Benign chondroid syringoma of foot: a clinical dilemma

Abstract

Chondroid syringoma is a rare skin appendageal tumor which is most commonly encountered in the head and neck region. We herein report an unusual case of a benign chondroid syringoma of the left foot in a 40-year-old female which posed as a diagnostic conundrum. The approach to such a case, differential diagnosis and the management of this rare entity is also presented.

Chondroid Syringoma with Extensive Cartilaginous Differentiation

“…Chondroid syringoma is rare, benign skin appendegeal tumor representing 0.01%–0.098% of primary skin tumors. [ 1 2 ] Common locations are head and neck, yet extremities, chest, abdomen, and genital area have been reported. [ 1 2 3 4 ] Usually affects middle-aged men presenting as firm, painless, well-demarcated tumor.…”

“…[ 1 2 ] Common locations are head and neck, yet extremities, chest, abdomen, and genital area have been reported. [ 1 2 3 4 ] Usually affects middle-aged men presenting as firm, painless, well-demarcated tumor. [ 1 2 ] Characteristic appearance of both components (epithelial, mesenchymal) within chondromyxoid stroma can be accompanied by skin adnexal structures (hair follicles, sebaceous glands, and apocrine glands), osseous tissue, and cartilage.…”

“…[ 1 2 3 4 ] Usually affects middle-aged men presenting as firm, painless, well-demarcated tumor. [ 1 2 ] Characteristic appearance of both components (epithelial, mesenchymal) within chondromyxoid stroma can be accompanied by skin adnexal structures (hair follicles, sebaceous glands, and apocrine glands), osseous tissue, and cartilage. [ 1 ] To the best of our knowledge, few cases demonstrating large amount of cartilage have so far been reported.…”

“…[ 1 2 ] Characteristic appearance of both components (epithelial, mesenchymal) within chondromyxoid stroma can be accompanied by skin adnexal structures (hair follicles, sebaceous glands, and apocrine glands), osseous tissue, and cartilage. [ 1 ] To the best of our knowledge, few cases demonstrating large amount of cartilage have so far been reported. [ 4 5 ] This feature recognition is important to avoid possible diagnostic pitfalls and provide adequate treatment and follow-up.…”

“…This tumor is characterized by both epithelial elements demonstrating apocrine or eccrine differentiation and mesenchymal component comprised of myxoid or collagenous matrix. [ 1 ] Dermoscopic pattern is nonspecific, undefined, and insufficient for the diagnosis;[ 3 ] thus, the diagnosis is obtained through pathohistological analysis according to the presence of one or combination of cuboidal or polygonal cells nests, tubuloalveolar structures, keratinous cysts, matrix (myxoid, chondroid, adipocytic, fibrous), and ductal structures with one or two rows of cuboidal cells. [ 1 2 5 ] Initially, fine needle aspiration (FNA) cytology can be performed revealing chondromyxoid matrix containing uniform plasmacytoid and epithelial cells.…”