Benign primary hematuria

Pardo, Victoriano; Berian, M.Gregg; Levi, Donald F.; Strauss, José

doi:10.1016/0002-9343(79)90741-1

Cited by 60 publications

(8 citation statements)

References 15 publications

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“…The other type manifests hematuria, shows female predominance, a high tendency to spontaneous clinical remission and overall favorable clinical course. These hématurie patients possibly represent the same group as part of the patients in the previous materials of van de Putte et al [ 19] and Pardo et al [20], who studied hematuria patients.…”

Section: Discussionmentioning

confidence: 91%

Clinical Follow-Up of 54 Patients with IgM-Nephropathy

Saha

Mustonen²,

Pasternack³

et al. 1989

Am J Nephrol

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The clinical course of mesangial glomerulopathy with IgM deposits (IgM-nephropathy) was studied in 54 patients. The initial manifestations of the disease were nephrotic syndrome in 18, proteinuria in 21, proteinuria together with hematuria in 4 and isolated hematuria in 11 patients. The nephrotic syndrome was steroid-responsive in 60% of cases and of these 80% were steroid-dependent. During a 5-year postbiopsy follow-up 3 patients went into terminal uremia and in 6 more patients a milder renal insufficiency was observed. Three patients were rebiopsied and in 2 of these the second biopsy specimen disclosed typical focal and segmental glomerulosclerosis. Hematuria was a favorable sign, as no patient with hematuria showed progressive impairment of renal function. The prevalence of hypertension in the whole material was 37%. At close of follow-up 35% of all patients were in clinical remission. It is suggested that IgM-nephropathy associated with abundant proteinuria or the nephrotic syndrome represents a distinct disorder from that associated with hematuria. While the nephrotic type often manifested itself with a morphologic change and a tendency to develop renal insufficiency, the hematuric type showed female predominance, a high tendency to spontaneous clinical remission and a favorable clinical course.

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Section: Discussionmentioning

confidence: 91%

Clinical Follow-Up of 54 Patients with IgM-Nephropathy

Saha

Mustonen²,

Pasternack³

et al. 1989

Am J Nephrol

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“…That these studies included few patients with hematuria is most probably due to selection. The studies of van dc Putte et al [6] and Pardo et al [7] suggest, however, that hematuria is, in fact, an important clinical manifestation of IgM-associated glomerulonephritis. These authors reported frequent glomerular staining of IgM in patients with hematuria.…”

Section: Discussionmentioning

confidence: 99%

“…The studies cited have included only biopsy speci mens with proliferative lesions, and the study of Cohen et al [2] included only patients with proteinuria or the nephrotic syndrome. The idopathic nephrotic syndrome with so-called minimal-change glomerular morphology may also be associated with IgM fluorescence [4,5], and renal biopsies from patients with recurrent or persistent hematuria often show IgM on immunofluorescence exam ination [6,7],…”

Section: Introductionmentioning

confidence: 99%

IgM-Associated Glomerulonephritis

Helin¹,

Mustonen²,

Pasternack³

et al. 1982

Nephron

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In a series of 374 renal biopsy specimens, 26 from patients with primary glomerulonephritis showed IgM as the main glomerular immunofluorescence finding. By light microscopy 17 of these specimens showed mild mesangial hypercellularity and 9 were normal. Small mesangial electron-dense deposits were seen in 8 specimens. Of the 26 patients, 10 had proteinuria, 6 had the nephrotic syndrome, 6 had hematuria and 4 had both proteinuria and hematuria. The mean serum IgM level was significantly higher in the patients than in healthy controls. Circulating immune complexes were detected by three methods in 39% of the patients.

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“…Patients with gross or microscopic hematuria with mesangial IgM deposits show no decline in function, but continue to have hematuria on short-term evaluation. Helm et al [9], who have a significant number of patients presenting with hema turia alone, feel that hematuria is an important clinical manifestation of IgM-associated glomerulonephritis, since similar findings have been observed in two other studies of hematuria [2,18]. No longitudinal studies are available to determine whether patients with hematuria and IgM de posits behave differently from those who do not have such deposits.…”

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confidence: 86%