Benefits of whole ginger extract in prostate cancer

Abstract

It is appreciated far and wide that increased and regular consumption of fruits and vegetables is linked with noteworthy anticancer benefits. Extensively consumed as a spice in foods and beverages worldwide, ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds such as gingerols, paradols, shogaols and gingerones. Ginger has been known to display anti-inflammatory, antioxidant and antiproliferative activities, indicating its promising role as a chemopreventive agent. Here, we show that whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells. Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells. Remarkably, daily oral feeding of 100 mg/kg body weight of GE inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice, as shown by measurements of tumour volume. Tumour tissue from GE-treated mice showed reduced proliferation index and widespread apoptosis compared with controls, as determined by immunoblotting and immunohistochemical methods. Most importantly, GE did not exert any detectable toxicity in normal, rapidly dividing tissues such as gut and bone marrow. To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer.

Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways

“…However, other bioactive compounds are present in ginger and may be responsible for the enhanced anticancer effects observed with whole ginger extract compared with ginger compound research mixtures (e.g. gingerols and shogaols) (22,23,37,38). In the present study we examined a number of structurally diverse ginger compounds and discovered that gingerenone A exhibits potent and selective toxicity toward specific types of cancer cells.…”

“…Natural bioactive compounds provide a wealth of structural diversity, and their investigation for targeted therapies can offer promising opportunities to identify novel anticancer agents and aid in the understanding of cancer cell signaling (20,21). Ginger (Zingiber officinale) has been reported to exhibit strong chemopreventive and chemotherapeutic properties in various cancer models, underlining its potential for clinical application (22)(23)(24)(25)(26). Gingerols are the most abundant form of aromatic compound present in ginger root and have been extensively studied for their anti-cancer effects (27)(28)(29)(30)(31).…”

Evaluation of Antifungal Activity of a 3-Extract Formulation in Topical Dosage Form and Its Safety Aspect

“…For instance, digestive disorder, hypertension, inflammation, and cold are common diseases where ginger can be used [11]. The marker compounds contained in ginger, particularly gingerol and shogaol, have been reported exhibit important antioxidant properties with remarkable anticancer, and antimutagenic effect [12], analgesic [13], inhibit melanoma [11], inhibit platelet aggregation [14], antihyperlipidemia [15], antidiabetes [16], ameliorate renal and pancreas damage [17], and so on. Certain compounds contained in (Z. officinale) demonstrate synergistic effect as auxiliary chemical agent against on C. albicans, Enterococcus faecalis, Escherichia coli, and their endotoxins [18] and also other microbes [19].…”

Anticancer Herbs for Improving the Quality of Life

“…-11, 2018 The mechanism showing the antitumor activity, stimulating the lymphocytes and macrophages used to kill cancer cells and interfaces with tumour cells metabolism is shown in figure 7. Studies suggest that the ginger and its bioactive constituents such as gingerol, paradols and shogals [74] and they are useful in cancer prevention and treatment [89]. Gingerols isolated from Zingiber officinale inhibits growth & spread of various cancers including that of the ovary, cervix, colon, rectum, liver, urinary bladder, oral cavity, neuroblastoma and leukaemia by inducing apoptosis [24].…”