Benign sclerosing pneumocytoma of lung (sclerosing haemangioma)

Abstract

The clinical and histopathological features of 14 cases of so-called sclerosing haemangioma of the lung are described. All developed in Hong Kong Chinese women. Histochemical and ultrastructural study of these tumours indicates an epithelial origin. The term benign sclerosing pneumocytoma is suggested as being more appropriate for this unusual tumour.Liebow and Hubbell in 1956 described seven examples of a rare, benign pulmonary tumour under the term sclerosing haemangioma.' Patients presented with haemoptysis or with a coin lesion. The tumour showed a striking preponderance in women and was characterised microscopically by "vascular channels," sclerosis, papillae, sheets of cells, and haemorrhage in varying proportions. Considerable diagnostic confusion has occurred, however, since some of the reports have included plasma cell granuloma and histiocytic lesions inappropriately under the term sclerosing haemangioma and the reverse has also occurred.2-9 We review the clinicopathological features of 14 "sclerosing haemangiomas" that comply fully with the criteria of Liebow and Hubbell. This is the second largest series to be reported.'-'8 We also report the electronmicroscopic and histochemical findings for several of these tumours. On the basis of these findings we proffer the term benign sclerosing pneumocytoma as being more appropriate for this unusual tumour. MethodsThe 14 cases of "sclerosing haemangioma" studied were taken from the file of the Institute of Pathology, Hong Kong, from 1974 to 1980. Ten of these cases came from the Cardiothoracic Unit, Kowloon Hospital, including four that presented in 1980. The five most recent cases were also examined by electron microscopy from formalin-fixed material.All specimens were fixed in 10% buffered forma-

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“…"Pneumocytoma" has Histological examination showed features therefore been suggested as a more of chronic cholecystitis with fibrosis of the appropriate term. 6 gallbladder wall and a moderately severe In conclusion, there is strong evidence that chronic inflammatory infiltrate. There were the pulmonary alveolar adenoma represents also carcinoma cells infiltrating singly and in a histological variant of sclerosing haeman-files, mostly in the fibrous tissue deep to the gioma in which spaces lined by pneumocytes muscularis but in places extending up to the are either the predominant or exclusive mucosa (figure).…”

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“…pulmonary sclerosing hemangioma | whole-exome sequencing | AKT1 mutation | copy number alteration P ulmonary sclerosing hemangioma (PSH) is a benign tumor that usually presents as a solitary, well-defined mass in the lung (1). PSH predominantly affects females (1:5) with a higher incidence in the Far East (2).…”

Sclerosing Haemangioma of Lung Presenting as Spontaneous Haemothorax

“…Some patients had presented with vague chest pain and haemoptysis. Keengwa et al [3] in 1982 described 14 cases from Hong Kong, all in females and 7 were asymptomatic, detected as a coin lesion accidentally and others had cough or minimal chest pain and haemoptysis. Most were located near pleura.…”

“…Initially an endothelial origin for the tumour was proposed (Liebow et al), but electron microscopic studies have now demonstrated surfactant apoprotein, now believed to be arising from the Type II pneumocyte [4][5][6]. Some of them have named them as pneumocytomas [3]. In the past, sclerosing Tewari, et al haemangioma has been confused with plasma cell granuloma (histiocytoma), which is also called fibroxanthoma because of the fibrosclerotic tissue , cholesterol spaces and fat filled macrophages [7].…”