Benign Metastasizing Leiomyoma: A Rare Metastatic Lesion in the Right Ventricle

Metastasizing Leiomyoma to Heart

“…1 Overall, smooth muscle tumors of the heart are extremely rare. Three different clinical settings for cardiac smooth muscle tumors have been reported: intravenous cardiac extension of pelvic leiomyomas, 2 benign metastasizing leiomyomas from the uterus, 1,3,4 and primary cardiac leiomyomas and leiomyosarcomas. 5 Here we report a rare entity of metastasizing leiomyoma to the heart with review of the literature.…”

A Diffuse Pulmonary Presentation of Benign Metastasizing Leiomyomas Fawwaz R Shaw

“…In addition they characteristically do not have nuclear pleomorphism and necrosis is usually absent. These features along with the absence of pseudocyst formation differentiate them histologically from their malignant counterparts -the leiomyosarcoma [1][2][3][4]. There is no reported spontaneous transformation to leiomyosarcomas.…”

“…These include intraperitoneal seeding at the time of uterine myomectomy or hysterectomy, lymphatic or hematogenous spread, hormonal stimulus and coelomic metaplasia as a result of transformation of mesothelial mesenchymal cells under hormonal stimulus [2][3][4][5][6]. Regardless of the means by which these tumors arise, their behavior in many ways mimics the behavior of endometriosis.…”

“…Once the diagnosis is established, resection of large solitary pulmonary masses may improve symtomatology and provide cure [2,3,6]. Recurrence following excision of a single lesion has not yet been described in the literature.…”

Pulmonary benign metastasizing leiomyoma: an extremely rare case

“…They are incidentally noticed on chest radiography as bilateral benign lesions proliferating from smooth muscles. Although most commonly seen in the lungs, other sites of involvement have been reported in the literature including lymph nodes, omentum, pelvis, abdomen, mediastinum, vertebra, cranium, skeletal muscle, skin, vena cava inferior, right atrium, breast, trachea, esophagus, liver and adrenal glands (2,3). Patients with pulmonary BML are almost always asymptomatic, though some patients present with cough or breathlessness not affecting pulmonary function.…”