Benign melanocytic lymph node deposits in the setting of giant congenital melanocytic nevi: the large congenital nodal nevus

Bowen, Anneli R.; Duffy, Keith L.; Clayton, Frederic; Andtbacka, Robert H.I.; Florell, Scott R.

doi:10.1111/cup.12580

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…2,4,7 The incidence of BCN has been described in as high as 25% of excised lymph nodes (including SLN biopsies as well as lymphadenectomies) but has more often been reported between 0% and 12%. 2,4,[6][7][8][9][10][11][12][13][14][15][16] BCN have been identified in all lymph node basins but are most frequently described in the axilla. 2,4,5 There are two major hypotheses regarding the presence of BCN: the first proposes that they occur as neural crest progenitors, which migrate and arrest in LNs and the second that benign cutaneous melanocytic lesions are transported through the lymph system (termed benign mechanical transport or benign metastasis).…”

Section: Introductionmentioning

confidence: 99%

“…2,4,5 There are two major hypotheses regarding the presence of BCN: the first proposes that they occur as neural crest progenitors, which migrate and arrest in LNs and the second that benign cutaneous melanocytic lesions are transported through the lymph system (termed benign mechanical transport or benign metastasis). 2,4,5,[8][9][10]12,15,17 Differentiating BCN from micrometastasis of cutaneous melanoma can be challenging, and relies on morphology as well as immunohistochemical (IHC) assays and stains. 4,10,[18][19][20] The clinical significance and prognostic implication of incidentally detected BCN in SLNs of patients with melanoma remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of BCN has been described in as high as 25% of excised lymph nodes (including SLN biopsies as well as lymphadenectomies) but has more often been reported between 0% and 12% 2,4,6‐16 . BCN have been identified in all lymph node basins but are most frequently described in the axilla 2,4,5 .…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of SLN benign capsular nevi in patients with melanoma

Yamashita

Pockaj

Bagaria

et al. 2020

Journal of Surgical Oncology

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Background: Benign capsular nevi (BCN) are not infrequent in sentinel lymph nodes (SLN) of patients with melanoma. Their prognostic significance is unknown and the literature is limited. This study evaluated the clinical significance of incidentally found BCN in these patients. Methods: A multi-institutional retrospective review of patients undergoing SLN biopsy for cutaneous melanoma between 2000 and 2016. Patients were divided into the following groups: (a) negative SLN and no BCN, (b) negative SLN and presence of BCN, (c) positive SLN seen only on immunohistochemistry (IHC), and (d) positive SLN via hematoxylin and eosin (H&E). Outcomes measured were overall survival and any recurrence. Results: A total of 1253 patients were identified (group 1 = 978, group 2 = 56, group 3 = 32, and group 4 = 187). Fifty-seven percent were male and the mean age was 59.3 years. BCN was identified in 77 patients (6.2%), of which the majority was in the node-negative group (72%). Multivariable analysis showed that BCN was associated with lower recurrence rates, though not statistically significant (hazard ratio [HR] = 0.5; P = .06). IHC-and H&E-positive SLNs were associated with a higher risk of recurrence (HR = 2.4; P = .02 and 2.0, P < .0001, respectively). Conclusion: Patients with BCN and negative SLN had lower recurrence rates than patients with negative SLN and no BCN. Our data suggest a possible protective effect against recurrence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of SLN benign capsular nevi in patients with melanoma

Yamashita

Pockaj

Bagaria

et al. 2020

Journal of Surgical Oncology

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“…36,37 Another aspect of the CMN, especially, giant type, is the presence of benign nevus cells in regional lymph nodes. 38,39 These nests are composed of small nevus cells similar to those seen in the CMN. However, we have seen examples in which the distinction from metastatic melanoma was a challenging one.…”

Section: Congenital Melanocytic Nevusmentioning

confidence: 90%

Common and not so Common Melanocytic Lesions in Children and Adolescents

2018

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The acquired melanocytic nevus is the most common lesion encountered by pediatric pathologists and dermatopathologists in their daily practice. In most cases, there are few difficulties in histopathologic diagnosis. However, it is the acquired melanocytic lesion known as the Spitz nevus, with its intrinsic atypical features which becomes the challenge since it exists along a histopathologic and biologic continuum from the atypical Spitz tumor to spitzoid melanoma. The frustration with some of these spitzoid lesions is that even the "experts" cannot agree as to the differentiation of one from the other even at the level of molecular genetics. Other melanocytic lesions are discussed including the congenital melanocytic nevus with its proliferative nodule(s) and melanoma as the ultimate complication. Although uncommon, cutaneous melanoma in the first 2 decades is emerging as a clinical problem especially in young women in the second decade of life. These are ultraviolet-associated neoplasms whose histopathologic and prognostic features are identical to the adult experience. Considerable progress has been made over the past 15 to 20 years in our understanding of cutaneous melanocytic lesions, but gaps still exist in the important group of spitzoid lesions. It can also be anticipated that more cutaneous melanomas in children will be seen in the future based upon epidemiologic studies.

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“…56 Benign capsular naevus cells stain positively for MART-1, 57 S-100 and Melan-A but, importantly, they are negative for HMBA-45. 58,59 Intra-capsular melanoma metastases are distinguished from benign naevus cells in that they exhibit marked atypia, mitotic figures, positive HMB-45 staining and destruction of the lymph node capsule. Capsular naevus cells can be further distinguished from melanoma cells through their positive staining for p16.…”

Section: The Failure To Offer Slnbmentioning

confidence: 99%

Malignant melanoma: Claims and controversies

Stone

2018

Journal of Patient Safety and Risk Management

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Malignant melanoma is a common cancer in young people and its incidence is rising in the UK. The management of the disease is evolving, with new approaches to the treatment of locally advanced and systemic disease in particular being rapidly developed. Sentinel node biopsy is a valuable treatment option for the staging of melanoma, and completion lymphadenectomy in node-positive patients improves local disease control. However, early clearance of occult microscopic nodal disease has not been proven to confer a melanoma-specific survival advantage. Delays in the diagnosis and treatment of melanoma lead to claims being brought in negligence, but establishing causation in such cases can be difficult.

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Benign melanocytic lymph node deposits in the setting of giant congenital melanocytic nevi: the large congenital nodal nevus

Cited by 17 publications

References 18 publications

Clinical significance of SLN benign capsular nevi in patients with melanoma

Clinical significance of SLN benign capsular nevi in patients with melanoma

Common and not so Common Melanocytic Lesions in Children and Adolescents

Malignant melanoma: Claims and controversies

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