Benign Epilepsy of Childhood with Centrotemporal EEG Foci: A Genetic Study

Heijbel, J.; Blom, S; Rasmuson, Marianne

doi:10.1111/j.1528-1157.1975.tb06059.x

Cited by 207 publications

(110 citation statements)

References 17 publications

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“…They start from age 4 to 10 years in 83% of patients and disappear after puberty (32). It is possible to detect fa- milial cases (33), patients that have seizures in clusters (34), or subjects that have only one seizure or spikes in the EEG without seizures (32); male prevalence is 60% in BCECTS (32). Many neurophysiologic characteristics of the fra(X) syndrome-the multifocal paroxysmal activity, its activation during sleep, its age-related appearance, and the presence of spikes in the EEG even without seizures-are similar to those of BCECTS, and both fra(X) and BCECTS are genetically determined conditions.…”

Section: Discussionmentioning

confidence: 99%

Epilepsy and EEG Findings in Males with Fragile X Syndrome

et al. 1999

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Summary: Purpose and Methods: One hundred and ninetytwo fragile X male patients were investigated for seizures and EEG findings, 168 in a retrospective and 24 in another prospective study, to characterize the natural history of seizures, epilepsy, and EEG abnormalities in males with this syndrome.Results: Seizures were documented in 35 (18.2%) of 192 patients; they never started before the age of 2 years or after the age of 9 years. Seizures were frequently of the complex partial type and less frequently of the partial motor and generalized type. Seizures involving frontal and temporal lobes were commonly seen and were usually well controlled by anticonvulsants. I n the majority of young fragile X patients studied, an age-related paroxysmal EEG pattern was found, which showed neurophysiologic characteristics very similar to those of the centrotemporal spikes.Conclusions: These findings confirm that fragile X syndrome can be considered a genetic model of epilepcy.

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Section: Discussionmentioning

confidence: 99%

Epilepsy and EEG Findings in Males with Fragile X Syndrome

et al. 1999

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“…As PRs nem sempre estão associadas à epilepsia [4][5][6][7] ; entretanto são elementos importantes da EPBI-R, cuja fenomenologia tem as seguintes características principais: crises parciais motoras hemifaciais breves, crises parestésicas envolvendo a língua, lábios, gengivas, face interna da bochecha, região lateral da garganta, anartria e hipersalivação 8 . As PRs têm caráter genético bem determinado segundo os estudos dos grupos de Bray e de Degen [9][10][11][12] .…”

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“…A EPBI-R 13 é a epilepsia mais frequente na infância, sendo encontrada entre 13 e 23% de todas crianças epilépticas 11,14 e predomina nos meninos na razão de 60:40 13,15 . Após a descrição das ondas pontas na região temporal média 16 19 , isto é: ritmo de base normal, PR com tendência a forma dipolar com eletropositividade frontal, descargas que ocorreram em salvas, localização, ora num, ora noutro hemisfério cerebral, acentuação e tendência à generalização das descargas durante sono lento e desaparecimento até a adolescência.…”

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Idade de aparecimento e desaparecimento das pontas rolândicas em 160 crianças acompanhadas ambulatorialmente: estudo atuarial

Borges

Godoy

Scarabel

1999

Arq. Neuro-Psiquiatr.

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RESUMO -Proposta: Determinar a idade em que surgem e desaparecem as pontas rolândicas (PR) em traçados eletrencefalográficos de rotina. Método: Estudo prospectivo hospitalar, baseado em 412 eletrencefalogramas de 160 crianças que frequentaram o ambulatório de neuropediatria entre as idades de 1 e 16 anos, no período de março de 1989, a março de 1998. Usou-se o sistema 10/20 para colocação dos eletrodos. As crianças foram dividas, por idade, em quatro grupos (1 a 4; 5 a 8; 9 a 16; 1 a 16) e usou-se o método de curva atuarial, considerandose como evento, o desaparecimento da PR. Resultados: PR teve distribuição entre meninos e meninas na razão de 64/36. A idade média em que surgiu a PR foi 7 anos (7,2 para homens e 6,6 para mulheres) e, num pequeno grupo de crianças que tinha EEG normal anterior ao surgimento da PR, a idade média foi 6,8 anos. Após 7 anos de seguimento, a percentagem de pacientes livres de PRs era 60% para o grupo de 1 a 4 anos na admissão, 84% para os grupos de 5 a 8 anos e 9 a 16 anos. Para o grupo total (1 a 16 anos) a percentagem de livres de PR, após 7 anos de seguimento, foi 78%. Conclusão: O estudo mostra que as PR surgiram, em média, aos 7 anos e têm probabilidade de desaparecimento até 7 anos de seguimento, independetemente da faixa etária de aparecimento. PALAVRAS-CHAVE: ponta rolândica, epilepsia focal benigna da infância com ponta rolândica, curva atuarial.Age of appearence and disappearence of rolandic spikes of 160 children: an actuarial study ABSTRACT: This study aims to determine the age at which the rolandic spikes (RS) appear and disappear in routine EEGs. Method: It has been carried out a hospital based prospective study of 412 EEGs records of 160 children who had been assisted at the neuropediatric out-patient department during the period between March, 1989 and March,1998. Recordings were made on 8-channel instruments and 10/20 system has been to place the electrodes. The children have been divided into 4 groups, according to their age (1 to 4; 5 to 8; 9 to 16; 1 to 16), and the actuarial curve method has been used to show the disappearance of the rolandic spikes. Results: RS distribution between boys and girls has been 64/36 ratio. RS have been found at average age of 7 years (boys, 7.2 and girls, 6.6). In a small group of children with normal EEGs previous to the RS appearance, the average age has been 6.8 years old. After this 7-year follow up period, the percentage of patients free from RSs was 60% for 1 to 4 year old group at admission; 84% for the 5 to 8 year old group and for the 9 to 16 year old group. For the total group (1 to 16 year old), the percentage of those free from RSs after this 7 year follow up period was 78%.Conclusion: This study shows that RSs appear at the average age of 7 years old, and are likely to disappear up to the end of a 7-year follow up period, independently on the appearance age.KEY WORD: rolandic spikes, centrotemporal spikes, benign childhood epilepsy with centrotemporal spike.

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“…Male predominance of benign rolandic seizures (BRS) and BRE has been suggested in clinical series (2). A genetic predisposition has been suggested (3). The EEG in rolandic epilepsy is characteristic and consists of focal spikes and sharp waves in the central and midtemporal regions (4) frequently demonstrating unique field distribution.…”

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confidence: 99%

Rolandic Epilepsy: An Incidence Study in Iceland

et al. 1998

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Summary:Purpose: We wished to determine incidence, clinical features, and prognosis of benign rolandic seizures (BRS) and benign rolandic epilepsy (BRE) in a total population.Methods: Cases were ascertained through review of all EEG records, and diagnosis was verified by review of medical records. Follow-up information regarding seizures and treatment was obtained from parents and treating physicians.Results: In the Icelandic population aged 3-15 years, the incidence of BRS is 6.2 and BRE 4.7 in 100,000. Five years after onset 95% were seizure-free. At last follow-up, all were seizure free and had not been treated with antiepileptic drugs (AEDs) for at least 1 year. Conclusions:Our study demonstrates that BRS is a common entity in children. The prognosis is excellent and treatment is not necessary in all cases. It is important to identify BREBRS correctly and distinguish it from other types of epilepsy.

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Benign Epilepsy of Childhood with Centrotemporal EEG Foci: A Genetic Study

Cited by 207 publications

References 17 publications

Epilepsy and EEG Findings in Males with Fragile X Syndrome

Epilepsy and EEG Findings in Males with Fragile X Syndrome

Idade de aparecimento e desaparecimento das pontas rolândicas em 160 crianças acompanhadas ambulatorialmente: estudo atuarial

Rolandic Epilepsy: An Incidence Study in Iceland

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