Benign prognosis in idiopathic hyper-CK-emia

Reijneveld, Jaap C.; Notermans, Nicolette C.; Linssen, W.H.J.P.; Wokke, John H. J.

doi:10.1002/(sici)1097-4598(200004)23:4<575::aid-mus17>3.0.co;2-5

Cited by 49 publications

(42 citation statements)

References 21 publications

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“…Perhaps also in our study the number of specific diagnoses may have increased because all cases had the full battery of testing. Recently, other authors have reported a long-term follow up in 23 hyperCKemic individuals, concluding that follow up did not help to make a diagnosis in them [33].…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels

Prelle¹,

Tancredi²,

Sciacco³

et al. 2002

Journal of Neurology

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Section: Discussionmentioning

confidence: 99%

Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels

Prelle¹,

Tancredi²,

Sciacco³

et al. 2002

Journal of Neurology

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“…Patients with persistently raised serum creatine kinase (sCK) activity in whom neuromuscular diseases have been excluded are labeled as having idiopathic hyperCKemia,and are usually reassured and discharged [4,10,20,21]. However, these patients may be at risk for systemic arterial hypertension.…”

Section: Introductionmentioning

confidence: 99%

Hypertension risk in idiopathic hyperCKemia

et al. 2008

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Patients with idiopathic hyperCKemia are usually reassured and discharged. However, these subjects may have increased hypertension risk, based on data from our population study, which showed that the population tertile with the highest serum creatine kinase activities had the highest systolic and diastolic blood pressure levels. Therefore, we assessed whether subjects with idiopathic hyperCKemia have greater occurrence of hypertension than controls. We included 46 participants aged 18 to 67 years, diagnosed with idiopathic hyperCKemia at the departments of Neurology of the Universities of Amsterdam and Utrecht, The Netherlands. We found that 48% of the subjects with idiopathic hyperCKemia were hypertensive, as compared to 19% of the random population controls (n = 22,612, aged 20 to 65 years), an odds ratio of 3.9 (95 % CI, 2.2 to 6.9) before, and 2.0 (1.1 to 3.8) after adjustment for sex, age, and body mass index. In accord with our previous finding of an association between creatine kinase and blood pressure in the general population, the data reported here suggest that subjects with idiopathic hyperCKemia have greater hypertension risk than controls. This may be due to relatively high tissue creatine kinase activity, resulting in greater ATP buffer capacity to create and sustain high blood pressure levels.Larger, prospective studies are needed to further assess this association, but as active case finding is important in the diagnosis of hypertension, subjects with idiopathic hyperCKemia should be screened and monitored for the presence of hypertension.

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“…The authors concluded that follow-up is not worthwhile or necessary (17). Six years ago we performed a retrospective study of 114 subjects with asymptomatic / oligosymptomatic hyperckemia.…”

Section: Introductionmentioning

confidence: 99%

Follow-up of a large population of asymptomatic/oligosymptomatic hyperckemic subjects

et al. 2006

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Six years before the present study we performed a retrospective study of 114 subjects presenting with asymptomatic / oligosymptomatic hyperckemia (raised creatine kinase blood levels), a diagnosis being made in 21 of them. We now present the results of a long-term follow-up in 55 of the still undiagnosed 93 individuals. Most of them have remained asymptomatic and did not develop specific neuromuscular disorders. One subject became frankly symptomatic manifesting limb-girdle weakness. A diagnosis of dystrophinopathy carrier and one of possible type I SMA carrier were indirectly made in another two subjects. Almost all subjects still have hyperckemia, though the mean creatine kinase (CK) value is lower than before. CK levels have become normal in 12 subjects. Two died of neoplasia, and six developed non-neuromuscular disorders. We noted no follow-up differences in terms of CK modifications between subjects with pathological EMG and/or muscle biopsy findings and those with normal findings at first examination.

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Benign prognosis in idiopathic hyper-CK-emia

Cited by 49 publications

References 21 publications

Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels

Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels

Hypertension risk in idiopathic hyperCKemia

Follow-up of a large population of asymptomatic/oligosymptomatic hyperckemic subjects

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