Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation

Cichoń, Natalia; Czarny, Piotr; Bijak, Michał; Miller, Elżbieta; Śliwiński, Tomasz; Szemraj, Janusz; Saluk‐Bijak, Joanna

doi:10.1155/2017/2181942

Cited by 35 publications

(32 citation statements)

References 52 publications

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“…After a four-week rehabilitation program where one group also received ELF-EMF field (40 Hz, 7 mT for 15 min/day for four weeks), ELF-EMF induced a significant improvement in functional (Activities of Daily Living) and mental (Mini-Mental State Examination and Geriatric Depression Scale) status. As well as an increase in antioxidant gene expression, nitric oxide metabolites, oxidative stress, and interleukin-1β were all improved/increased [37][38][39][40][41][42]. Indeed, a neuroprotective role of IL-1β-dependent in the regulation of neurotrophic factors has already been hypothesized [43].…”

Section: Discussionmentioning

confidence: 95%

Pilot Study on the Effect of Biophysical Therapy on Salivary Alpha-Amylase as a Surrogate Measure of Anxiety/Stress: In Search of a Novel Noninvasive Molecular Approach for the Management of Stress

Ferrara

Egan²,

Foletti

2020

IJMS

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Anxiety and depression impact dramatically on public health, underlying the importance of alternative cost-effective treatments. Previous studies have shown that biophysical treatment can significantly reduce anxiety symptoms and recently, salivary alpha-amylase (SAA) has been identified as an objective correlate of the sympathetic-parasympathetic imbalance related to increased stress burden, defined as allostatic load. The aim of this study was to evaluate the effect of biophysical therapy on SAA levels, in addition to the Depression Anxiety Stress Scale (DASS)-21 questionnaire. Twenty-four workers (sales representatives) presenting with mild anxiety/stress symptoms (Generalized Anxiety Disorder 7-item scale of > 5) were randomized to biophysical treatment (N = 12) or placebo control (N = 12). The biophysical group underwent electromagnetic information transfer through an aqueous system procedure, with daily self-administration for one month. SAA collection and the DASS-21 questionnaire were undertaken at baseline and after one month in all patients. Clinical characteristics and baseline DASS-21 subscale scores were similar between placebo and biophysical group at baseline. After one month, patients receiving biophysical therapy had significantly reduced SAA levels compared to the placebo group (27.8 ± 39.4 vs. 116.8 ± 114.9 U/mL, p = 0.019). All three DASS-21 subscales, depression (9.3 ± 5.1 vs. 5.7 ± 5.5, p = 0.1), anxiety (6.7 ± 25 vs. 3.7 ± 2.2, p = 0.0049) and stress (10.8 ± 4.2 vs. 7.3 ± 3.7, p = 0.041) were also decreased after biophysical treatment compared to placebo after one month. Our findings suggest that biophysical therapy can benefit workers with mild (subclinical) anxiety/stress. These results were also validated by the concomitant reduction of SAA levels and an improvement in DASS-21 subscales. The underlying molecular mechanisms of this therapy remain to be characterized.

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Section: Discussionmentioning

confidence: 95%

Pilot Study on the Effect of Biophysical Therapy on Salivary Alpha-Amylase as a Surrogate Measure of Anxiety/Stress: In Search of a Novel Noninvasive Molecular Approach for the Management of Stress

Ferrara

Egan²,

Foletti

2020

IJMS

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“…This fact has no implications on astrocyte culture, but at the nervous system level it could have a potentially effect on neurons. Nitric oxide (NO) is one of the most important signal molecules, involved in both physiological and pathological processes [11]. As a neurotransmitter in the central nervous system, NO regulates cerebral blood flow, neurogenesis, and synaptic plasticity.…”

Section: Fig 2 Standard Nano2 Curvementioning

confidence: 99%

“…As a neurotransmitter in the central nervous system, NO regulates cerebral blood flow, neurogenesis, and synaptic plasticity. Cichon and col. showed that application of extremely low frequency EMF significantly increased 3-nitrotyrosine and nitrate/nitrite levels, while expression of NOS 2 was insignificantly decreased in both groups, with improving in functional and mental status and promoting recovery in poststroke patients [11]. There are also strong evidences about the role of oxidative stress in neurological degeneration and glaucoma [12][13][14][15].…”

Section: Fig 2 Standard Nano2 Curvementioning

confidence: 99%

Neuroprotective Effects of Low Intensity and Low Frequency Electromagnetic �in vitro� Stimulation on Glial Cells

Dascălu¹,

Serban²,

Vladila³

et al. 2020

Rev. Chim.

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Degenerative neurological diseases (senile dementia, Alzheimer's disease, glaucoma), post-stroke sequelae are increasing as prevalence nowadays, in context of aging in general population, and there are strong evidences that astrocytes may play a significant role in neuroprotection. The study evaluates the effects of low intensity low frequency electromagnetic field (EMF) "in vitro" stimulation (195 mA,(7)(8) on the glial cells, in different conditions, in order to identify the neuroprotective potential. Three cell lines were used for the study: the Clonetics (Lonza) line of normal human astrocytes, U87 glioblastoma tumor cells (ATCC) and L929 murine fibroblasts. The cell cultures were exposed to EMF stimulation for 2 hours/day, for 5 and 10 day, in absence and in the presence of oxidative stress stimuli. Cell viability, apoptotic potential, changes in cell phenotype, stimulation of cell proliferation for normal and malignant transformed cell lines, resilience to oxidative stress were investigated. The viability of the cells was investigated by MTS assay, and the Griess test was used to detect nitrite production as a marker of oxidation and inflammation. Inverted microscopy examination revealed that following exposure to the tested EMF, no morphological changes of the cells were recorded. In none of the cell lines tested, no cytotoxic or cytopathic effects were observed in the cultures exposed under low density conditions. In case of exposure of cell cultures for 10 days to the action of EMF, a viability of 98.2% of glial cells and 97% of exposed fibroblasts is observed, compared to unexposed cells. The viability of the cells exposed to both EMF and oxidative and inflammatory stimuli is increased by 0.96% in the case of H2O2 stimulation and in 3.76% in the case of LPS stimulation, suggesting a possible neuroprotective effect of EMF exposure. Low intensity low frequency EMF "in vitro" stimulation increased viability of the glial cells exposed to oxidative and inflammatory stimuli. No cytotoxic or cytopathic effects were observed in the exposed cultures under conditions of low density. Further tests are needed in order to elucidate the mechanisms of action of EMF on astrocytes, especially on astrocyte-neuron co-cultures to highlight the interactions between these cell types. Confirmation of the neuroprotective effect of low intensity and low frequency EMF opens the way for the development of an innovative, non-invasive therapy.

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“…In paper [7], the processes of interaction between electromagnetic radiation, a biological object and a technical system were outlined. A biological object is represented by a homogeneous structure.…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

Analysis of the electromagnetic field of multilayered biological objects for their irradiation in a waveguide system

Popriadukhin

Popova

Kosulina

et al. 2017

EEJET

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Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation

Cited by 35 publications

References 52 publications

Pilot Study on the Effect of Biophysical Therapy on Salivary Alpha-Amylase as a Surrogate Measure of Anxiety/Stress: In Search of a Novel Noninvasive Molecular Approach for the Management of Stress

Pilot Study on the Effect of Biophysical Therapy on Salivary Alpha-Amylase as a Surrogate Measure of Anxiety/Stress: In Search of a Novel Noninvasive Molecular Approach for the Management of Stress

Neuroprotective Effects of Low Intensity and Low Frequency Electromagnetic �in vitro� Stimulation on Glial Cells

Analysis of the electromagnetic field of multilayered biological objects for their irradiation in a waveguide system

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