Benign Cervical Leiomyoma Leading to Disseminated Fatal Malignancy

O’Connell, Michael P.; Jenkins, David; Curtain, Andrew; Hughes, Paul A.; Doyle, Joseph T.

doi:10.1006/gyno.1996.0200

Cited by 7 publications

(3 citation statements)

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“…Loss of this intracellular control of viral gene expression permits the expression of viral oncogenes. Due to their inhibition of various cellular cell cycle regulators this results in a significant reduction of control functions of the G1/Sphase transition in the cell cycle, presumably allowing cells to enter the S-phase without prior proof-reading of their genomes and thus accumulation of mutations in the respective daughter cells [18][19][20]. Enhanced expression of the viral oncogenes is directly linked to the cell kinetics of HR-HPV transformed cells and reduction of the activity of the viral oncogenes, results in reduced cell growth and loss of the neoplastic properties of cervical cancer cells [21][22][23].…”

Section: Expression Of the Hr-hpv Oncogenes E6-e7 Is Required To Indumentioning

confidence: 99%

New Molecular Tools for Efficient Screening of Cervical Cancer

Doeberitz

2001

Disease Markers

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Cytological screening using the Pap-smear led to a remarkable reduction of the mortality of cervical cancer. However, due to subjective test criteria it is hampered by poor inter- and intra-observer agreement. More reproducible assays are expected to improve the current screening and avoid unnecessary medical intervention and psychological distress for the affected women. Cervical cancer arises as consequence of persistent high risk papillomavirus (HR-HPV) infections. Expression of two viral oncogenes, E6 and E7, in epithelial stem cells is required to initiate and maintain cervical carcinogenesis and results in significant overexpression of the cellular p16INK4a protein. Since this protein is not expressed in normal cervical squamous epithelia, screening for p16INK4a over-expressing cells allows to specifically identify dysplastic lesions, and significantly reduces the inter-observer disagreement of the conventional cytological or histological tests. Progression of preneoplastic lesions to invasive cancers is associated with extensive recombination of viral and cellular genomes which can be monitored by detection of papillomavirus oncogene transcripts (APOT assay) derived from integrated viral genome copies. Detection of integrated type oncogene transcripts points to far advanced dysplasia or invasive cancers and thus represents a progression marker for cervical lesions. These new assays discussed here will help to improve current limitations in cervical cancer screening, diagnosis, and therapy control.

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Section: Expression Of the Hr-hpv Oncogenes E6-e7 Is Required To Indumentioning

confidence: 99%

New Molecular Tools for Efficient Screening of Cervical Cancer

Doeberitz

2001

Disease Markers

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“…The current approach is to simply extrapolate diagnostic criteria from the corpus tumours and apply them to their cervical counterparts, incorporating various combinations of cytologic atypia, coagulative necrosis and mitotic activity to predict their malignant potential [11]. However, it is unclear if this is entirely appropriate in all cases [12].…”

Section: Discussionmentioning

confidence: 98%

Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature

et al. 2012

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Background : Epithelioid leiomyosarcoma arising from the uterine cervix is extremely rare, with only few cases reported in the world literature Case presentation : The case concerns a 41-year-old female patient who was admitted to our hospital, with worsening menorrhagia during the past 6 months. Pelvic examination revealed a large tumour of the uterine cervix extended into the upper vagina. Pelvic magnetic resonance imaging confirmed the presence of a cervical uterine tumour. Cervical biopsy and immunohistological study concluded leiomyosarcoma (grade 2). Radiological workup revealed the presence of pulmonary metastasis. A bilateral nephrostomy was performed before treatment because of obstructive renal failure. The treatment of this case consisted of ifosfamide and doxorubicin-based chemotherapy. After three cycles, the assessment of the disease showed partial response. The treatment was continued for three other cycles. But, the second evaluation of the patient revealed tumour progression. The treatment was then stopped, and best supportive care was provided. The patient is still alive. Conclusion : Although exceedingly rare, leiomyosarcoma can arise on the uterine cervix. Management of cervical leiomyosarcoma is extrapolated from the currently accepted management of uterine leiomyosarcoma. It is difficult to develop optimal management strategies and to predict prognosis of the disease. Pour citer cette revue : J. Afr. Cancer 4 (2012).Keywords Leiomyosarcoma · Uterine cervix · Chemotherapy · Cervical biopsy Résumé Introduction: Le léiomyosarcome épithélioïde du col utérin est une tumeur extrêmement rare, avec seulement quelques cas rapportés dans la littérature mondiale. Cas clinique: Il s'agit d'une patiente de 41 ans admise dans notre hôpital pour métrorragies datant de six mois. L'examen gynécologique a retrouvé une grosse tumeur du col utérin étendue à la partie supérieure du vagin. L'imagerie par réso-nance magnétique a confirmé la présence d'une tumeur du col utérin. La biopsie cervicale avec étude immunohistochimique a conclu : un léiomyosarcome (grade 2). Le bilan d'extension radiologique a révélé la présence de métastases pulmonaires. Une néphrostomie bilatérale a été réalisée avant le traitement en raison d'une insuffisance rénale obstructive. Le traitement de ce cas consistait en une chimiothérapie à base d'ifosfamide et de doxorubicine. Après trois cycles, l'évaluation de la maladie a montré une réponse partielle. Le traitement a été poursuivi pendant trois autres cycles. Mais, la seconde évaluation de la patiente a révélé une progression tumorale. Le traitement a été arrêté et la malade a été confiée aux soins palliatifs. La patiente est actuellement toujours en vie. Conclusion: Bien que très rare, un léiomyosarcome peut survenir au niveau du col utérin. Le traitement du léiomyosar-come du col utérin est extrapolé sur le traitement du léiomyo-sarcome du corps utérin. Il est difficile d'élaborer des stratégies thérapeutiques optimales et de prédire le pronostic de la maladie.

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“…The current approach is to simply extrapolate diagnostic criteria from the corpus tumors and apply them to their cervical counterparts, incorporating various combinations of cytologic atypia, coagulative necrosis and mitotic activity to predict their malignant potential [ 4 ]. However, it is unclear if this is entirely appropriate in all cases [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Untitled

Fadare

2006

Diagn Pathol

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Sarcomas constitute less than 1% of all cervical malignancies. With over 150 reported cases, rhabdomyosarcomas represent the most commonly reported sarcoma at this location. In this report, a select group of the more uncommon sarcomas of the uterine cervix are reviewed, including all previously reported examples of leiomyosarcoma, liposarcoma, alveolar soft part sarcoma, Ewing sarcoma/primitive neuroectodermal tumor, undifferentiated endocervical sarcoma, and malignant peripheral nerve sheath tumor (MPNST). Emphasis is placed on any distinctive clinicopathologic features of these entities at this unusual location.

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Benign Cervical Leiomyoma Leading to Disseminated Fatal Malignancy

Cited by 7 publications

References 0 publications

New Molecular Tools for Efficient Screening of Cervical Cancer

New Molecular Tools for Efficient Screening of Cervical Cancer

Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature

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