Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates

Abstract

Background/Aims: Lumican, a small leucine-rich proteoglycan, has shown osteoprotective effects by synchronously stimulating bone formation and suppressing bone resorption. To clarify the role of lumican in human bone metabolism, the association between lumican concentrations and osteoporosis-related phenotypes was evaluated using bone marrow (BM) samples directly reflecting local microenvironments.Methods: BM aspirates were obtained from 77 patients during hip surgery for either fragility hip fractures (HF) (n = 29) or osteoarthritis (n = 48) and centrifuged. Concentrations of lumican and biochemical bone markers in BM supernatants were measured using enzyme linked immunosorbent assays.Results: After considering confounders, lumican concentrations in BM supernatants were 16.9% lower in patients with HF than in controls, with each increase in the standard deviation of lumican concentration being associated with a 61% lower likelihood of HF. The odds ratios for HF decreased linearly with increasing lumican tertiles in BM, with the odds of having fragility HF markedly lower in participants in the highest than in the lowest lumican tertile. Higher lumican level correlated significantly with higher femur neck bone mineral density and higher bone-specific alkaline phosphatase levels, but not with tartrate-resistant acid phosphatase 5b concentrations, in BM supernatants.Conclusions: These data clinically validate previous <i>in vitro</i> and animal experiments showing the beneficial roles of lumican for bone homeostasis and suggest that lumican may contribute to a reduction in fracture risk in humans mainly through its stimulation of bone formation.

Lumican is a potential predictor on the efficacy of concurrent chemoradiotherapy in cervical squamous cell carcinoma

“…LUM (Lumican) is a member of the small leucine-rich proteoglycans family, located on chromosome 12q21.3-q22 [ 15 , 16 ]. LUM is predominantly expressed in connective tissues and participates in tissue reconstruction [ [16] , [17] , [18] ].…”

“…LUM (Lumican) is a member of the small leucine-rich proteoglycans family, located on chromosome 12q21.3-q22 [ 15 , 16 ]. LUM is predominantly expressed in connective tissues and participates in tissue reconstruction [ [16] , [17] , [18] ]. Recent studies have demonstrated that LUM is involved in various tumor-related cellular processes such as epithelial-mesenchymal transformation, cell proliferation, migration, invasion, and adhesion [ 19 , 20 ].…”