Benign mucous membrane pemphigoid. Response to therapy with cyclophosphamide

Abstract

From the

Oral cyclophosphamide without corticosteroids to treat mucous membrane pemphigoid

“…There are two CYC administration routes -oral and intravenous pulses; both have been used to treat patients with MMP. 1,[6][7][8][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Most studies investigating the effect of CYC in the treatment of MMP concentrated on ocular MMP, and CYC treatment was usually combined with systemic corticosteroids; hardly ever was the time period from the first CYC administration to clinical improvement mentioned. The results of Foster's study, which investigated CYC efficacy without corticosteroid adjunction, showed a good efficacy in ocular inflammation.…”

“…Treatment lasted 6 months in Foster's randomized trials 2 and between 12 and 18 months in the others. 8,10,14,17,23,24 The judgement criterion of CYC efficacy was ocular involvement regression, with the goal of obtaining white, noninflammatory eyes with arrest of fibrosis progression. No information on extraocular site outcomes was provided.…”

Management of autoimmune bullous diseases: Pharmacology and therapeutics

“…[121][122][123] In severe oral disease, as well as in cases of ocular, pharyngeal, or laryngeal involvement, systemic glucocorticoids in combination with cyclophosphamide are indicated. 124 Most patients have an excellent response, with a prolonged remission after treatment with the combination of prednisone (1 mg/kg/d) and cyclophosphamide (1 to 2 mg/kg/d). Prednisone is used for approximately 6 months, while cyclophosphamide is used for 18 to 24 months.…”

Long term results of systemic chemotherapy for ocular cicatricial pemphigoid

“…Control of inflammation and arrest of the cicatrizing process are, therefore, the goals of therapy in OCP. Previous studies of dermatologists and ophthalmologists caring for patients with CP have shown that it can be effectively treated with systemic immunosuppressive chemotherapy [1][2][3][4][5][6][7][8]. Two randomized, controlled clinical trials have established the efficacy and safety of chemotherapy for OCP and have allowed formation of recommended therapeutic guidelines [1].…”