Benign Müllerian inclusions coexisting with breast metastatic carcinoma in an axillary lymph node

Epithelioid Cells in Mediastinal Lymph Nodes of Cattle without Cancer

“…5,6,12,16 Benign mesothelial cell inclusions have been reported, especially in mediastinal lymph nodes, in human beings 1,3,14,16 and in 3 dogs, 11 in association with pleural and pericardial effusion. When mesothelial cells are injured, adjacent mesothelial cells proliferate, detach from the basement membrane into the serosal fluid, and settle on the wound surface.…”

“…The tubular and papillary epithelioid cell formations that were observed in these cattle resemble the so-called benign glandular inclusions described in pelvic lymph nodes of women. 4,5,7,12 These inclusions are lined by ciliated cells like those of the endometrium or oviduct and are considered to be a metaplastic phenomenon of peritoneal mesothelium, which is derived from coelomic epithelium from which the Mullerian duct also originates. 4,5,7,12 In this study, some of the epithelioid cells that formed tubular and papillary structures had long slender microvilli, concentric perinuclear bundles of intermediate filaments, and cilia; these cells were adjacent to individual and aggregated epithelioid cells that were also considered to be mesothelial in origin.…”

“…4,5,7,12 These inclusions are lined by ciliated cells like those of the endometrium or oviduct and are considered to be a metaplastic phenomenon of peritoneal mesothelium, which is derived from coelomic epithelium from which the Mullerian duct also originates. 4,5,7,12 In this study, some of the epithelioid cells that formed tubular and papillary structures had long slender microvilli, concentric perinuclear bundles of intermediate filaments, and cilia; these cells were adjacent to individual and aggregated epithelioid cells that were also considered to be mesothelial in origin. The fact that some individual and aggregated epithelioid cells expressed fibronectin along the cell membrane or in the cytoplasm could indicate that individual epithelioid cells aggregate or proliferate in lymph nodes and then settle in nodal stroma.…”

Coexistent Isolated Tumor Cell Clusters of Infiltrating Lobular Carcinoma and Benign Glandular Inclusions of Müllerian (Endosalpingiosis) Type in an Axillary Sentinel Node

“…14 The presence of benign mullerian-type glandular inclusions with concurrent parenchymal breast disease is an exceedingly rare event, with 10 previous cases reported in the literature, 5 displaying definitive endosalpingiosis, 3,5,6 3 with microvilli suggestive of endosalpingiosis, 1 2 with serous change, 2,4 and 2 coexisting with nodal infiltrating ductal-type mammary carcinoma. 2,6 Although Fisher et al 15 described coexistent nodal epithelial inclusion cysts and lobular carcinoma occurring in a 57-year-old female involving 2 of 27 right-sided lymph nodes and Piana et al 6 reported the first case of endosalpingiosis with concurrent breast ductal carcinoma; here we report, to the best of our knowledge, the first case of coexistent invasive lobular carcinoma and endosalpingiosis in an axillary lymph node.…”

Benign Inclusions in Lymph Nodes

“…ducts (Hong et al, 1988). The epithelial cells found in the inclusions may have a variety of origins, namely: paramesonephric duct cells, salivary gland cells, breast tissue cells, thyroid follicle cells, squamous epithelial cells and mesothelial cells (Piana et al, 2005).…”