Infiltrating intermuscular angiolipomas are rare. We report a cadaveric case of infiltrating angiolipoma in the muscles of the posterior axioappendicular region with literature in the context of live individuals. The macroscopic assessment showed a non-capsulated homogenous yellow mass was located between the trapezius muscle above and rhomboid major muscle below and invaded the dorsal scapular blood vessels from the rhomboid major muscle. It weighed 47.03 g, 8.5 cm x 6.6 cm x 1.7 cm (length, width, and thickness). Microscopic analysis shows mature fat cells, prominent blood vascular components, and no myxoid areas. Infiltrating intermuscular angiolipomas of the chest wall are very rare and to our knowledge, there is the scantiness of similar cases, hence we are providing an extra case of a giant infiltrating intermuscular angiolipoma of the posterior axioappendicular region, with particular emphasis on gross and microscopic features. In such cases, angiolipomas would require complete surgical excision to prevent continued growth, invasion, and recurrence.