Benefits versus risks of proton pump inhibitors: are we opening the can of worms

Tadvi, Naser Ashraf; Hussain, Sajid; Ghaffar, Usama Bin

doi:10.5958/2319-5886.2016.00018.7

Cited by 1 publication

(2 citation statements)

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“…Esomeprazole was prescribed for only 16.5%, and a minimum of 2% of patients were prescribed with Rabeprazole. These results were similar to the study conducted by Nousheen et al ( 2013) 2 , where it was reported that pantoprazole was the most commonly prescribed drug. As shown in Table 2, a maximum of 71.5% of the 200 patients were given an injection, 24% were given a tablet, and 4.5% were given the medication in the form of a capsule.…”

Section: Ppis Prescribed For Patientssupporting

confidence: 92%

“…PPIs are also used prophylactically with NSAIDs or steroids in individuals with a history of peptic ulcers, previous GI bleeding, or the elderly. 2 Due to these prevalent medical conditions, PPIs are one of the most often given drugs in the world, and there is a widespread notion that they have very low toxicity and good efficacy. However, evidence is accumulating that these drugs can cause a variety of bothersome and even life-threatening side effects.…”

Section: Introductionmentioning

confidence: 99%

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Study on Drug Utilization and Evaluation of Proton Pump Inhibitors in Surgery Unit of Tertiary Care Teaching Hospital

Ravindra¹,

K²,

Sunny³

et al. 2022

IJPSRR

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Proton pump inhibitors (PPIs) are one of the most commonly given prescribed drug in both outpatient and inpatient settings. Hence in this present scenario, where the use of PPIs is overwhelming, the present study aims to know the rational use of PPIs in the patients of General Surgery ward of a rural tertiary care hospital. The objective of the study is to study the drug utilization and evaluation of proton pump inhibitors in surgery unit at Adichunchanagiri Hospital and Research Center (AH&RC) BG Nagara, Mandya of tertiary care teaching hospital. A Prospective and Observational study was carried out for 6 months in the surgery department. A suitably designed patient profile form was used to record all the necessary data and the collected data is subjected to suitable statistical method for analysis. In the study, out of 200 patients on PPI, 73% were females and the rest were males. Most of the patients belonged to the age group of 36-55 years. PPIs were most frequently prescribed mainly to treat gastritis and to prevent the gastric irritation caused by analgesics. Most commonly prescribed PPIs were found to be Pantoprazole through IV route and oral route. Majority of the PPIs prescribed were appropriate based on NICE guidelines. Pantoprazole was the PPI having the greatest number of interactions with other drugs in the prescription and no ADRs were reported during our study period. PPIs should be used only when there is valid documented evidence and when their use is clinically justified. Various efforts should be made to reduce the unnecessary use of PPIs to minimize drug interactions, related risk, and the health care burden of the patients.

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Section: Ppis Prescribed For Patientssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%