Benefits of contrast-enhanced SWI in patients with glioblastoma multiforme

Fahrendorf, Delia M.; Schwindt, Wolfram; Wölfer, Johannes; Jeibmann, Astrid; Kooijman, Hendrik; Kugel, Harald; Grauer, Oliver; Heindel, Walter; Heßelmann, Volker; Bink, Andrea

doi:10.1007/s00330-013-2895-x

Cited by 27 publications

(22 citation statements)

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“…However, current evidence is confined to a limited number of studies [31]. It remains doubtful what information SWI can offer above other MRI sequences in glioma, with a possible exception of tumour margin delineation on contrast-enhanced SWI [32]. …”

Section: Discussionmentioning

confidence: 99%

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

et al. 2018

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ObjectivesAt a European Society of Neuroradiology (ESNR) Annual Meeting 2015 workshop, commonalities in practice, current controversies and technical hurdles in glioma MRI were discussed. We aimed to formulate guidance on MRI of glioma and determine its feasibility, by seeking information on glioma imaging practices from the European Neuroradiology community.MethodsInvitations to a structured survey were emailed to ESNR members (n=1,662) and associates (n=6,400), European national radiologists’ societies and distributed via social media.ResultsResponses were received from 220 institutions (59% academic). Conventional imaging protocols generally include T2w, T2-FLAIR, DWI, and pre- and post-contrast T1w. Perfusion MRI is used widely (85.5%), while spectroscopy seems reserved for specific indications. Reasons for omitting advanced imaging modalities include lack of facility/software, time constraints and no requests. Early postoperative MRI is routinely carried out by 74% within 24–72 h, but only 17% report a percent measure of resection. For follow-up, most sites (60%) issue qualitative reports, while 27% report an assessment according to the RANO criteria. A minority of sites use a reporting template (23%).ConclusionClinical best practice recommendations for glioma imaging assessment are proposed and the current role of advanced MRI modalities in routine use is addressed.Key Points• We recommend the EORTC-NBTS protocol as the clinical standard glioma protocol.• Perfusion MRI is recommended for diagnosis and follow-up of glioma.• Use of advanced imaging could be promoted with increased education activities.• Most response assessment is currently performed qualitatively.• Reporting templates are not widely used, and could facilitate standardisation.Electronic supplementary materialThe online version of this article (10.1007/s00330-018-5314-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

et al. 2018

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“…As a useful diagnostic sequence, SWI has been widely applied, e.g. for detecting or evaluating intracranial haemorrhage, calcification, cerebral venous thrombosis, tumour evolution [14,15] or haemorrhagic transformation of stroke [16][17][18], using the parametric properties of deoxyhaemoglobin. SWI has been described inter alia to be helpful in detecting occult calcified lesions or vascular malformations that may be responsible for seizures [19].…”

Section: Introductionmentioning

confidence: 99%

Focal hemodynamic patterns of status epilepticus detected by susceptibility weighted imaging (SWI)

et al. 2014

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“…For T1w- and T2w-imaging, patients were intravenously injected with chelated gadolinium (Gadovist, Bayer Vital GmbH, Leverkusen, Germany: 1 mmol/mL, ie, 1 mL = 604.72 mg gadobutrol = 157.25 mg gadolinium) with a concentration of 0.1 mmol/kg body weight. 22 Further MRI details are indicated in Supplements (II).…”

Section: Methodsmentioning

confidence: 99%

Multimodal Imaging of Patients With Gliomas Confirms ¹¹C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy

et al. 2017

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The value of combined L-(methyl-[11C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicion of a brain tumor was investigated. In n = 65 patients with histologically verified brain lesions n = 70 MET-PET and MRI (T1-weighted gadolinium-enhanced [T1w-Gd] and fluid-attenuated inversion recovery or T2-weighted [FLAIR/T2w]) examinations were performed. The computer software “visualization and analysis framework volume rendering engine (Voreen)” was used for analysis of extent and intersection of tumor compartments. Binary logistic regression models were developed to differentiate between World Health Organization (WHO) tumor types/grades. Tumor sizes as defined by thresholding based on tumor-to-background ratios were significantly different as determined by MET-PET (21.6 ± 36.8 cm3), T1w-Gd-MRI (3.9 ± 7.8 cm3), and FLAIR/T2-MRI (64.8 ± 60.4 cm3; P < .001). The MET-PET visualized tumor activity where MRI parameters were negative: PET positive tumor volume without Gd enhancement was 19.8 ± 35.0 cm3 and without changes in FLAIR/T2 10.3 ± 25.7 cm3. FLAIR/T2-MRI visualized greatest tumor extent with differences to MET-PET being greater in posttherapy (64.6 ± 62.7 cm3) than in newly diagnosed patients (20.5 ± 52.6 cm3). The binary logistic regression model differentiated between WHO tumor types (fibrillary astrocytoma II n = 10 from other gliomas n = 16) with an accuracy of 80.8% in patients at primary diagnosis. Combined PET and MRI improve the evaluation of tumor activity, extent, type/grade prediction, and therapy-induced changes in patients with glioma and serve information highly relevant for diagnosis and management.

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Benefits of contrast-enhanced SWI in patients with glioblastoma multiforme

Cited by 27 publications

References 25 publications

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

Focal hemodynamic patterns of status epilepticus detected by susceptibility weighted imaging (SWI)

Multimodal Imaging of Patients With Gliomas Confirms ¹¹C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy

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Benefits of contrast-enhanced SWI in patients with glioblastoma multiforme

Cited by 27 publications

References 25 publications

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice

Focal hemodynamic patterns of status epilepticus detected by susceptibility weighted imaging (SWI)

Multimodal Imaging of Patients With Gliomas Confirms 11C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy

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Multimodal Imaging of Patients With Gliomas Confirms ¹¹C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy