Benign fibrous histiocytoma arising from the intercostal space

Abstract

Benign fibrous histiocytoma is a tumor of unknown etiology that is believed to be of mixed fibroblastic and histiocytic origin. Deep benign fibrous histiocytomas are most commonly found in the lower limbs or the head and neck region; it is relatively rare that they are seen in the intercostal space. Only six case reports of this entity are described in the literature. We report a 20-year-old woman who suffered from a painless swelling in the left chest wall, with a computed tomographic correlation. The lesion was totally excised, and histopathology revealed a benign fibrous histiocytoma. This is the first case of a benign fibrous histiocytoma that arose from the intercostal space reported in the English-language literature. The six cases reported in the medical literature are also discussed.

Benign fibrous histiocytoma arising from the right shoulder: Is immunohistochemical staining always required for a definitive diagnosis?

“…Wide excision is defined as excision of the mass with a confidence margin of 1-2 cm; however, consensus has not been reached on this issue. 4,5 Studies can be conducted about adequate surgical margin with intraoperative frozen section. However, the centers we work must have facilities required to do this.…”

“…1 BFH constitutes a diagnostic dilemma because the lesions share common clinical symptoms, radiological characteristics, and histological features with benign and malignant lesions, such as nonossifying fibromas, giant cell tumors, fibrous dysplasia, aneurysmal bone cysts, osteoblastomas, eosinophilic granulomas, chondrosarcomas, rhabdomyosarcomas, desmoid tumors, DFSPs, and MFHs. 4 Therefore, a definitive diagnosis of BFH should be made by evaluating the patient's symptoms, tumor location, radiological characteristics, histopathological features, and immunohistochemical staining results.…”

“…Although the soft tissue in the dermis constitutes the predominant origination site, the tumor may also stem from subcutaneous tissue, bone, and, rarely, parenchymal organs in <1-2% of cases. [1][2][3][4] Establishing a definitive diagnosis is straightforward in tumors located in the dermis; however, a BFH originating from the deep subcutaneous tissues can frequently be confused with dermatofibrosarcoma protuberans (DFSP) and malignant fibrous histiocytoma (MFH). Recently, the differentiation among these tumors has been improved with immunohistochemical staining methods.…”

A Rare Localization of Subcutaneous Dermatofifibroma: Case Report

“…3 It was found by Dahlin for the first time. 5 It is seen in men 2.5 times more often. 4,6 Our patient was a 26 year-old female patient.…”

Primary benign fibrous histiocytoma of bone: A case report

“…BFH is a mesenchymal tumor that is believed to originate from fibroblasts and histiocytes. Nonetheless, its lineage remains vague and its etiology unknown [9,10] . The giant cells in BFH tend to have fewer nuclei than those found in osteoclastoma or giant cell tumor (GCT).…”