Benign metastasizing uterine leiomyoma with lung metastasis: problems of diagnosis and treatment

Pechetov, A A; Lednev, A.N.; Ratnikova, N. K.; Volchanskii, D A

doi:10.17116/hirurgia202009185

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…We should distinguish ovarian leiomyoma from ovarian fibroma, ovarian sex gonad stromal tumor, and leiomyosarcoma. Although MRI has advantages over computed tomography (CT) in soft tissue resolution, the MRI findings of ovarian leiomyoma and ovarian sex cord stromal tumor lack specificity 13 . Studies have shown that the MRI signals of primary ovarian leiomyoma are similar to those of uterine leiomyoma 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Although MRI has advantages over computed tomography (CT) in soft tissue resolution, the MRI findings of ovarian leiomyoma and ovarian sex cord stromal tumor lack specificity. 13 Studies have shown that the MRI signals of primary ovarian leiomyoma are similar to those of uterine leiomyoma. 14 There have been no sensitive serum tumor markers for differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian leiomyoma accompanied by a neglected abdominal wall leiomyoma: A case report and literature review

Li,

Sui,

Sun

2024

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ovarian leiomyoma accompanied by a neglected abdominal wall leiomyoma: A case report and literature review

Li,

Sui,

Sun

2024

Clinical Case Reports

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“…To date, there are no standardized guideline-based treatments for BML. However, patients usually can have a favorable prognosis to accept a comprehensive treatment, based on the indolent nature of BML ( 34 ). More importantly, long-term surveillance of sex hormone level and imaging follow-ups are required to monitor disease progression ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Concurrent Benign Metastasizing Leiomyoma in the Abdominal Wall and Pelvic Cavity: A Case Report and Review of the Literature

Wang

et al. 2022

Front. Surg.

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Benign metastatic leiomyoma (BML) is a histologically benign disease with invasive biological behavior. Most patients are women of childbearing age with a history of uterine leiomyoma. The progress of the disease is relatively slow, the prognosis is good, and most patients can survive for a long time. The lung is the common metastatic site, and BML with metastatic lesions outside the lung is very rare. A 37-year-old woman with multiple BML in the abdominal wall and pelvic cavity after uterine leiomyoma surgery was admitted to our hospital. Combined with the clinical data of this case and reviewing the relevant literature, this paper discusses the pathological characteristics, diagnosis, differential diagnosis, and treatment of BML.

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“…Among women diagnosed with uterine leiomyoma, 15-30% have symptoms of varying severity, including pain syndrome, infertility, dysfunction of adjacent organs, abnormal uterine bleeding, anemia, and a number of other severe complications [7]. Despite their benign nature, leiomyomas are able to metastasize, penetrating into various tissues of the body outside the uterus, in particular, into the lungs [8].…”

Section: Introductionmentioning

confidence: 99%

Novel Approaches to Possible Targeted Therapies and Prophylaxis of Uterine Fibroids

Kuznetsova,

Tonoyan,

Trubnikova

et al. 2023

Diseases

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Uterine leiomyomas are the most common benign tumors in women of childbearing age. They may lead to problems of conception or complications during the gestational period. The methods of treatment include surgical (myomectomy and hysterectomy, embolization of arteries) and therapeutic treatment (ulipristal acetate, leuprolide acetate, cetrorelix, goserelin, mifepristone). Both approaches are efficient but incompatible with pregnancy planning. Therefore, there is a call for medical practice to develop therapeutical means of preventing leiomyoma onset in patients planning on becoming pregnant. Based on the analysis of GWAS data on the search for mononucleotide polymorphisms associated with the risk of leiomyoma, in meta-transcriptomic and meta-methylomic studies, target proteins have been proposed. Prospective therapeutic treatments of leiomyoma may be based on chemical compounds, humanized recombinant antibodies, vaccines based on markers of the uterine leiomyoma cells that are absent in the adult organism, or DNA and RNA preparations. Three different nosological forms of the disease associated with driver mutations in the MED12, HMGA2, and FH genes should be considered when developing or prescribing drugs. For example, synthetic inhibitors and vaccines based on matrix metalloproteinases MMP11 and MMP16 are expected to be effective only for the prevention of the occurrence of MED12-dependent nodules.

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Benign metastasizing uterine leiomyoma with lung metastasis: problems of diagnosis and treatment

Cited by 6 publications

References 15 publications

Ovarian leiomyoma accompanied by a neglected abdominal wall leiomyoma: A case report and literature review

Ovarian leiomyoma accompanied by a neglected abdominal wall leiomyoma: A case report and literature review

Concurrent Benign Metastasizing Leiomyoma in the Abdominal Wall and Pelvic Cavity: A Case Report and Review of the Literature

Novel Approaches to Possible Targeted Therapies and Prophylaxis of Uterine Fibroids

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