Benign Childhood Focal Seizures and Related Epileptic Syndromes

Panayiotopoulos, C. P.

doi:10.1007/978-1-84996-477-7

Cited by 36 publications

(125 citation statements)

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“…The combined rates of the severe types is similar to the 7% previously reported by Fejerman et al. (2000) and significantly higher than the 1% reported by Panayiotopoulos (1999). The rate of frequent refractory seizures accounting for 1.5% is much lower than the reported 6–18% prevalence (Lerman & Kivity, 1975; Loiseau et al., 1988; Kramer et al., 2002).…”

Section: Discussionsupporting

confidence: 72%

“…The current consensus is that atypical forms of BCECTS are actually common, but there are different views regarding their frequency. The frequency is as low as 1–7% if only patients with Landau‐Kleffner syndrome, electrical status epilepticus in slow wave sleep (ESES), and classic atypical BCECTS are considered (Panayiotopoulos, 1999; Fejerman et al., 2000). When less strict criteria are applied, however, the frequency varies substantially among different studies and ranges between 9% and 52% (Beaussart & Faou, 1978; Morooka et al., 1995; Wirrell et al., 1995; Massa et al., 2001; Verrotti et al., 2002; Datta & Sinclair, 2007).…”

Section: Atypical Formsmentioning

confidence: 99%

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The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes

et al. 2011

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Summary Purpose: Benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most common epileptic syndrome in childhood. The outcome is usually excellent, but there are some atypical forms of BCECTS with less favorable outcomes. The aim of this study was to delineate the frequency of these atypical features among patients with BCECTS. Methods: We conducted a retrospective chart study by retrieving the medical records of all consecutive patients with BCECTS who were evaluated in four pediatric neurology outpatient clinics in Israel between the years 1991 and 2008. Key Findings: A total of 196 patients with BCECTS were identified (78 female and 118 male; mean age at time of diagnosis 7.64 years, range 1.5–14). The mean duration of follow‐up was 4.43 years (range 2–11). Nine patients (4.6%) developed electrical status epilepticus in slow waves sleep (ESES) during follow‐up, four (2%) had Landau‐Kleffner syndrome, three (1.5%) had BCECTS with frequent refractory seizures, two (1%) had BCECTS with falls at presentation, one (0.5%) had a “classic” atypical variant, and one (0.5%) had oromotor dysfunction. None had rolandic status epilepticus. Sixty‐one patients (31%) had attention deficit hyperactivity disorder (ADHD), 43 (21.9%) had specific cognitive deficits, and 23 (11.7%) had behavioral abnormalities, including aggressiveness, anxiety disorders, depression, and pervasive developmental disorder (PDD). Significance: The prevalence of most atypical forms of BCECTS other than ESES is low. There is, however, a high prevalence of ADHD and specific cognitive deficits among patients with BCECTS.

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Section: Discussionsupporting

confidence: 72%

Section: Atypical Formsmentioning

confidence: 99%

The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes

et al. 2011

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“…In a number of the benign childhood focal epilepsies (the main forms of which are benign childhood epilepsy with centrotemporal (Rolandic) spikes, early-onset benign childhood occipital epilepsy (Panayiotopoulos syndrome) and late onset childhood occipital epilepsy of Gastaut), seizures occur exclusively or mainly during sleep 20. The same is true of nocturnal frontal lobe epilepsy (NFLE) mainly seen in adults but also described in young patients 21…”

Section: Diagnostic Confusions Between Sleep Disorders and Epilepsymentioning

confidence: 99%

Sleep disturbance in childhood epilepsy: clinical implications, assessment and treatment

Stores

2013

Archives of Disease in Childhood

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The ways in which sleep can affect epilepsy, and epilepsy can influence sleep and wakefulness, are described. Different forms of sleep disturbance have been reported in patients with epilepsy, depending on the type of seizure disorder. Confusions between epilepsy and non-epileptic parasomnias can be a particular diagnostic problem but they can be avoided. Untreated sleep disturbance is likely to have harmful psychological, physical and family effects. Screening for sleep disturbance should be routine, and leading, if indicated, to precise diagnosis of the underlying sleep disorder on which choice of advice and treatment depends.

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“…BECTS is characterized by a typical interictal pattern on EEG: very frequent high-voltage centro-temporal spikes (CTS) typically activated by sleep. The prognosis for seizure outcome in BECTS is excellent; most patients have less than 10 seizures, and seizure activity is expected to cease by adulthood (Blom & Heijbel, 1982; Camfield & Camfield, 2002; Dalla Bernardina, Sgro, & Fejerman, 1995; Loiseau, Duche, Cordova, Dartigues, & Cohadon, 1988; Panayiotopoulos, 1999). However, a growing body of literature has documented subtle cognitive and/or behavioral problems in children with BECTS, particularly affecting language function (Baglietto et al, 2001; Danielsson & Petermann, 2009; Ebus, Overvliet, Arends, & Aldenkamp, 2011; Goldberg-Stern et al, 2010; Jurkeviciene et al, 2012; Northcott et al, 2005; Overvliet, Aldenkamp, Klinkenberg, Nicolai, et al, 2011; Overvliet, Besseling, van der Kruijs, et al, 2013; Overvliet, Besseling, et al, 2011; Samaitiene, Norkuniene, Jurkeviciene, & Grikiniene, 2012; Samaitiene, Norkuniene, Tumiene, & Grikiniene, 2013; Verrotti, Filippini, Matricardi, Agostinelli, & Gobbi, 2014; Volkl-Kernstock, Bauch-Prater, Ponocny-Seliger, & Feucht, 2009).…”

Section: Introductionmentioning

confidence: 99%

Changes in functional organization and functional connectivity during story listening in children with benign childhood epilepsy with centro-temporal spikes

et al. 2019

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Children with Benign Epilepsy with Centrotemporal Spikes (BECTS), despite high likelihood for seizure remission, are reported to have subtle difficulties in language and other cognitive skills. We used functional MRI and a story listening task to examine the effect of BECTS on patterns of activation and connectivity. Language and cognitive skills were assessed using standardized measures. Twenty-four children with recently diagnosed BECTS and 40 typically-developing children participated. In a functionally-defined region of interest in right inferior frontal gyrus, BECTS patients showed a lower level of activation. Across both groups combined, increased activation in superior/middle temporal regions of interest was associated with better language scores. Connectivity in the story processing network was similar between groups, but connectivity within left inferior frontal gyrus was decreased in children with BECTS. These results suggest that language networks are largely maintained in new-onset BECTS, but some subtle changes in activation and connectivity can be observed.

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Benign Childhood Focal Seizures and Related Epileptic Syndromes

Cited by 36 publications

References 0 publications

The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes

The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes

Sleep disturbance in childhood epilepsy: clinical implications, assessment and treatment

Changes in functional organization and functional connectivity during story listening in children with benign childhood epilepsy with centro-temporal spikes

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