Benefits of Deep Transcranial Magnetic Stimulation in Alzheimer Disease

Avirame, Keren; Stehberg, Jimmy; Todder, Doron

doi:10.1097/yct.0000000000000286

Cited by 19 publications

(14 citation statements)

References 51 publications

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“…This kind of deep stimulation is named deep TMS (dTMS). Avirame et al [57] used dTMS at 10 Hz to stimulate deep prefrontal bilateral hub regions in 20 sessions in patients with moderate to severe AD. The cognitive assessment has been performed before and after the treatment using a computerised cognitive test (Minsdtreams; NeuroTrax Corp., Bellaire, TX, USA) and the Addenbrooke Cognitive Examination (ACE).…”

Section: Transcranial Magnetic Stimulation-tmsmentioning

confidence: 99%

A Scoping Review of Neuromodulation Techniques in Neurodegenerative Diseases: A Useful Tool for Clinical Practice?

2021

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Background and Objectives: Neurodegenerative diseases that typically affect the elderly such as Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia are typically characterised by significant cognitive impairment that worsens significantly over time. To date, viable pharmacological options for the cognitive symptoms in these clinical conditions are lacking. In recent years, various studies have employed neuromodulation techniques to try and contrast patients’ decay. Materials and Methods: We conducted an in-depth literature review of the state-of-the-art of the contribution of these techniques across these neurodegenerative diseases. Results: The present review reports that neuromodulation techniques targeting cognitive impairment do not allow to draw yet any definitive conclusion about their clinical efficacy although preliminary evidence is very encouraging. Conclusions: Further and more robust studies should evaluate the potentialities and limitations of the application of these promising therapeutic tools to neurodegenerative diseases.

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Section: Transcranial Magnetic Stimulation-tmsmentioning

confidence: 99%

A Scoping Review of Neuromodulation Techniques in Neurodegenerative Diseases: A Useful Tool for Clinical Practice?

2021

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“…Transcranial magnetic stimulation (TMS) was developed by Barker in 1985 as a non-invasive, safe and painless method for the stimulation of the brain. A growing number of studies suggested a therapeutic effect for repetitive transcranial magnetic stimulation (rTMS) on some neurological disorders and other psychiatric disorders, such as Parkinson's disease, Alzheimer's disease and depression (Avirame et al 2016, Ba et al 2017, Cacace et al 2017, Mi et al 2017, Reyes-Lopez et al 2018. The rTMS has been authorized for use in resistant depression patients by US FDA.…”

Section: Introductionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Hippocampal Structural Synaptic Plasticity in Rats

Pan

2018

Physiol Res

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Repetitive transcranial magnetic stimulation (rTMS) was shown to have therapeutic potential for some neurological and psychiatric disorders. Previous studies reported that low-frequency rTMS (</=1 Hz) affected synaptic plasticity in rats, however, there were few investigations to examine the possible effects of rTMS on structural synaptic plasticity changes in rats, which included the effects on synaptic morphology in the hippocampus, synaptic protein markers and Ca(2+)/calmodulin-dependent protein II (CaMKII). Sprague-Dawley rats were subject to 500 pulses of 0.5 Hz rTMS for 15 days, or sham stimulation. After last stimulation, transmission electron microscope (TEM) and real-time PCR were used to determine the effects of rTMS on synaptic plasticity. Results showed that rTMS could cause the change of structural synaptic plasticity, increase the expression of synaptic protein markers: synaptophysin (SYN) and increase the expression of CaMKII, relative to normal rats. suggesting a modulatory effect of chronic rTMS on synaptic plasticity that may be attributed to the increased expression of CaMKII in rats.

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“…Of all TMS studies, figure-of-eight coil was used the most (15 studies, 77%). One study used a double-cone coil (Sole-Padulles et al, 2006) and an H2 coil was equipped in another (Avirame et al, 2016). The shape or type of the coil was not mentioned in four studies (Rutherford et al, 2015;Lee et al, 2016;Zhao et al, 2017).…”

Section: Target Region Localization Methods and Type Of The Coilmentioning

confidence: 99%

“…DSM criteria were applied in 7 studies (27%) alone or in addition to other criteria. Three of the studies reported only that the diagnostic decision was made by an expert (Penolazzi et al, 2015;Rutherford et al, 2015;Avirame et al, 2016). To define MCI, various criteria were used, including the original criteria of Petersen et al (1999) and its different revisions (Petersen et al, 1999;Portet et al, 2006;Albert et al, 2011).…”

Section: Sample Characteristicsmentioning

confidence: 99%

“…To define MCI, various criteria were used, including the original criteria of Petersen et al (1999) and its different revisions (Petersen et al, 1999;Portet et al, 2006;Albert et al, 2011). Overall, we identified 6 studies that did not specify how the diagnosis was established (18%) (Eliasova Marra et al, 2015;Rutherford et al, 2015;Avirame et al, 2016;Rabey and Dobronevsky, 2016;Nguyen et al, 2017). Additional exclusion criteria were listed in almost every study.…”

Section: Sample Characteristicsmentioning

confidence: 99%

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Non-invasive Brain Stimulation in Alzheimer's Disease and Mild Cognitive Impairment—A State-of-the-Art Review on Methodological Characteristics and Stimulation Parameters

Holczer

Németh

Vékony

et al. 2020

Front. Hum. Neurosci.

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Background: Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been proposed as a new therapeutic way to enhance the cognition of patients with dementia. However, serious methodological limitations appear to affect the estimates of their efficacy. We reviewed the stimulation parameters and methods of studies that used TMS or tDCS to alleviate the cognitive symptoms of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Moreover, we evaluated the risk of bias in these studies. Our aim was to highlight the current vulnerabilities of the field and to formulate recommendations on how to manage these issues when designing studies.Methods: Electronic databases and citation searching were used to identify studies administering TMS or tDCS on patients with AD or MCI to enhance cognitive function. Data were extracted by one review author into summary tables with the supervision of the authors. The risk of bias analysis of randomized-controlled trials was conducted by two independent assessors with version 2 of the Cochrane risk-of-bias tool for randomized trials.Results: Overall, 36 trials were identified of which 23 randomized-controlled trials underwent a risk of bias assessment. More than 75% of randomized-controlled trials involved some levels of bias in at least one domain. Stimulation parameters were highly variable with some ranges of effectiveness emerging. Studies with low risk of bias indicated TMS to be potentially effective for patients with AD or MCI while questioned the efficacy of tDCS. Conclusions:The presence and extent of methodical issues affecting TMS and tDCS research involving patients with AD and MCI were examined for the first time. The risk of bias frequently affected the domains of the randomization process and selection of the reported data while missing outcome was rare. Unclear reporting was present involving Holczer et al.NIBS in Dementia: Methodological Issues randomization, allocation concealment, and blinding. Methodological awareness can potentially reduce the high variability of the estimates regarding the effectiveness of TMS and tDCS. Studies with low risk of bias delineate a range within TMS parameters seem to be effective but question the efficacy of tDCS.

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Benefits of Deep Transcranial Magnetic Stimulation in Alzheimer Disease

Abstract: In sum, the current report of this novel technique indicates that deep stimulation might lead to preservation and even improvement of cognitive functions, at least during the time of treatment. Further examinations should report of long-term effects of this technique.

Cited by 19 publications

References 51 publications

A Scoping Review of Neuromodulation Techniques in Neurodegenerative Diseases: A Useful Tool for Clinical Practice?

A Scoping Review of Neuromodulation Techniques in Neurodegenerative Diseases: A Useful Tool for Clinical Practice?

Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Hippocampal Structural Synaptic Plasticity in Rats

Non-invasive Brain Stimulation in Alzheimer's Disease and Mild Cognitive Impairment—A State-of-the-Art Review on Methodological Characteristics and Stimulation Parameters

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