Benign fibrous histiocytoma: A rare case involving jaw bone

Shoor, Hitesh; Pai, Keerthilatha M.; Shergill, Ankur Kaur; Kamath, Abhay Taranath

doi:10.4103/0976-237x.166828

Cited by 9 publications

(7 citation statements)

References 9 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BFH has a tendency to recur [13,26,27]. BFH of the jaws is unusual, can be painful and demonstrates progressive expansion of the posterior mandible [28,29].…”

Section: Discussionmentioning

confidence: 99%

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

Wilkinson

Merkourea

Gopalakrishnan

et al. 2020

Head and Neck Pathol

View full text Add to dashboard Cite

Primary intraosseous xanthomas of the jaws (PIXJ) are rare and predominantly affect the posterior mandible (86%) of normolipemic patients, with a mean age of 30 years and no gender predilection. Clinically, PIXJ exhibit indolent biologic behavior; curettage is considered treatment of choice. Only 36 PIXJ have been reported. Apoptosis-related hyaline globules (HGs), also known as "thanatosomes", have not been previously reported in PIXJ. Cases diagnosed as xanthoma of bone were retrieved. Six cases fulfilling currently accepted criteria were identified and their clinicopathologic and immunohistochemical properties are presented herein. Mean age for PIXJ was 21.8 years (range = 12-33) and F:M ratio = 2:1. All cases presented as well-demarcated, unilocular or multilocular radiolucencies. Microscopically, PIXJ featured sheets of lipid-laden macrophages with eosinophilic or foamy cytoplasm. A secondary fibroblastic population lacking storiform pattern was evident in two cases. Adipocytes (3/6), peripheral neurovascular bundles (1/6), bone fragments (3/6) and dystrophic calcifications (3/6) were observed enclosed by the xanthoma cells. Notably, one case exhibited numerous, spherical, eosinophilic HGs containing apoptotic nuclei. PIXJ were consistently CD68(+) and negative for CD1α and S100. CD45 decorated lymphocytes and the membrane of foamy histiocytes. Xanthoma cells stained for lysozyme and plasma proteins including alpha-1 antitrypsin (AAT), IgG and IgA in one probed case. HGs were lysozyme(+), AAT(+), IgG(+), IgA(+), PAS(+) and diastase-resistant, and fuchsinophilic with Masson's trichrome. PIXJ represent infrequent, solitary, mandibular lesions with a predilection for the second and third decade of life. Thanatosomes associated with cell injury and death can be present in PIXJ.

show abstract

“…BFH has a tendency to recur [13,26,27]. BFH of the jaws is unusual, can be painful and demonstrates progressive expansion of the posterior mandible [28,29].…”

Section: Discussionmentioning

confidence: 99%

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

Wilkinson

Merkourea

Gopalakrishnan

et al. 2020

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Histopathologically, the foam cells are usually seen in small focal clusters and the dominant microscopic appearance is of a spindle cell proliferation arranged in whorls and storiform fascicles [14][15][16]. Thick collagen band entrapment and multinucleated giant cells are almost always seen [14][15][16]. Hemorrhage and hemosiderin pigment may also be found [14].…”

Section: Discussionmentioning

confidence: 99%

“…Jaw lesions may or may not be painful but show progressive expansion of the posterior mandible including the angle and ramus area [15,16]. Histopathologically, the foam cells are usually seen in small focal clusters and the dominant microscopic appearance is of a spindle cell proliferation arranged in whorls and storiform fascicles [14][15][16]. Thick collagen band entrapment and multinucleated giant cells are almost always seen [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…Pain is the most frequent presenting symptom at these locations [14]. Jaw lesions may or may not be painful but show progressive expansion of the posterior mandible including the angle and ramus area [15,16]. Histopathologically, the foam cells are usually seen in small focal clusters and the dominant microscopic appearance is of a spindle cell proliferation arranged in whorls and storiform fascicles [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Central Xanthoma of the Jaw Bones: A Benign Tumor

Rawal

Chandra

Hall

2016

Head and Neck Pathol

View full text Add to dashboard Cite

Extragnathic xanthomas are seen in the bones or as soft tissue masses. They are often associated with hyperlipidemia and are considered as reactive or metabolic lesions. Only 19 cases of xanthomas of the jaws have been reported so far in the English literature. A total of ten cases of central xanthoma of the jaw bones were identified from the Oral and Maxillofacial Pathology biopsy services of the University of Washington and the Tufts University School of Dental Medicine, between the years 2000-2016. The demographic and clinical information on these cases was tabulated logically on the basis of age, gender, location and presence or absence of symptoms, extragnathic lesions and serum hyperlipidemia. Radiographic and histopathological features were also examined. The findings in these cases were correlated with those available from the previously reported cases. Majority of cases are seen in the second and third decades of life. There is no gender predilection. Jaw lesions presented as solitary radiolucencies with a predilection for the posterior mandible. Unlike maxillary lesions, pain and expansion are inconsistent findings in mandibular lesions. Jaw lesions are not associated with extragnathic bone or soft tissue involvement or a hyperlipidemia. The central xanthoma of the jaws is a unique benign tumor. Histopathologically, many other jaw lesions contain variable numbers of foamy histiocytes. Therefore, a diagnosis of a central xanthoma of the jaws must be made after excluding all other such histiocyte containing lesions. This requires correlation of histopathological findings with clinical and radiographic features.

show abstract

“…Most bony BFHs occur in the pelvic bone, femur and tibia, which share identical histological characteristics with cutaneous BFH (5)(6)(7)(8). However, mandibular involvement of BFH is rare and only 11 cases have been reported to date (5,7,(9)(10)(11)(12)(13)(14)(15)(16). The present study reported a case of mandibular multiple BFH treated at the Affiliated Hospital of Stomatology, Sun Yat-Sen University (Guangzhou, China), who was followed up for 46 months.…”

Section: Introductionmentioning

confidence: 72%

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature

et al. 2022

View full text Add to dashboard Cite

Benign fibrous histiocytoma (BFH) mostly occurs on the skin of the extremities, while it is unusual to manifest on the bone and mandibular involvement of BFH is even rarer. The present study reports a case of BFH in a 42-year-old female who had a slowly progressive swelling of the bilateral mandible and slight facial asymmetry over a period of 4 months. However, the outcome of this patient was unsatisfactory, with the first and second recurrence observed 16 and 46 months after surgery, respectively. The present case suggests that BFH has a risk of recurrence after transoral curettage. Regular follow-up is advised to detect tumor recurrence after the surgery of transoral curettage.

show abstract

Benign fibrous histiocytoma: A rare case involving jaw bone

Cited by 9 publications

References 9 publications

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called “Thanatosomes”

Central Xanthoma of the Jaw Bones: A Benign Tumor

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature

Contact Info

Product

Resources

About