Benefits of an All‐Liquid Ketogenic Diet

Kossoff, Eric H.; McGrogan, Jane R.; Freeman, John M.

doi:10.1111/j.0013-9580.2004.18504.x

Cited by 58 publications

(47 citation statements)

References 4 publications

(3 reference statements)

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“…In our cohort, the KD was very effective in infants with responder rates of 63.8%, similar to those described in the literature (54.9-67%) (Nordli et al, 2001;Kossoff et al, 2008aKossoff et al, , 2002Kossoff et al, , 2004Rubenstein et al, 2005;Hong et al, 2010). However, a higher number (34.5%) of infants than older children (19%) became seizure free and remained so (32.7% vs. 17% at 6 and 12 months), even after withdrawal of the diet (6 months post diet and last follow up 30.6% vs. 3.9%).…”

Section: Discussionsupporting

confidence: 89%

“…Compliance was significantly better in fluid fed infants as dropouts due to food refusal were not observed compared with rates as high as 30% observed in solid-fed toddlers and older children (Kossoff et al, 2004). Results were similar in our study were initial drop-outs were observed to a higher extent in older children (7.3% in older children vs. 3.3% in infants).…”

Section: Discussionsupporting

confidence: 83%

“…A fluid KD is an important option in this group of infants since liquid formulae with an acceptable taste similar to that of most other infant formulae and adjusted for vitamins, calcium, and trace minerals have been licensed (Kang et al, 2006;Kossoff et al, 2004;Rubenstein, 2008;Rubenstein et al, 2005). Kossoff and co-workers (Kossoff et al, 2008b) showed excellent responder rates of >90% reduction in seizure frequency, but data on seizure freedom rates in infants have not been reported.…”

Section: Discussionmentioning

confidence: 99%

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The ketogenic diet in infants – Advantages of early use

et al. 2015

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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The ketogenic diet in infants – Advantages of early use

et al. 2015

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“…Interestingly, success of the KD in this cohort may be due in part to an infant's primary dependency on an all-liquid KD. Studies that have evaluated formula-based administration, whether fed via bottle or gastrostomy tube, indicate better compliance and ultimately better seizure control compared with the typical solid-food diet [15,16]. In recent years, many KD centers have found that dependency on gastrostomy tubes, regardless of age, may represent a special indication for the KD in patients with otherwise intractable seizures or intolerable side effects to anticonvulsant drugs.…”

Section: Indicationsmentioning

confidence: 99%

State of the ketogenic diet(s) in epilepsy

Huffman¹,

Kossoff

2006

Curr Neurol Neurosci Rep

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Fasting has been recognized as a treatment for seizures since ancient times. The ketogenic diet is a low-carbohydrate, adequate-protein, high-fat diet that biochemically mimics the fasting state and has been used to successfully treat seizures for 85 years. The diet has enjoyed a resurgence in popularity over the past decade and is gaining acceptance and use worldwide. Many studies over the past several years have explored possible mechanisms of action for the ketogenic diet. This review addresses these studies, as well as recent research regarding possible indications for the diet, variations in its initiation, side effect profiles, and the recent use of modified formulations to improve tolerability.

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“…From this perspective, since 1990s, the ketogenic diet (KD) is emerging as one of the effective therapies with relatively reduced side effects particularly in difficult-tocontrol epilepsies (Freeman et al, 2006(Freeman et al, , 2007. A number of studies suggest that KD is more effective for the management of refractory epilepsy in children than other currently available anticonvulsant medications Vining et al, 1998;Kossoff, 2004;Kossoff et al, 2004;Kossoff and McGrogan, 2005). Moreover, the availability of several infant formulas of the KD makes this approach more convenient for treating children with epilepsy (Nordli et al, 2001;Klepper et al, 2002).…”

Section: Neuroprotection Using the Ketogenic Dietmentioning

confidence: 99%

Progress in neuroprotective strategies for preventing epilepsy

Acharya

Hattiangady

Shetty

2008

Progress in Neurobiology

157

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Neuroprotection is increasingly considered as a promising therapy for preventing and treating temporal lobe epilepsy (TLE). The development of chronic TLE, also termed as epileptogenesis, is a dynamic process. An initial precipitating injury (IPI) such as the status epilepticus (SE) leads to neurodegeneration, abnormal reorganization of the brain circuitry and a significant loss of functional inhibition. All of these changes likely contribute to the development of chronic epilepsy, characterized by spontaneous recurrent motor seizures (SRMS) and learning and memory deficits. The purpose of this review is to discuss the current state of knowledge pertaining to neuroprotection in epileptic conditions, and to highlight the efficacy of distinct neuroprotective strategies for preventing or treating chronic TLE. Although the administration of certain conventional and new generation antiepileptic drugs is effective for primary neuroprotection such as reduced neurodegeneration after acute seizures or the SE, their competence for preventing the development of chronic epilepsy after an IPI is either unknown or not promising. On the other hand, alternative strategies such as the ketogenic diet therapy, administration of distinct neurotrophic factors, hormones or antioxidants seem useful for preventing and treating chronic TLE. However, long term studies on the efficacy of these approaches introduced at different time-points after the SE or an IPI are lacking. Additionally, grafting of fetal hippocampal cells at early time-points after an IPI holds considerable promise for preventing TLE, though issues regarding availability of donor cells, ethical concerns, timing of grafting after SE, and durability of graft-mediated seizure suppression need to be resolved for further advances with this approach. Overall, from the studies performed so far, there is consensus that neuroprotective strategies need to be employed as quickly as possible after the onset of the SE or an IPI for considerable beneficial effects. Nevertheless, ideal strategies that are capable of facilitating repair and functional recovery of the brain after an IPI and preventing the evolution of IPI into chronic epilepsy are still hard to pin down.

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Benefits of an All‐Liquid Ketogenic Diet

Cited by 58 publications

References 4 publications

The ketogenic diet in infants – Advantages of early use

The ketogenic diet in infants – Advantages of early use

State of the ketogenic diet(s) in epilepsy

Progress in neuroprotective strategies for preventing epilepsy

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