Bengalin initiates autophagic cell death through ERK–MAPK pathway following suppression of apoptosis in human leukemic U937 cells

Gupta, Sanchita; Halder, Babli; Gomes, Antony

doi:10.1016/j.lfs.2013.06.022

Cited by 15 publications

(7 citation statements)

References 28 publications

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“…Later, a high molecular weight protein (72 kDa) was identified, named bengalin, which has the anticancer activity against the human leukemic cell lines through induction of apoptosis, predominantly mediated by the mitochondrial pathway with the participation of pro and antiapoptotic proteins, and with no significant death of normal human lymphocytes . A more recent work showed cell death induced by bengalin can occur by an alternate pathway other than apoptosis that could be autophagic in nature (Das Gupta et al, 2013). Bengalin also presents anti-osteoporosis activity by its capacity of restoring bone minerals, and cardiotoxicity and neurotoxicity as demonstrated in in vivo experiments (Haldar et al, 2010).…”

Section: Anticancer Peptidesmentioning

confidence: 99%

Scorpion venom components as potential candidates for drug development

Ortíz

Gurrola

Schwartz

et al. 2015

Toxicon

257

203

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Scorpions are well known for their dangerous stings that can result in severe consequences for human beings, including death. Neurotoxins present in their venoms are responsible for their toxicity. Due to their medical relevance, toxins have been the driving force in the scorpion natural compounds research field. On the other hand, for thousands of years, scorpions and their venoms have been applied in traditional medicine, mainly in Asia and Africa. With the remarkable growth in the number of characterized scorpion venom components, several drug candidates have been found with the potential to tackle many of the emerging global medical threats. Scorpions have become a valuable source of biologically active molecules, from novel antibiotics to potential anticancer therapeutics. Other venom components have drawn attention as useful scaffolds for the development of drugs. This review summarizes the most promising candidates for drug development that have been isolated from scorpion venoms.

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Section: Anticancer Peptidesmentioning

confidence: 99%

Scorpion venom components as potential candidates for drug development

Ortíz

Gurrola

Schwartz

et al. 2015

Toxicon

257

203

View full text Add to dashboard Cite

show abstract

“…Bengalin, a 72.0 kDa peptide isolated from the venom of Indian black scorpion Heterometrus bengalensis Koch [ 148 ], is known to have a particular anti-proliferative effect in human leukemic U937 cells [ 149 ]. Treatment of bengalin to U937 cells induced upregulation of ERK 1/2 expression and downregulation of AKT thereby inducing apoptosis.…”

Section: Anti-cancer Mechanism Of Venom Peptidesmentioning

confidence: 99%

“…Bengalin induced caspase-3 activation is observed to induce apoptosis. Bengalin treatment was specific to MAPK ERK 1/2 and did not alter JNK or p38 [ 149 ]. Further, inhibiting ERK 1/2 and caspase 3 using blockers before bengalin treatment lead to activation of autophagy pathway in U937 cells.…”

Section: Anti-cancer Mechanism Of Venom Peptidesmentioning

confidence: 99%

Venom-based peptide therapy: insights into anti-cancer mechanism

Mahadevappa

Kwok

2017

Oncotarget

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The 5-year relative survival rate of all types of cancer has increased significantly over the past three decades partly due to the targeted therapy. However, still there are many targeted therapy drugs could play a role only in a portion of cancer patients with specific molecular alternation. It is necessary to continue to develop new biological agents which could be used alone and/or in combination with current FDA approved drugs to treat complex cancer diseases. Venom-based drugs have been used for hundreds of years in human history. Nevertheless, the venom-origin of the anti-cancer drug do rarely appear in the pharmaceutical market; and this is due to the fact that the mechanism of action for a large number of the venom drug such as venom-based peptide is not clearly understood. In this review, we focus on discussing some identified venom-based peptides and their anti-cancer mechanisms including the blockade of cancer cell proliferation, invasion, angiogenesis, and metastasis (hallmarks of cancer) to fulfill the gap which is hindering their use in cancer therapy. Furthermore, it also highlights the importance of immunotherapy based on venom peptide. Overall, this review provides readers for further understanding the mechanism of venom peptide and elaborates on the need to explore peptide-based therapeutic strategies.

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“…The calcium-activated potassium channel (BKca-channel) blockers, 'Iberiotoxin' (IbTx) and 'Charybdotoxin' (ChTx) were also reported to inhibit the proliferation and migration of glioma 72 and melanoma cells 73 , respectively. Furthermore, anticancer effects of Heterometrus bengalensis venom and its purified substance 'Bengalin' were reported to decrease cancer cell proliferation and enhance apoptosis in leukemic cell lines 74 by the activation of caspase-9, caspase-3 and induced poly (ADP-ribose) polymerase (PARP) cleavage 75 .…”

Section: Scorpion Venoms Including Purified or Synthetic Toxins From mentioning

confidence: 99%

Effects of Animal Venoms and Toxins on Hallmarks of Cancer

Chaisakul¹,

Hodgson²,

Kuruppu³

et al. 2016

J. Cancer

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Animal venoms are a cocktail of proteins and peptides, targeting vital physiological processes. Venoms have evolved to assist in the capture and digestion of prey. Key venom components often include neurotoxins, myotoxins, cardiotoxins, hematoxins and catalytic enzymes. The pharmacological activities of venom components have been investigated as a source of potential therapeutic agents. Interestingly, a number of animal toxins display profound anticancer effects. These include toxins purified from snake, bee and scorpion venoms effecting cancer cell proliferation, migration, invasion, apoptotic activity and neovascularization. Indeed, the mechanism behind the anticancer effect of certain toxins is similar to that of agents currently used in chemotherapy. For example, Lebein is a snake venom disintegrin which generates anti-angiogenic effects by inhibiting vascular endothelial growth factors (VEGF). In this review article, we highlight the biological activities of animal toxins on the multiple steps of tumour formation or hallmarks of cancer. We also discuss recent progress in the discovery of lead compounds for anticancer drug development from venom components.

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Bengalin initiates autophagic cell death through ERK–MAPK pathway following suppression of apoptosis in human leukemic U937 cells

Cited by 15 publications

References 28 publications

Scorpion venom components as potential candidates for drug development

Scorpion venom components as potential candidates for drug development

Venom-based peptide therapy: insights into anti-cancer mechanism

Effects of Animal Venoms and Toxins on Hallmarks of Cancer

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