Benign enlargement of the subarachnoid space in infancy

Knipe, Henry; Abdelmonem, Heba

doi:10.53347/rid-59619

Cited by 1 publication

(1 citation statement)

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“…The blood vessels can be differentiated from SLYM, being more hypointense and wide solid lines (marked by blue arrows). ( Image source: Case courtesy of Heba Abdelmonem, Radiopaedia.org, rID: 59619, http://creativecommons.org/licenses/by-nc/4.0/ , (Heba, 2018. )]…”

Section: Discussionmentioning

confidence: 99%

Aligning with the predecessors and counterarguments: A systematic review of the anatomical correlates for the newly discovered meningeal layer in the existing literature

Kumar,

Narayan

et al. 2024

Preprint

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A recent study reported the existence of a subarachnoid lymphatic-like membrane (SLYM), an intermediate leptomeningeal layer between the arachnoid and pia mater in mice and human brains, dividing the subarachnoid space (SAS) into two functional compartments. Despite being a macroscopic structure, how it missed detection in previous studies is surprising. We systematically reviewed the published reports in animals and humans to explore whether prior descriptions of this meningeal layer have existed. An electronic search was conducted in PubMed/Medline, EMBASE, Google Scholar, Science Direct, and Web of Science databases using combinations of MeSH terms and keywords with Boolean operators from inception until 31st Dec 2023. We found at least eight studies that provided structural evidence of an intermediate leptomeningeal layer in the brain or spinal cord. However, unequivocal descriptions for this layer all along the central nervous system were scarce. Obscured names were used to describe it, i.e., the epipial layer, intermediate meningeal layer, intermediate lamella, and outer pial layer. Its microscopic/ultrastructural details closely resembled the SLYM. Further, we examined the counterarguments in current literature that are skeptical of this layer's existence. Considering the significant physiological/clinical implications, exploring further structural and functional details of the new meningeal layer is a need of the hour.

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Section: Discussionmentioning

confidence: 99%