Benign Large-cell Calcifying Sertoli Tumor of the Testis in a 13-Year-Old Male Patient Treated With Partial Orchiectomy

Tracey, Anthony J.; Cerwinka, Wolfgang H.

doi:10.1016/j.urology.2017.05.023

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…The LCCSCT, one of the rarest sex cord-stromal tumors of the testis, was initially described by Lange et al6 in 1960 and then formally introduced as a distinct entity by Proppe and Scully in 1980 5. To date, 45 clinically benign,1,5,9,12,25,27,29–45 53 clinically ambiguous,1,16,27,36,38,43,46–78 and 17 clinically malignant1–3,5,23–28 cases have been reported in the English language literature, including this series, according to our comprehensive review (Tables 2, 3, Supplementary Table 1, Supplemental Digital Content 1, http://links.lww.com/PAS/B288).…”

Section: Discussionmentioning

confidence: 82%

Large Cell Calcifying Sertoli Cell Tumor

Al‐Obaidy

Idrees

Abdulfatah

et al. 2021

American Journal of Surgical Pathology

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Section: Discussionmentioning

confidence: 82%

Large Cell Calcifying Sertoli Cell Tumor

Al‐Obaidy

Idrees

Abdulfatah

et al. 2021

American Journal of Surgical Pathology

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“…These aspects are caused by a male-specific tumor named large cell calcifying Sertoli cell tumor (LCCSCT) (70). A total of 30-40% of cases are associated with hereditary syndromes such as PJS and Carney complex while 60-70% of all LCCSCT represent sporadic forms (71). This is an extremely rare entity derived from sperm cord cells (70).…”

Section: Endocrine Aspects In Malesmentioning

confidence: 99%

Peutz‑Jeghers syndrome: Skin manifestations and endocrine anomalies (Review)

et al. 2021

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Peutz-Jeghers syndrome (PJS), a rare autosomal dominant serine/threonine kinase 11 (STK11)/ liver kinase B1 (LKB1) gene-related genodermatosis, is characterized by oral hyperpigmentation (OHP); multiple gastro-intestinal mucosal benign hamartomatous polyps causing local bleeding, occlusion, intussusception, post-resection small bowel syndrome, associated increased risk of small intestinal cancer (incidence during the third decade); and 76% cumulative higher risk than the global population of developing non-gastrointestinal tumors (female predominance) including ovarian/testicular neoplasia, pancreatic and gynecologic (breast, uterus, ovarian) cancers. Suggestive PJS-associated OHP requires STK11 genetic testing. Abdominal pain in an OHP patient may be related to PJS-associated polyps. Other features include focal depigmentation followed by hyperpigmentation, and xeroderma pigmentosum-like lesions. The severity of the dermatological findings is correlated with gastrointestinal polyps. The STK11 gene is linked to reserve of primordial follicles, polycystic ovary syndrome, female fertility, and spermatogenesis. PJS is associated with 2 types of ovarian sex-cord stroma tumors (SCSTs): annular tubules (SCTATs) and pure Sertoli cell tumors. SCSTs accounts for 8% of ovarian cancer and SCTATs represents 2% of SCST, which may be associated with the overproduction of progesterone. PJS-SCTAT vs. non-PJS-SCTAT reveals bilateral/multifocal, small tumors with a benign behavior vs. a unique ovarian, large tumor with increased malignant/metastasis risk. Male precocious puberty is due to large cell calcifying Sertoli cell tumors (LCCSCTs). Notably, 30-40% of LCCSCTs are caused by PJS or Carney complex. PJS-LCCSCT is not aggressive, but it may be bilateral/multifocal, with the ultrasound hallmark being micro-calcifications. Testicular, intra-tubular large cell hyalinizing Sertoli cell tumor is the second testicle neoplasia in PJS. The skin and mucosal lesions are useful markers of PJS, assisting with the early identification of hamartomatouspolyps and initiation of serial surveillance of ovarian, or testicular neoplasia.

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“…Most of them are benign, but a few malignant cases have been reported [1,[4][5][6]. They were first identified by Proppe and Scully in 1980, and since then, almost 100 cases have been described in the literature [4,[7][8][9][10][11][12][13][14]. These tumors are usually seen in young adults and can affect one or both testicles in a multifocal form causing microcalcifications [5].…”

Section: Introductionmentioning

confidence: 99%

Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis

Bardisi

Khabaz

Al-Maghrabi

2020

Case Reports in Pathology

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Large cell calcifying Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date. Most of the tumors are benign with a few malignant cases, and aggressive behavior is infrequent. These tumors are a type of Sertoli cell tumor, and these tumors comprise less than 0.3% of all testis tumors in Saudi Arabia. They usually occur in boys and young adults and can affect one or both testicles in multifocal form causing microcalcifications. A 28-year-old male visited our hospital with left testis pain. Physical examination of the scrotum revealed that both testicles were normal sized with no palpable mass. Ultrasonography evaluation revealed grade 3 left varicocele and an incidental 9 mm calcified mass in the right testicle, which was further confirmed by MRI. Partial orchiectomy was performed. Clinical data, radiological studies, and morphological and immunohistochemical characteristics were analyzed.

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Benign Large-cell Calcifying Sertoli Tumor of the Testis in a 13-Year-Old Male Patient Treated With Partial Orchiectomy

Cited by 6 publications

References 10 publications

Large Cell Calcifying Sertoli Cell Tumor

Large Cell Calcifying Sertoli Cell Tumor

Peutz‑Jeghers syndrome: Skin manifestations and endocrine anomalies (Review)

Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis

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