an intratesticular adenomatoid tumor may occur, 31,32 as was nicely illustrated by Delahunt and Kenwright (see their Fig. 3), 32 and this may complicate this differential. Further, the cords of adenomatoid tumor, when of solid type, may mimic those of SSCT; however, SSCT usually contains entrapped seminiferous tubules, unlike intratesticular adenomatoid tumor.…”

Section: Discussionmentioning

confidence: 94%

“…Further, the cords of adenomatoid tumor, when of solid type, may mimic those of SSCT; however, SSCT usually contains entrapped seminiferous tubules, unlike intratesticular adenomatoid tumor. 31,32 In addition, the lesional cells in solid-type adenomatoid tumor are typically closely packed with little intervening stroma. The trabecular growth pattern of SSCT may be similar to that seen in carcinoid tumors, but the lack of "salt and pepper" nuclei with granular cytoplasm, and absence of acinar arrangements, should point to SSCT rather than carcinoid tumor.…”

Section: Discussionmentioning

confidence: 99%

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Sclerosing Sertoli Cell Tumor of the Testis

Kao¹,

Kum²,

Idrees³

et al. 2014

American Journal of Surgical Pathology

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Sclerosing Sertoli cell tumor (SSCT) of the testis is rare, with only 22 previously reported cases. Most have been small, circumscribed masses, and none has had a malignant clinical course; however, follow-up is limited. We have examined 20 new SSCTs to better characterize their features and report long-term follow-up. At least focal tubule formation by sex cord cells in a dense, hypocellular fibrous stroma occupying at least 50% of the lesion was required. The patient age ranged from 23 to 52 years (mean, 37; median, 39). All SSCTs were unilateral with 11 left sided and 9 right sided. The average size was 1.7 cm (range, 0.5 to 6 cm). In most cases, the stroma represented 50% to 70% of the mass but was at least 80% in 2. The Sertoli cells formed cords, trabeculae, small nests, focal tubules (sometimes with a vague pseudovascular or retiform appearance), and rarely single cells. Most tumor cells had small, round, oval to polygonal nuclei with finely granular chromatin, small nucleoli, and modest amounts of pale, eosinophilic cytoplasm. No mitotic figures, significant atypia, or necrosis was seen. All tumors but 1 were circumscribed and lacked lymphovascular invasion. Follow-up in 15 patients (3 mo to 16 y; mean, 6.1 y) showed 9 alive and free of disease, 5 alive with unknown disease status, and 1 patient, who presented with bone metastases, dead of disease at 27 months. The only features in the malignant case that differed from all others in our study were lymphovascular invasion and lack of circumscription. Combining our cases with previously reported ones shows that SSCTs are unilateral, usually small (80% <2 cm) tumors that occur in a wide age range (18 to 80 y old; mean, 35 y) and lack necrosis. Only 1 of 31 with follow-up (mean, 4.4 y) metastasized; this tumor was 3.8 cm and had lymphovascular invasion and invasive growth. We conclude that SSCTs<2 cm with the typical features and lacking those associated with malignancy in Sertoli cell tumors, not otherwise specified, have a negligible risk of metastasis and are adequately managed by orchiectomy alone.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Sclerosing Sertoli Cell Tumor of the Testis

Kao¹,

Kum²,

Idrees³

et al. 2014

American Journal of Surgical Pathology

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Adenomatoid Tumor of the Testis With Intratesticular Growth

Alexiev

Heath

et al. 2011

Int J Surg Pathol

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Adenomatoid tumor of the male genitourinary tract is a rare benign neoplasm thought to be of mesothelial origin. In exceptional cases, these lesions may involve the testicular parenchyma, of which there are only 9 published cases in the literature. The authors describe a rare case of a testicular tumor in a 41-year-old male with normal tumor markers. Histopathology and immunohistochemical studies revealed an adenomatoid tumor with intratesticular growth. No involvement of the epididymis or testicular membranes was identified. The morphological clues leading to the correct diagnosis of adenomatoid tumor and the possible histogenesis and differential diagnosis are discussed.

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Testicular Tumors—Some New and a Few Perennial Problems

Young

2008

Archives of Pathology &Amp; Laboratory Medicine

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The histopathology of testicular tumors is presented, emphasizing new, unusual, or underemphasized aspects. Within the category of seminoma of the usual type, the recent literature has drawn attention to the presence in occasional tumors of solid or hollow tubules or spaces of varying sizes and shape that may result in cribriform or microcystic patterns, causing potential confusion with other neoplasms, most notably Sertoli cell tumor or yolk sac tumor. Although regions of typical neoplasia and awareness of this phenomenon usually will be diagnostic, immunohistochemistry may play a role in excluding Sertoli cell tumor or yolk sac tumor. Although immunohistochemistry can play an undoubted helpful role in this and selected other areas of testicular tumor evaluation, careful evaluation of the gross and routine microscopic features will solve the vast majority of diagnostic problems. An excellent review of immunohistochemistry in this area by R. E. Emerson, MD, and T. M. Ulbright, MD, is cited herein. Spermatocytic seminoma remains a crucial pitfall in diagnosis, and the pathologist must always be alert to the possible diagnosis when looking at a seminomatous neoplasm, particularly in an older patient, although about one third of these tumors occur in the usual seminoma age range. The embryonal carcinoma has a great diversity of patterns, which are briefly noted. The enigmatic and picturesque tumor, polyembryoma, which virtually never occurs in pure form but may be a confusing component of a variety of mixed germ cell tumors, is discussed and illustrated. The phenomenon of burnt-out germ cell neoplasia is also briefly noted and an excellent recent contribution is referred to. Within the sex cord–stromal family of neoplasms, recent contributions and elaborations of unusual morphologic features of Leydig cell tumors and Sertoli cell tumors are presented. Within the Leydig cell family, cyst formation, adipose metaplasia, calcification or ossification, and spindle cell patterns may be particularly confusing, and in the Sertoli cell family, a great array of patterns caused by differing admixtures of tubular, solid, and stromal components occur. The peculiar lesion, intratubular large cell hyalinizing Sertoli cell tumor, of young boys with Peutz-Jeghers syndrome, is briefly discussed. Some of the problems in the family of hematopoietic neoplasms are reviewed, these processes posing diverse problems in differential diagnosis and their correct recognition having crucial therapeutic implications. Although secondary tumors to the testis have not received the same attention in the literature as the similar phenomenon in the female gonad, remarkable examples of testicular spread of diverse neoplasms, usually carcinoma but rarely melanoma, are seen, and the pathologist should be alert to this possibility, particularly when examining an unusual morphology in an older patient. Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction.

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Benign Solid and Acinar Mesothelioma (Adenomatoid Tumor)

Cited by 3 publications

References 24 publications

Sclerosing Sertoli Cell Tumor of the Testis

Sclerosing Sertoli Cell Tumor of the Testis

Adenomatoid Tumor of the Testis With Intratesticular Growth

Testicular Tumors—Some New and a Few Perennial Problems

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