Benign mixed tumour of the breast and breast skin, two cases with diagnostic difficulties

Abstract

SUMMARYWe present two cases of pleomorphic adenoma, one that developed in the breast parenchyma and the other in the breast skin, with their histopathological differential diagnosis. BACKGROUND

Skin Mixed Tumor of Right Nose

“…4 Mainly occurs in the head, face, neck, often involving nose, cheek, upper lip, and other parts; occasionally occurs in the trunk, limbs, perineum, and other parts. 5,6 Histopathologic manifestations are composed of epithelial components (various cellular components such as eccrine, apocrine, sebaceous, and hair) and interstitial components (cartilage-like or mucus-like matrix). Skin mixed tumor is a mass with clear boundary under low magnification.…”

“…It is more common in men than women and more common in people between the ages of 20 and 40 4. Mainly occurs in the head, face, neck, often involving nose, cheek, upper lip, and other parts; occasionally occurs in the trunk, limbs, perineum, and other parts 5,6…”

Pleomorphic adenoma of the breast with cytologic atypia on cytopathology: A potential diagnostic pitfall and literature review

“…A comparison of the staining qualities of the stroma in PA to those of mucinous carcinoma has shown that the mucin in PA will be lost on alcian blue with hyaluronidase treatment, whereas it will be preserved in mucinous carcinoma. This feature may be used in the distinction of the two entities 21 …”

“…This feature may be used in the distinction of the two entities. 21 Other diagnoses in the differential included metaplastic carcinoma, fibroepithelial neoplasms of the breast, papillomas, and other salivary gland-type neoplasms.…”

“…Papillomas may be associated with chondroid metaplasia of its stroma, thus bringing this entity into the differential diagnosis. 21 However, the epithelium of a papilloma would be arranged in papillary fronds and associated with myoepithelial cells. Apocrine metaplasia may also be a feature of papillomas.…”