Benign cholestatic jaundice of pregnancy and benign cholestatic jaundice from oral contraceptives

Drill, Victor A.

doi:10.1016/0002-9378(74)90029-5

Cited by 50 publications

(14 citation statements)

References 35 publications

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“…However, apparently mice are much less susceptible to the hepatotoxic effects of tetracyclines and ethinyl estradiol than humans. Signs of deterioration of liver function similar to those observed in our experiments are frequently observed in women treated with the lower doses of ethinyl estradiol used in clinical practice [12,18,21,22,29].…”

Section: Drugssupporting

confidence: 62%

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice

et al. 1985

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The combined effects of ethinyl estradiol (EE) (0.5 micrograms/g s.c. once daily for 4 days) and tetracycline (TC) or doxycycline (DC) (50 micrograms/g i.v.) on liver weight and water content, serum transaminases, alkaline phosphatase, urea, triglycerides, and cholesterol as parameters of various liver functions were investigated in mice. It became apparent that depending on the parameter tested synergistic and antagonistic effects may occur, e.g., synergistic effects were observed with the serum transaminases and liver cholesterol; antagonistic effects were seen with the serum urea and serum cholesterol.

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Section: Drugssupporting

confidence: 62%

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice

et al. 1985

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“…Indeed the multiple pregcould be caused by a concomitant urinary tract infection. 1 ICP with jaundice but without pruritus is rare 18 and we ob-nancy rate in our series was much higher than that generally observed in France (1%). This is not surprising because it served only one case.…”

Section: Progesterone Intake In Control Population Of Pregnant Womencontrasting

confidence: 45%

Intrahepatic cholestasis of pregnancy: A French prospective study

et al. 1997

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The prevalence of ICP varies greatly according to country. The aim of this prospective study was to analyze the charac-The prevalence is high in Scandinavian countries (1%-teristics of intrahepatic cholestasis of pregnancy (ICP) in a 1.5%), 3,4 in Bolivia (9.2%), 5 and in Chile, with a prevalence French population. From 1989 to 1995 we studied 50 consecof between 11.8% and 27.6% according to ethnic origin. 6 In utive pregnant women with ICP (41 single, 7 twin, and 2Santiago the prevalence of ICP was recently evaluated at 4%. 7 triplet pregnancies) referred for hepatologic consultation. All In contrast, the prevalence is reported to be low in the United patients suffered from pruritus and/or jaundice associated States, 8 Canada, 9 and Switzerland. 10 In France the prevalence with elevated fasting serum levels of total bile acids (mean has been assessed to be 0.2% to 0.5% 11,12 and ICP has not 49 mmol/L, range 7-290). No patients had concomitant liver often been studied. disease and all recovered normal liver function after delivery.The aim of this prospective study was to analyze characterOverall prematurity rate was 60%: 100% in multiple pregnanistics of ICP in France. rently treated with cholestyramine), after decrease in dose ofSigns of pre-eclampsia, fever, and urinary or endocervical infection progesterone in 1 patient, and spontaneously in 2 patients.were exclusion criteria. In cases of recurrent ICP the first occurrence During the same period, the percentage of pregnant women during the period under study was taken into account for the dewithout ICP who had been treated with progesterone during scription of characteristics. pregnancy was statistically lower than the percentage of patients treated with progesterone before the onset of pruritus Methods in our group of patients with ICP (36% vs. 64%, P õ .01, Biological Tests. Fasting blood samples were taken and serum TBA odds ratio 3.16, 95% CI:1.29-7.80). These results suggest that and total bilirubin and conjugated bilirubin concentrations, and orally administered progesterone might be an exogenous fac-serum ALT, alkaline phosphatase (AP), and g-glutamyl transpeptitor which triggers ICP in predisposed women. (HEPATOLOGY dase (GGT) activity, were measured at least twice, for each patient. 1997;26:358-364.)In fact, this was usually once or twice a week until delivery. Serum aspartate aminotransferase (AST) and 5 nucleotidase activity was measured in 19 and 44 patients, respectively. Prothrombin time, Intrahepatic cholestasis of pregnancy (ICP) is a liver discreatininemia, and uricemia were also regularly monitored. For each ease unique to pregnancy, which occurs in the second or patient, the most abnormal values, i.e., the highest values for LFTs, third trimesters and disappears spontaneously after delivery. uricemia, creatininemia, and the lowest values for prothrombin timeThe occurrence of ICP carries a risk for the fetus and pruritus were retained for the calculation of the biological characteristics. is a very uncomfortable symptom for the mother. ...

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“…Le rôle des estrogènes est prépondérant. Il est bien connu que l'administration d'ethnyl estradiol ou parfois la prise d'estroprogestatifs à visée contraceptive chez des patientes aux antécédents de cholestase intrahépatique gravidique peut reproduire les signes de la cholestase [5]. Le métabolisme de la progestérone est également impliqué.…”

Section: Facteurs Hormonauxunclassified

La cholestase intrahépatique gravidique

Sentilhes

Bacq

2008

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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Benign cholestatic jaundice of pregnancy and benign cholestatic jaundice from oral contraceptives

Cited by 50 publications

References 35 publications

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice

Intrahepatic cholestasis of pregnancy: A French prospective study

La cholestase intrahépatique gravidique

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