Benefits of Aerobic Exercise for Breast Cancer Survivors: A Systematic Review of Randomized Controlled Trials

Bekhet, Amira Hassan; Abd-Allah, Adel R. A.; Ismail, Horeya M.; Genena, Doaa; Na, Osman; Khatib, Ayman El; Abbas, Rami

doi:10.31557/apjcp.2019.20.11.3197

Cited by 28 publications

(42 citation statements)

References 35 publications

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“…Investigators are increasingly incorporating exercise training and physical activity into practice and in clinical trials to improve quality of life, [117][118][119][120] improve cardiorespiratory function, [121][122][123] and even as a preventive and/ or therapeutic anticancer intervention. 124 Exercise was proposed as an immunotherapy by de Araújo et al as a way to counter immunosenescense in aging cancer patients.…”

Section: Incorporation Of Exercise Into Clinical Applications and Translationmentioning

confidence: 99%

Exercise and the immune system: taking steps to improve responses to cancer immunotherapy

Gustafson

Wheatley‐Guy

Rosenthal

et al. 2021

J Immunother Cancer

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The remarkable success of cancer immunotherapies has provided new hope to cancer patients. Unfortunately, a significant proportion of patients remain unable to respond to immunotherapy or maintain durable clinical responses. The lack of objective responses likely results from profound immune dysfunction often observed in patients with cancer. There is substantial evidence that exercise and physical activity can reduce incidence and improve outcomes in cancer patients. As the immune system is highly responsive to exercise, one potential avenue to improve immune function is through exercise and physical activity. A single event of dynamic exercise results in the substantial mobilization of leukocytes with increased functional capacities into the circulation. Chronic, or long-term, exercise leads to higher physical fitness in terms of greater cardiorespiratory function and/or muscle strength and endurance. High aerobic capacity, as measured by maximal oxygen uptake, has been associated with the reduction of dysfunctional T cells and improvements in the abundance of some T cell populations. To be sure, however, the mechanisms of exercise-mediated immune changes are both extensive and diverse. Here, we examine the evidence and theorize how acute and chronic exercise could be used to improve responses to cancer immunotherapies including immune checkpoint inhibitors, dendritic cell vaccines, natural killer cell therapies, and adoptive T cell therapies such as chimeric antigen receptor (CAR) T cells. Although the parameters of optimal exercise to yield defined outcomes remain to be determined, the available current data provide a compelling justification for additional human studies and clinical trials investigating the adjuvant use of exercise in immuno-oncology.

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Section: Incorporation Of Exercise Into Clinical Applications and Translationmentioning

confidence: 99%

Exercise and the immune system: taking steps to improve responses to cancer immunotherapy

Gustafson

Wheatley‐Guy

Rosenthal

et al. 2021

J Immunother Cancer

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“…Isso resulta em um estilo de vida mais saudável, identificado por benefícios como: redução de problemas psicológicos, melhoria da qualidade de vida, prevenção e recuperação de doenças crônicas não transmissíveis e infeccionas, melhora do funcionamento do metabolismo e da saúde de maneira geral (AXSOM; LIBONATI, 2019; BEKHET et al, 2019;DAVIS et al, 2019;LORA-POZO, 2019;SPEER et al, 2019;VAINSHELBOIM et al, 2019;WANG et al, 2019;BREDIN, 2019).…”

Section: ) E Relações Das Medidas Antropométricas (Lohman; Roche; Martorell 1988)unclassified

Portfólio Diário De Atividades Online Como Ferramenta De Avaliação De Curso De Pós-Graduação

Colchon¹,

Porfírio²

2021

Educação Para Atividade Física E Saúde

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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“…Physical activity has been shown to reduce the incidence of cancer and improve patient-oriented outcomes such as fatigue and depression in those with cancer both during and after treatment. 10,11,[27][28][29] Compared with low levels of moderate to vigorous leisure-time activity, high levels are associated with signifi cant reductions in the incidence of common cancers affecting women, including breast cancer (hazard ratio [HR] 0.90, 95% confi dence interval [CI] 0.87-0.93), lung cancer (HR 0.74, 95% CI 0.71-0.77), and colon cancer (HR 0.84, 95% CI 0.77-0.91). 10 Observational studies consistently demonstrate reductions in overall and cancer-related mortality associated with increasing levels and intensity of physical activity.…”

Section: Cancermentioning

confidence: 99%

“…28 Walking improves sleep, depression, anxiety, and cancer-related fatigue. 29 Exercise, particularly if supervised by a professional, may have lasting, although small to moderate, benefi ts compared with usual care for improving pain, emotional well-being, social functioning,…”

Section: Cancermentioning

confidence: 99%

Promoting physical activity in older women to maximize health

Chavez

Scales

Kling

2021

CCJM

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Physical activity can maximize health by improving disease-oriented and patient-oriented outcomes in women age 60 and older. General activity levels are low in the United States. Promoting physical activity in clinical practice is limited by time constraints and knowledge defi cits. Understanding the benefi ts of the specifi c type of physical activity, the intensity, and the level in older women helps clinicians provide focused, time-effi cient counseling in primary care. This review details the benefi ts of physical activity in older women by disease state. KEY POINTSSex-specifi c differences in diseases exist for older women.The leading causes of disability and death in women over age 60 are cardiovascular disease, stroke, hypertension, diabetes mellitus, hyperlipidemia, cancer, cognitive decline, chronic obstructive pulmonary disease, depression, musculoskeletal disorders, osteoporosis, and falls, all of which are improved by physical activity.Primary care counseling on routine physical activity and exercise can increase the level of activity in women age 60 and older and improve clinical outcomes.

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Benefits of Aerobic Exercise for Breast Cancer Survivors: A Systematic Review of Randomized Controlled Trials

Abstract: The survival outcome in BC survivors is likely to have some correlation with exercise; long-term physical activity levels are important for BC prognosis and are associated

Cited by 28 publications

References 35 publications

Exercise and the immune system: taking steps to improve responses to cancer immunotherapy

Exercise and the immune system: taking steps to improve responses to cancer immunotherapy

Portfólio Diário De Atividades Online Como Ferramenta De Avaliação De Curso De Pós-Graduação

Promoting physical activity in older women to maximize health

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