Benefits of cardiac resynchronization therapy in outpatients with indicators for heart transplantation

Greenberg, Jeffrey M.; León, Angel R.; Book, Wendy; Hott, Brenda; Delurgio, David B.; Langberg, Jonathan J.; Smith, Andrew L.

doi:10.1016/s1053-2498(02)01190-7

Cited by 8 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27 In contrast, evidence suggests that correction of intra-and interventricular dyssynchrony by CRT favorably modifies quality of life, morbidity and hospitalization rate in congestive heart failure. 26,28 Our observation of improved symptoms and LV function in parallel with an increase in oxygen uptake after CRT supports recent data from Greenberg et al 29 Furthermore, in addition to improved morbidity, our data also indicate that CRT can delay heart transplantation in some patients with documented dyssynchrony. In fact, at 1-year follow-up, the vast majority of CRT patients did not meet inclusion criteria for cardiac transplantation, 30 and were successfully removed from the waiting list.…”

Section: Discussionsupporting

confidence: 90%

Cardiac Resynchronization Therapy Delays Heart Transplantation in Patients With End-stage Heart Failure and Mechanical Dyssynchrony

Vanderheyden

Wellens

Bartúnek

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Cardiac Resynchronization Therapy Delays Heart Transplantation in Patients With End-stage Heart Failure and Mechanical Dyssynchrony

Vanderheyden

Wellens

Bartúnek

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…There are some reports on CRT as a successful bridge to transplantation among ambulatory patients [11, 12], but there are only a few data regarding CRT implantation among patients with refractory heart failure receiving intravenous inotropic treatment [9]. We hypothesized that patients with decompensated class IV HF and a significant intraventricular conduction delay who receive intravenous inotropic agents would benefit from urgent CRT implantation.…”

Section: Discussionmentioning

confidence: 99%

Urgent Cardiac Resynchronization Therapy in Patients with Decompensated Chronic Heart Failure Receiving Inotropic Therapy

et al. 2006

View full text Add to dashboard Cite

Background: It remains unknown whether patients with severe decompensated class IV heart failure (HF) receiving intravenous inotropic treatment benefit from cardiac resynchronization therapy (CRT). Methods: We identified patients who underwent urgent CRT implantation due to decompensated class IV HF necessitating intravenous inotropic therapy. Results: Of 10 patients with chronic ischemic cardiomyopathy (median QRS duration of 170 ms), CRT implantation was associated with symptomatic improvement in 8 patients. The mortality rate was 50% during a median follow-up of 9.5 months, with a median CRT-to-death duration of 6 months. Conclusions: CRT was feasible among class IV patients receiving inotropic treatment and was associated with clinical improvement.

show abstract

“…29 Furthermore, data on CRT in patients with end-stage heart failure awaiting HT are limited to small retrospective studies. 30 Although information on the outcomes of CRT defibrillator implantation in the current study is lacking, the need for transplant listing suggests these patients were likely nonresponders, and the additive benefit of CRT to ICD on decreasing waitlist mortality and prevention of SCD may not be significant.…”

Section: Survival Benefit Of Icd Implantation In Patients Awaiting Htmentioning

confidence: 83%

Association between implantable cardioverter-defibrillator and survival in patients awaiting heart transplantation: A meta-analysis and systematic review

et al. 2021

View full text Add to dashboard Cite

BACKGROUND Patients with end-stage heart failure are at high risk for sudden cardiac death. However, implantable cardioverterdefibrillator (ICD) is not routinely implanted given the high competing risk of pump failure. A unique population worth separate consideration are patients with end-stage heart failure awaiting heart transplantation, as prolonged survival improves the chances of receiving transplant.OBJECTIVE To compare clinical outcomes of heart failure patients with and without an ICD awaiting heart transplant. METHODSWe performed an extensive literature search and systematic review of studies that compared end-stage heart failure patients with and without an ICD awaiting heart transplantation. We separately assessed the rates of total mortality, sudden cardiac death, nonsudden cardiac death, and heart transplantation. Risk ratio (RR) and 95% confidence intervals were measured using the Mantel-Haenszel method. The random effects model was used owing to heterogeneity across study cohorts. RESULTSTen studies with a total of 36,112 patients were included. A total of 62.5% of patients had an ICD implanted. Patients with an ICD had decreased total mortality (RR 0.60, 95% CI 0.51-0.71, P , .00001) and sudden cardiac death (RR 0.27, 95% CI 0.11-0.66, P 5 .004) and increased rates of heart transplantation (RR 1.09, 95% CI 1.05-1.14, P , .0001). There was no difference in prevalence of nonsudden cardiac death (RR 0.68, 95% CI 0.44-1.04, P 5 .07).CONCLUSION ICD implantation is associated with improved outcomes in patients awaiting heart transplant, characterized by decreased total mortality and sudden cardiac death as well as higher rates of heart transplantation.

show abstract

Benefits of cardiac resynchronization therapy in outpatients with indicators for heart transplantation

Cited by 8 publications

References 21 publications

Cardiac Resynchronization Therapy Delays Heart Transplantation in Patients With End-stage Heart Failure and Mechanical Dyssynchrony

Cardiac Resynchronization Therapy Delays Heart Transplantation in Patients With End-stage Heart Failure and Mechanical Dyssynchrony

Urgent Cardiac Resynchronization Therapy in Patients with Decompensated Chronic Heart Failure Receiving Inotropic Therapy

Association between implantable cardioverter-defibrillator and survival in patients awaiting heart transplantation: A meta-analysis and systematic review

Contact Info

Product

Resources

About