Benefits of the antioxidant and anti‐inflammatory activity of etoricoxib in the prevention of ovarian ischemia/reperfusion injury induced experimentally in rats

Abstract

Etoricoxib prevented oxidative damage induced with I/R in rat ovarian tissue. This property of etoricoxib suggests that it can be clinically beneficial in the prevention of damage that may arise with reperfusion by detorsion for the protection of the ovaries against torsion.

Effects of curcumin on ovarian ischemia-reperfusion injury in a rat model

“…rats (17). This is consistent with other rat studies indicating a protective effect of ROS-scavenging and anti-inflammatory agents in ovarian reperfusion injury, such as etoricoxib (18) and hesperidin (19). Additionally, another flavonoid, quercetin, has also been shown to have protective effects against apoptosis and ischemia-modified albumin levels in a rat model of ovarian ischemia-reperfusion injury, thus protecting against tissue injury (20).…”

“…For example, in a study on liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease, a protective effect of curcumin was mediated via reduction in lung inflammation and matrix metalloprotease-9 activity (30). Other rat studies have shown a protective effect of the agents with ROS-scavenging and anti-inflammatory capacity in ovarian reperfusion injury, for example, etoricoxib (18) and hesperidin (19). Another flavonoid, quercetin, has been shown to have anti-apoptotic effects in a rat model of ovarian ischemia-reperfusion injury (20).…”

Effect of Kineret® on ovarian ischemia reperfusion injury in a rat model

“…Similiarly, previous studies have reported high MPO activity and MDA levels in the ovarian tissues of rat groups subjected to IR. 25 MPO is a myeloperoxidase enzyme released from activated neutrophils and catalizes the reaction of hydrogen peroxide with chlorine ions in the tissues, forming hypochloric acid. Hypochloric acid inactivates α1-antiproteinase, causing tissue damage.…”

Adnexal torsion in adolescents

“…Assuming that detorsion can provoke this injury and alone is insufficient to protect ovarian reserve as the follicle count decreases (Ozler et al [38]), several agents, including antiinflammatories and antioxidant drugs, have been evaluated to determine whether they have a protective effect [36]. Experimental studies were performed on rat ovaries to demonstrate the role of different drugs in the protection of ovarian function [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]. Gradual detorsion can also reduce reperfusion injury in a rat model of ovarian torsion [37].…”