Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology

Laccourreye, O.; Werner, Alfred; Laccourreye, L.; Bonfils, P.

doi:10.1016/j.anorl.2016.11.001

Cited by 15 publications

(17 citation statements)

References 64 publications

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“…Although this review included more placebo‐controlled studies of east‐Asian TMs than earlier reviews, some studies may have been missed. Also, the focus was on east‐Asian TMs, so it does not include other categories of traditional medicine and phytotherapy . Each of these limitations should be considered when interpreting results.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the focus was on east-Asian TMs, so it does not include other categories of traditional medicine and phytotherapy. 7 Each of these limitations should be considered when interpreting results.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…These are effective but long‐term medication adherence can be an issue . Traditional medicines (TMs) are used as adjunctive therapies for asthma in East‐Asia and have gained popularity in Western countries along with other forms of phytotherapy . Considering the widespread use of these TMs, it is important to determine whether combining TMs with conventional pharmacotherapies is safe and whether they confer additional benefits to inform physicians and assist them in discussions with patients.…”

Section: Introductionmentioning

confidence: 99%

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Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

Clyne

Yang

et al. 2019

Int J Clin Pract

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Background Traditional medicines (TMs) adjunctive to conventional medications are widely used for asthma in east‐Asia and have gained popularity in western countries. Objective To assess the efficacy and safety of TMs for asthma in children and adults based on placebo‐controlled trials in order to inform physicians and assist them in discussions with patients. Methods Seventeen electronic databases were searched. Participants had acute or chronic asthma. Interventions included orally administered traditional medicines used in east‐Asia. Outcomes included lung function, symptoms, quality of life, exacerbations, medication use and safety. RevMan 5.3 (random effect model) was used for meta‐analysis. Baseline values were assessed for balance and asthma severity. Within‐group changes were calculated to assess minimal clinically important difference (MCID). Results Eighteen studies (2080 participants) were included. All combined TMs with conventional medicines. The single study of acute asthma (n = 300) showed an improvement. For chronic asthma, severity at baseline ranged from very mild to severe. When asthma was mild, significant differences in lung function (FEV1%, PEF/R) were not detectable. When participants had moderate and/or severe asthma at baseline improvements were more evident. For measures of lung function, improvements within the TM groups tended to be greater when the asthma was more severe. Some studies showed MCIDs. No serious adverse events or interactions were reported but safety data were incomplete. Conclusions The application of certain traditional herbal medicines used in east‐Asia as adjuncts to conventional medications improved outcomes in acute and chronic asthma, but most evidence was based on single trials. Therefore, no single TM could be recommended. Effect sizes varied according to asthma severity at baseline. Future studies should consider baseline severity when enrolling participants.

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Section: Discussionmentioning

confidence: 99%

Section: Strengths and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

Clyne

Yang

et al. 2019

Int J Clin Pract

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“…1 Polyphenol-rich herbal extract prepared from a rootof Pelargonium sidoides (EPs 7630) is traditionally used in South Africa for treatment of respiratory, gastrointestinal infections, and dysmenorrhea. 6,7 Sir Charles Henry Stevens introduced this herbal drug to England in 1897, and more than seven decades later, a special extract of Pelargonium sidoides root, EPs 7630 was made. 7 This substance has been reported as having antimicrobial and anti-inflammatory effects, and few controlled studies reported its safety and efficiency in reducing symptoms of uncomplicated upper respiratory tract infections.…”

Section: Introductionmentioning

confidence: 99%

Herbal Drug EPs 7630versusAmoxicillin in Patients with Uncomplicated Acute Bacterial Rhinosinusitis: A Randomized, Open-Label Study

Perić

Gaćeša²,

Barać

et al. 2020

Ann Otol Rhinol Laryngol

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Objective: Previous investigations suggest the use of extract from the root of Pelargonium sidoides (EPs 7630) for the therapy of uncomplicated acute upper airway inflammations, due to its strong antimicrobial and immunomodulatory effect. We aimed to compare clinical efficacy, safety and bactericidal effect of EPs 7630 and amoxicillin monotherapy in treatment of patients with mild to moderate acute bacterial rhinosinusitis (ABRS). Methods: Fifty ABRS patients were divided into two groups by randomization. Group 1 (n = 25) received EPs 7630 tablets, 3 × 20 mg/day per os for 10 days. Group 2 (n = 25) received amoxicillin tablets 3 × 500 mg/day per os, for 10 days. We assessed total symptom score (TSS), individual symptom scores for each symptom (nasal obstruction, rhinorrhea, postnasal drip, facial pain/pressure, loss of the sense of smell), endoscopic findings, including total endoscopic score (TES) and individual endoscopic signs (mucosal edema, mucopurulent secretion), before and after treatment. Samples of discharge taken from the middle meatus of all patients were cultivated for bacteria before and after therapy. Results: Higher absolute improvement after treatment was found for TSS, nasal obstruction, facial pain/pressure, impaired sense of smell, TES, mucosal edema and mucopurulent secretion in EPs 7630 group compared to amoxicillin group ( P < .001 for all parameters). However, there were no differences in absolute improvement of rhinorrhea score and postnasal drip score between groups ( P = .248; P = .679, respectively). Fewer types of bacteria grew on culture from middle meatal samples in EPs 7630 group compared to amoxicillin group. There were no reported adverse events from patients from either group. Conclusion: Our results demonstrated better clinical and antimicrobial efficacy of EPs 7630 than amoxicillin. EPs 7630 was shown as a potent agent and good alternative to antibiotic treatment of uncomplicated ABRS.

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“…Herbal medicines have been used for centuries for the treatment of many disorders. In 2011, the World Health Organization estimated that 70-90% of population in developing countries and almost 20% in the United States used herbal drugs, whereas in Europe these percentages are estimated to 10-20% (8,9). The Myrtol® standardized, also known as GeloMyrtol® and GeloMyrtol® forte, with codifying number ELOM-080, is herbal medicine obtained through several steps of distillation of essential oils.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Myrtol® standardized in the therapy of acute and chronic rhinosinusitis: a review of the literature

Perić¹

2020

Erciyes Med J

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The clinical pattern of rhinosinusitis is based on key symptoms, including nasal obstruction/congestion, nasal secretion with postnasal discharge, facial pain with the sense of pressure, as well as impaired sense of smell. Acute rhinosinusitis usually becomes as a viral infection due to the impaired paranasal sinus aeration and drainage and this viral infection can be followed by bacterial superinfection. Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with symptoms persisting for more than twelve weeks. The aim of this paper is to summarize and update the relevant literature related to the use of herbal medicinal product Myrtol® standardized in the therapy of acute and chronic rhinosinusitis. According to the results of previous investigations, Myrtol® standardized is found to have a strong secretolytic, secretomotoric, antiinflammatory, antioxidative and antimicrobial effects. A review of the literature was carried out on randomized studies related to the use of this preparation in therapy of these forms of upper airway inflammations. We, also discussed the mechanisms of action of this herbal drug on diseased nasal and paranasal sinuses mucosa.

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Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology

Abstract: Scientific proof of the benefit of phytotherapy in otorhinolaryngology remains to be established but, given its widespread use and the reported data, knowledge of this form of treatment needs to be developed.

Cited by 15 publications

References 64 publications

Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

Traditional medicines for asthma in children and adults: A systematic review of placebo‐controlled studies

Herbal Drug EPs 7630versusAmoxicillin in Patients with Uncomplicated Acute Bacterial Rhinosinusitis: A Randomized, Open-Label Study

Efficacy and safety of Myrtol® standardized in the therapy of acute and chronic rhinosinusitis: a review of the literature

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