Benign dermal Schwannoma with glandular elements-true heterology or a local 'organizer' effect?

Fletcher, Christopher D.�M.; Madziwa, D.; Heyderman, Eadie; McKee, Phillip H.

doi:10.1111/j.1365-2230.1986.tb00495.x

Cited by 31 publications

(15 citation statements)

References 33 publications

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“…It is therefore reasonable to assume that the tumor may have appeared in the nerves around the eccrine glands and grown to the subcutaneous tissue, and that the glands may have been left behind, rather than have been trapped in the expansile tumor. This speculation should be verified by comparison to other benign glandular PNST, 3–6 whose histogenesis is probably similar to the present tumor.…”

Section: Discussionsupporting

confidence: 66%

“…These structures appear in tumors due to epithelial differentiation, therefore, the tumors are generally classed as glandular PNST. Most of these tumors have been reported to be a malignant PNST phenotype, 1 but several authors have described a benign counterpart of glandular PNST, including schwannoma and neurofibroma 1–10 . In this paper we report a case of benign PNST involving glandular structures, and we discuss its histogenesis.…”

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confidence: 88%

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Non‐neoplastic glandular structures in a benign peripheral nerve sheath tumor

Kusumi

Tanaka

Kurita

et al. 2001

Pathology International

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It is a recognized fact that glandular structures sometimes occur in peripheral nerve sheath tumors (PNST). Reports indicate that epithelial potential could be expressed in malignant PNST, while the glands in most benign PNST could be trapped skin adnexa. We present a case of spindle cell tumor with glandular structures. The patient was a 55-year-old man who had a subcutaneous tumor excised. The spindle cell tumor had histological characteristics of neurofibroma. The glandular structures had a pattern of immunohistochemical staining that was similar to that of the secretory coils and excretory ducts of normal eccrine glands. Therefore, the glands were thought to be naturally existing eccrine glands. The glands were completely enclosed within the tumor and not connected to one another; a cluster formation was not observed. The upper portion of tumor included some glands of skin adnexa. The spindle cell tumor may have originated from the nerves distributed around the skin adnexa, and grown to the subcutaneous tissue. The glands may have been left behind rather than have been trapped in the tumor.

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Section: Discussionsupporting

confidence: 66%

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confidence: 88%

Non‐neoplastic glandular structures in a benign peripheral nerve sheath tumor

Kusumi

Tanaka

Kurita

et al. 2001

Pathology International

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“…Yoshida and Toot 1 proposed that glandular schwannomas may be derived from pluripotential neural crest cells, which is currently the most widely accepted hypothesis. 1,4 During ontogeny, neural crest cells differentiate into multiple phenotypes, including melanocytes, the cranial skeleton, virtually all peripheral nervous structures, and supporting elements of the nervous system, such as glia and Schwann cells. The tumours derived from these structures are thought to have the plasticity to differentiate into various elements, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral nerve sheath tumours may show heterologous differentiation, including cartilage, bone and striated muscle, but glandular differentiation is the rarest form 1 . Most reported glandular schwannomas have been malignant, while benign glandular schwannoma is quite rare; only seven cases have been reported in the literature 1–7 . Glandular schwannomas have been described on the trunk or extremities, but there have been no previous reports describing scalp involvement.…”

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confidence: 99%

Benign glandular schwannoma

et al. 2001

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Glandular schwannoma is a rare variant of schwannoma characterized by the presence of glands in an otherwise typical schwannoma. We report a patient with benign glandular schwannoma occurring on the scalp, a site not previously reported. Histologically, a well-defined, encapsulated oval nodule was observed in the subcutaneous tissue. The nodule was composed of a spindle cell component and glandular structures. The spindle cell component stained positively for S-100 protein. All of the glandular epithelium stained with CAM 5.2 and epithelial membrane antigen but not with S-100 protein. The glandular epithelium was focally positive for carcinoembryonic antigen. The histogenesis of the glandular elements in these tumours is still debated. The variable size of the glandular structures in our case was evidence against an entrapped normal sweat gland origin. The glandular epithelium did not stain with S-100 protein at all, but stained with CAM 5.2, which did not support a direct metaplastic origin of the epithelial elements from the schwannian component. A few scattered CAM 5.2-positive cells and microglandular structures in our case may be the initial differentiating epithelial elements possibly derived from pluripotential neural crest cells.

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“…There has been no prior report describing parotid involvement. This is a still poorly recognized variant which at first glance, may be misconstrued as a glandular schwannoma (5, 6). The pseudoepithelial lining reportedly exhibited no reactivity for cytokeratin and epithelial membrane antigen in the presence of schwann cell‐related markers (1–4), a finding confirmed by the present study.…”

Section: Commentsmentioning

confidence: 99%

Intraparotid pseudoglandular schwannoma

Ide

Obara

Mishima

2006

J Oral Pathology Medicine

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A unique intraparotid location of a rare pseudoglandular schwannoma is described. Although the diagnosis of schwannoma could readily be substantiated, accurate subtyping was initially mislabeled. The pitfall was in failing to acknowledge the presence of multiple well-formed gland-like structures, which is instantly thought to be cystically dilated salivary ducts. Immunohistochemically, epithelial-appearing cells lining the duct-like spaces proved to be schwannian in nature. Interpretation of an immediately recognizable gland-like architecture is more problematic when a pseudoglandular variant originates from a nerve coursing through the gland, as here.

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Benign dermal Schwannoma with glandular elements-true heterology or a local 'organizer' effect?

Cited by 31 publications

References 33 publications

Non‐neoplastic glandular structures in a benign peripheral nerve sheath tumor

Non‐neoplastic glandular structures in a benign peripheral nerve sheath tumor

Benign glandular schwannoma

Intraparotid pseudoglandular schwannoma

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