Benign: Desmoid tumor: musculoaponeurotic fibrosis of the abdominal wall

Extremity and trunk desmoid tumors

“…There is a higher incidence of these tumors, especially on the abdominal wall, during or soon after pregnancy or while taking oral contraceptives. [21][22][23][24][25] There have also been reports of spontaneous regression of desmoids after menopause and after oophorectomy. [25][26][27] In addition, desmoids are associated with an increased number of estrogen receptors and antiestrogen binding sites, albeit lower than that found in breast cancer specimens.…”

“…[21][22][23][24][25] There have also been reports of spontaneous regression of desmoids after menopause and after oophorectomy. [25][26][27] In addition, desmoids are associated with an increased number of estrogen receptors and antiestrogen binding sites, albeit lower than that found in breast cancer specimens. 19,28 Several anecdotal reports have suggested that the use of various antiestrogen agents result in regression of these tumors.…”

Aggressive fibromatosis of the abdominal wall, limbs and limb girdles

“…These patients were treated by radiotherapy (two), chemotherapy (three), antioestrogen therapy (six) or observation (16). One of the patients treated with radiotherapy had a complete response maintained at 45 months of follow-up, and one had a complete response to chemotherapy and remains disease-free after 127 months.…”

Fibrome desmoïde – Transformation en fibrosarcome

“…L'envahissement, toujours loco régional, emporte le malade après de longues années d'évolution. Plusieurs cas de rémissions spontanées ont été signalés [4,7,36], Elles correspondent à des changements physiologiques de l'équilibre hormonal (puberté, méno pause, grossesse).…”

“…Ces constatations expérimentales [3,20], doublées par celles de la cli nique -augmentation de l'incidence chez la femme et en particulier durant l'activité génitale; rémissions spontanées après la ménopause [27] et pendant la grossesse [4] -plaident en faveur d'une hormonodépendance des TD. Ce pendant, la TD que présentait notre patiente en février 1978 ne contenait pas de récepteurs hormonaux ni pour l'oestradiol ni pour la progestérone.…”