Benign endometriosis masquerading as intra-abdominal malignancy: One of the most extreme cases reported and a review of the literature

Abstract

Introduction: To elicit key clinical lessons from an extreme case of endometriosis associated with massive ascites and a review of the literature. Methods: We report one of the most extreme cases of massive ascites caused by endometriosis. For literature review, MEDLINE via OVID (from 1946 to 2016) database was searched. As a result, all the publications based on the keywords relating to the review topic were acquired. Case: A 32-year-old nulliparous woman, with stage 4 endometriosis and primary infertility, presented with massive ascites, complex pelvic mass, pleural effusion, weight loss, anaemia and elevated CA-125 suggesting ovarian malignancy. Six litres of ascites was drained. After extensive investigations to exclude malignancy, endometriosis-related ascites was diagnosed. Red-cell transfusion, nasogastric-tube-feeding and gonadotrophin-releasing-hormone analogue were initiated and longterm follow-up is planned. Ablation of ovarian function either by surgical oophorectomy or ovarian irradiation appears to cure the condition without recurrence. Endocrine therapy, in the form of gonadotrophin-releasing-hormone analogue or progestins, is useful if surgery is undesirable, as most women with this condition are young and wish to preserve fertility. Endocrine therapy alone resolves the problem in the majority, but ascites reappears after stopping treatment. Conclusion: Endometriosis associated with massive ascites and pleural effusion is rare. There are less than 30 similar case reports in the literature. In women of reproductive age who present with clinical and imaging features to suggest ovarian malignancy, a diagnosis of endometriosis should be considered. Although permanent cure is by oophorectomy, endocrine therapy is useful if surgery is undesirable.

Clinical Presentation and Management of Endometriosis-Related Hemorrhagic Ascites: A Case Report and Systematic Review of the Literature

“…The recurrence rate observed at the time of presentation or after initial management was 36.90% (31/84), while that after definitive surgery and/or ovarian function suppression was 8.33% (7/84). Five of these cases reported significant ascites upon the cessation of GnRH therapy [35,49,50,62] or upon shifting from GnRH to progestogen therapy [15]. The other two had reaccumulating minimal ascites while on oral COC [35] or oral progestogen [70].…”