Benign lymphoepithelial cysts of parotid and submandibular glands in a HIV-positive patient

Shivhare, Peeyush; Shankarnarayan, Lata; Jambunath, Usha; Basavaraju, Sowbhagya Malligere

doi:10.4103/0973-029x.157213

Cited by 16 publications

(12 citation statements)

References 8 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The immunohistochemical studies on a LEC in HIV-infected patients have revealed HIV-1 p24 in residual dendritic cells of lymphoid follicles (follicular dendritic reticulum cells) and follicular and interfollicular macrophages [9,10,12]. Some authors have shown that the lymphoepithelial cyst contained a large amount of HIV-1 p24 and RNA copies, suggesting this lesion to be a reservoir of HIV [2,12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat

Dolka

Tomaszewski

Wola

et al. 2020

Animals

View full text Add to dashboard Cite

The lymphoepithelial cyst (LEC) of the major salivary gland is a rare lesion described in medical literature. It is found in human immunodeficiency virus (HIV)-infected patients and considered an early manifestation of this infection. Despite the variety of theories, the origin of this lesion remains controversial. No veterinary studies on LEC have been published so far. This study is the first-ever that aims to describe histopathological, histochemical, and immunohistochemical features of a LEC located adjacent to the salivary gland of a goat. The goat proved seropositive for the small ruminant lentivirus, showed clinical signs of caprine arthritis-encephalitis, and had caprine arthritis-encephalitis virus (CAEV)-infected cells in the lung. The histopathology revealed a cystic lesion lined mainly with squamous epithelium surrounded by a lymphoid component, containing a mucus-negative material and a few nonbirefringent structures corresponding to amylase crystalloids. Using immunohistochemistry, CAEV-positive cells were detected in macrophages, LEC epithelial cells, and the salivary gland. The B cells were mainly in the germinal centres, the intraepithelial lymphocytes expressed CD3 and Bcl-2, and the proliferative activity was low. This study showed that LEC had many similar histological and immunohistochemical features to those seen in humans. However, further studies are required in this respect.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Based on our observations, we can only speculate that this lesion may be very rare, as it has been reported in humans. The incidence of the salivary LEC corresponded to less than 6% of the HIV-infected patients, but the exact incidence of the LEC in non-HIV patients is unknown [2,8].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat

Dolka

Tomaszewski

Wola

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…3 Though differential diagnosis of salivary gland disease (SGD) in seropositive patients would include diffuse infiltrative lymphocytosis syndrome (DILS), parotitis, intraparotid lymphadenopathy, adenoid cystic carcinoma, Kaposi sarcoma, and lymphoma; their varied clinical, radiological, and microscopic features will differentiate them from BLECs. 6 Literature review has no mention of these entities in HIV negative patients.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelial cyst of the parotid in HIV negative individual: a case report

et al. 2019

View full text Add to dashboard Cite

Benign Lymphoepithelial cyst (BLEC) of parotid gland are more common in HIV positive patients and is rare in HIV negative individuals. We present a 16-year-old HIV negative female who presented with a painless, gradually increasing swelling in the left parotid region. Excisional biopsy was done and HPE showed benign lymphoepithelial cysts. The rarity of this lesion in a HIV negative patient is the main reason for reporting this case.

show abstract

“… 7 These cysts serve as a reservoir of HIV-1 p24 antigen and RNA copies that are about 1000-fold higher than plasma concentrations. 6 HIV has a predilection for lymphoid tissue and elevated concentrations of HIV can be found within these nodes. 8…”

Section: Discussionmentioning

confidence: 99%

HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining

Sekikawa¹,

Hongo

2017

BMJ Case Reports

View full text Add to dashboard Cite

Approximately 1%–10% of patients with HIV infection have been reported to have salivary gland enlargement. Parotid swelling in patients with HIV is often associated with salivary gland disease, including benign lymphoepithelial cysts (BLECs). The presence of BLEC can serve as an indicator of HIV infection, and the diagnosis of HIV-associated BLEC is usually based on clinical course, HIV confirmatory blood testing, such as western blot or viral detection, and imaging studies, but not on biopsies or immunostaining. To exclude other diseases such as tuberculosis and malignant lymphoma and to further improve the diagnostic accuracy of BLEC, the detection of the HIV-1 p24 antigen by immunohistochemistry is a useful diagnostic method. We report a case of a 65-year-old Japanese man with swelling of the parotid glands and HIV-associated BLEC confirmed via HIV-1 p24 immunohistochemical staining.

show abstract

Benign lymphoepithelial cysts of parotid and submandibular glands in a HIV-positive patient

Cited by 16 publications

References 8 publications

Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat

Lymphoepithelial Cyst of the Salivary Gland in a Small Ruminant Lentivirus-Positive Goat

Lymphoepithelial cyst of the parotid in HIV negative individual: a case report

HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining

Contact Info

Product

Resources

About