Benign Lymphocytomas Clinical and Histologic Aspects

Wantzin, Gunhild Lange; Petri, Jens; Nielsen, Merete Bohn; Thomsen, Kristian

doi:10.1007/978-3-642-68363-3_26

Cited by 8 publications

(5 citation statements)

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“…An important finding was that seven HTLV antibody positive patients had early mycosis fungoides stage I with non-diagnostic histology and in four of five of these patients hyperdiploid cell clones were determined. No alterations in single cell DNA or phenotype of the peripheral blood in these early stage patients have been found (12,21). Thus.…”

Section: Discussionmentioning

confidence: 72%

Human T-cell leukemia virus in cutaneous T-cell lymphoma in Denmark. A possible association of HTLV and aneuploidy

Lange Wantzin,

Saxinger,

Woods

et al. 1984

Acta Derm Venereol

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Cutaneous T-cell lymphomas (CTCL) are neoplasias of mature T-cells and comprise Sezary syndrome, mycosis fungoides and some cases of lymphomatoid papulosis. Clinically this group of disorders differ from the more aggressive neoplasias of mature T-cells known as adult T-cell leukemia/lymphoma and T-cell lymphosarcoma leukemia which are associated with human T-cell leukemia virus (HTLV). We have found that of 68 patients from Denmark with CTCL ten were positive for HTLV antibodies and that the neoplastic T-cells from skin specimens in seven of eight HTLV-antibody positive patients studied by DNA flow cytometry exhibit DNA aneuploidy. Either one or two hyperdiploid cell clones were present. Aneuploidy was found in two patients with histologically verified mycosis fungoides, in four patients with histological non-diagnostic mycosis fungoides, and in one patient with lymphomatoid papulosis. The present data indicate that further seroepidemiologic survey studies of cutaneous T-cell lymphomas should include the early histological non-diagnostic stages, especially when aneuploidy is present.

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Section: Discussionmentioning

confidence: 72%

Human T-cell leukemia virus in cutaneous T-cell lymphoma in Denmark. A possible association of HTLV and aneuploidy

Lange Wantzin,

Saxinger,

Woods

et al. 1984

Acta Derm Venereol

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“…The possibility of reactive proliferations or psetidolympho- mas should also be kept in mind when considering the diagnosis of PCI. Classical criteria for the diagnosis of pseudolymphomas include top-heavy infiltrates and mixed cell infiltrates (18)(19)(20)(21)(22). Reactive lymphoid follicles may be present and adnexa are spared by the neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous immunocytoma: report of an unusual case with secondary spreading to the gastrointestinal tract

1997

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Cutaneous immunocytoma are low-grade B-cell lymphomas, which affect the skin either primarily or secondarily. Primary cutaneous immunocytomas usually present with one or a small number of lesions, mainly in the extremities. They generally remain confined to the skin. Histologically, there are polymorphous infiltrates of cells, in which the presence of monoclonal plasma cells is characteristic. We describe a case of cutaneous immunocytoma with secondary spread to the gastrointestinal tract.

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“…In contrast, Grenzzone, top-heavy, mixed cellular infiltrates, germinal center formation, vascular proliferation, and fibrosis suggest benign lesions. However, it is known that fully developed lymph follicle structures exist in only 10% of benign lympho-proliferative disorders (12) and that benign lymphoproliferative disorders of the skin may demonstrate considerable cytological atypicality (1,2,13,14).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Differential Diagnosis between Lymphocytoma Cutis and Malignant Lymphoma in Paraffin‐embedded Sections

Toyota

Matsuo

Iizuka

1991

The Journal of Dermatology

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A panel of monoclonal antibodies (Leucocyte Common Antigen [CD45], LN-1 [CDw75], LN-2 [CD74], LN-3, L-26, UCHL-1 [CD45RO] and MT-1) which identify B and T cell surface markers were applied to benign lymphocytoma cutis and malignant lymphoma of the skin in paraffin-embedded sections. In five cases of lymphocytoma cutis, both B and T cell markers were positive, consistent with the polyclonality of the proliferative lymphocytes. In contrast, in two cases of B cell lymphoma, only the B cell markers were positive, consistent with the monoclonality. Furthermore, the immunohistochemistry clarified lymph follicle structures of lymphocytoma cutis. These were occasionally not evident in routine hematoxylin and eosin stained sections. Thus an immunologic phenotyping study combined with other appropriate criteria for histologic evaluation and clonal gene rearrangement analysis appears to be useful in distinguishing reactive from neoplastic lymphoid lesions of the skin.

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Benign Lymphocytomas Clinical and Histologic Aspects

Cited by 8 publications

References 1 publication

Human T-cell leukemia virus in cutaneous T-cell lymphoma in Denmark. A possible association of HTLV and aneuploidy

Human T-cell leukemia virus in cutaneous T-cell lymphoma in Denmark. A possible association of HTLV and aneuploidy

Primary cutaneous immunocytoma: report of an unusual case with secondary spreading to the gastrointestinal tract

Immunohistochemical Differential Diagnosis between Lymphocytoma Cutis and Malignant Lymphoma in Paraffin‐embedded Sections

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