1974
DOI: 10.1136/jnnp.37.12.1322
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Benign aqueduct stenosis in adults

Abstract: SYNOPSIS A series of 55 cases is described in which hydrocephalus associated with non-neoplastic narrowing of the Sylvian aqueduct produced symptoms for the first time in adult life. The clinical features of the patients and their investigation are described and discussed.

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Cited by 57 publications
(27 citation statements)
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“…Earlier similar clinical conditions were termed LIAS (3,5,16,22,53) or simply aqueductal stenosis in adults (32,54). The latter involved only the time of the clinical onset and the cause of hydrocephalus (nontumoral aqueductal stenosis).…”
Section: What Is Lova?mentioning
confidence: 96%
See 1 more Smart Citation
“…Earlier similar clinical conditions were termed LIAS (3,5,16,22,53) or simply aqueductal stenosis in adults (32,54). The latter involved only the time of the clinical onset and the cause of hydrocephalus (nontumoral aqueductal stenosis).…”
Section: What Is Lova?mentioning
confidence: 96%
“…Late-onset idiopathic aqueductal stenosis (LIAS) should be distinguished from the infantile form of aqueductal stenosis because the ability to absorb cerebrospinal fluid (CSF) is different (27). There are several studies of LIAS (3,5,22,32,53), but the majority of reports are from the era before magnetic resonance imaging (MRI).…”
mentioning
confidence: 98%
“…1 Patients with late-onset AS present with various clinical and radiologic features. [1][2][3] New theories have emerged about the pathogenesis of AS in adults, and venous hypertension has been suggested as the primary phenomenon responsible for ventricle dilation and aqueductal obstruction. 4 As a consequence, the determination of the underlying mechanism in hydrocephalus is relevant due to surgical implications because endoscopic third ventriculostomy (ETV) is mainly successful in obstructive hydrocephalus.…”
mentioning
confidence: 99%
“…Clinically they confirmed previous experiences that when nontumoural aqueduct stenosis decompensates in the elderly it usually does so in a normal pressure hydrocephalus fashion. 12 In non-tumoural aqueduct stenosis, one of the contributing factors may be the following: it has been illustrated pathologically that in all forms of chronic hydrocephalus there is severe ependymal disruption and secondary subependymal gliotic reaction. 2938 We speculate that in some of our cases an increasingly narrowed aqueduct by ependymal granulation3940 may have finally led to functionally aqueduct incompetence.…”
Section: Resultsmentioning
confidence: 99%