BENIGN CLEAR CELL TUMOR OF THE LUNG A Histopathologic Study

Clear cell tumors of the lung are rare tumors composed of epithelioid HMB45 positive tumor cells. It has been proposed that clear cell tumors generate from perivascular epithelioid cells which are also found in renal angiomyolipoma. Due to its morphologic epithelioid features with clear cytoplasm the distinction from either primary or metastatic clear cell carcinoma is difficult. Usually clinical investigations do not lead to the final diagnosis so that only subsequent histological examination and immunophenotyping can establish the correct tumor classification. We describe the case of a 52 year old woman who underwent exploratory thoracotomy because of a lung mass in the right lower lobe. In frozen sections a solid trabecular tumor was diagnosed, paraffin histology and immunohistochemistry revealed a clear cell tumor of the lung. The difficulty of the correct diagnosis of the clear cell tumor of the lung in frozen sections is discussed as well as the differential diagnosis.

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Klarzelltumor der Lunge

Drebber

Ortmann

Kasper

et al. 2005

Pathologe

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Benign clear cell tumor of the lung; a case report.

et al. 1993

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Malignant lung PEComa (clear cell tumor): rare case report and literature review

Campos,

Vasques,

Medeiros

et al. 2023

Front. Oncol.

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Clear cell tumors of the lung (CCTL), or “sugar tumors” of lung, are very uncommon lesions and are mostly benign perivascular epithelioid cell (PEC) tumors with no specific morphologic features. Fewer than 100 cases have been reported; the aggressive nature demonstrated in sporadic reports has rarely been described in the literature. Although the course is generally described as benign, eight reported cases showed malignant behavior. We report a case of a PEC with a malignant presentation in a young man, correlating the main characteristics of the tumor with other cases reported in the literature to better elucidate this rare presentation. We also performed a literature review of reports on benign and malignant CCTL cases, with a focus on clinical, imaging, and immunohistochemical differentiation. CCTLs are rare tumors that require histopathological and immunohistochemical confirmation; to date, criteria that can predict malignant evolution are lacking.

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BENIGN CLEAR CELL TUMOR OF THE LUNG A Histopathologic Study

Cited by 4 publications

References 12 publications

Klarzelltumor der Lunge

Klarzelltumor der Lunge

Benign clear cell tumor of the lung; a case report.

Malignant lung PEComa (clear cell tumor): rare case report and literature review

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