Benefits of a nurse-led home injection service for acromegaly patients treated with somatuline autogel

Akirov, Amit; Masri-Iraqi, Hiba; Gorshtein, Alexander; Duskin-Bitan, Hadar; Kaminer, Keren; Shimon, Ilan

doi:10.1007/s12020-020-02529-5

Cited by 2 publications

(7 citation statements)

References 9 publications

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“…In patients with acromegaly, efficacy/effectiveness assessed by change in IGF-1 and GH values was similar in patients receiving home injections compared with injections in the healthcare setting, across two studies [36,40]. Overall, >85% of participants receiving home injections were reported to achieve normalization or control of IGF-1 and GH in three studies (defined on the basis of studyspecific thresholds; Table S8) [36,38,40].…”

Section: Efficacy and Effectiveness Outcomesmentioning

confidence: 93%

“…Seven studies were observational [33][34][35][36][37][38][39], alongside three interventional trials [40][41][42], and two budget impact models [43,44]. Seven studies were conducted in Europe [33-35, 37, 39-41], two in the US, and one in Israel [36,38,42]. Both budget impact models used a UK perspective [43,44].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Five and six studies evaluated patients with acromegaly [34,36,38,40,42] and NETs, respectively [33,35,37,39,41,44]. One of the budget impact models analyzed SSA usage in both acromegaly and NETs patient populations [43].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Four studies assessed home injection only and did not include a comparison to injections administered in the healthcare setting [33,35,38,42]. The majority of studies evaluated home injection of LAN only (7/12 studies) [33,35,36,38,[40][41][42]. A further four studies investigated patients treated with LAN or OCT [37,39,43,44].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Across the two indications, three clinical trials assessed treatment efficacy [40][41][42], and an additional three realworld evidence studies examined treatment effectiveness (Table 1 and Table S8) [36,38,39].…”

Section: Efficacy and Effectiveness Outcomesmentioning

confidence: 99%

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Evaluating home injection compared with healthcare-setting injection of somatostatin analogs: a systematic literature review

et al. 2022

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Purpose A systematic literature review was conducted to assess the use of home injections (self/partner/healthcare provider [HCP]-administered) of somatostatin analogs (SSAs) as an alternative to healthcare-setting injections in patients with acromegaly and neuroendocrine tumors (NETs). Methods MEDLINE/Embase/the Cochrane Library (2001( -September 2021, key congresses (2019-2021), and bibliographies of relevant systematic reviews were searched. Eligible studies reported on efficacy/effectiveness, safety, adherence, patient-reported outcomes (PROs), and economic outcomes in populations receiving home injections of SSAs. Results Overall, 12 studies were included, all reporting on SSAs (lanreotide Autogel/Depot or octreotide long-acting release) in acromegaly or NETs. Across four studies, home injection was associated with similar disease control in patients with acromegaly/ NETs compared with healthcare-setting administration. High rates of treatment adherence were shown in two studies of patients with acromegaly receiving lanreotide injections at home. Two studies reported non-serious adverse events; incidence of adverse reactions was similar in both the home and healthcare administration settings. Preference for injection setting varied between studies and indications; nonetheless, higher satisfaction/convenience (>75% patients) was reported for home injections. Self-or partnerinjection was associated with economic savings compared with administration in the healthcare setting across five studies. Conclusion Efficacy/effectiveness, adherence, and safety outcomes of SSAs in the home injection setting were similar to those in the healthcare setting, with high reported satisfaction and convenience. Self/partner injection also resulted in cost savings. These findings provide a basis to understand outcomes related to home injection and encourage healthcare providers to discuss optimal treatment choices with their patients. Plain language summaryAcromegaly and neuroendocrine tumors (NETs) are two diseases that affect the production of hormones, leading to a variety of symptoms in different parts of the body. Patients can be treated with medications called somatostatin analogs, which include lanreotide Autogel/Depot (LAN) and octreotide long-acting release (OCT). These treatments are given by injections, usually performed by a doctor or nurse in a healthcare setting such as a hospital or clinic. However, patients can sometimes receive LAN or OCT injections at home by a healthcare professional or-for LAN onlyindependently by a partner or the patient themself. Home injection may be less disruptive for patients and could free up healthcare resources, but there is limited evidence to support the choice. To address this, we reviewed all publications on home injection of somatostatin analogs in the last 20 years, finding 12 relevant studies. Results generally showed that

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Section: Efficacy and Effectiveness Outcomesmentioning

confidence: 93%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Efficacy and Effectiveness Outcomesmentioning

confidence: 99%

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Evaluating home injection compared with healthcare-setting injection of somatostatin analogs: a systematic literature review

et al. 2022

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Development and validation of a novel treatment adherence, satisfaction and knowledge questionnaire (TASK-Q) for adult patients with hypothalamic-pituitary disorders

Llahana,

Yuen

2024

Pituitary

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Purpose Successful treatment outcomes of adults with hypothalamic-pituitary disorders necessitate the adoption of intricate self-management behaviors, yet current scales for evaluating treatment adherence and satisfaction are inadequate for this patient group. This research introduces a novel treatment adherence, satisfaction and knowledge questionnaire (TASK-Q) developed specifically to identify patients’ unmet needs in better assessing and managing these disorders. Methods The study was conducted in three phases: (1) generating items and testing content validity, (2) refining these items through a pilot study, and (3) a main study evaluating the psychometric properties of the TASK-Q scale among 262 adults in a Pituitary Nurse-led Clinic, with 152 (58%) patients completing the questionnaire. Results Exploratory factor analysis was used to test the factor structure and construct validity of the TASK-Q, revealing a 22-item scale divided into Satisfaction and Knowledge (17 items) and Adherence (5 items) subscales, and exhibiting high internal consistency (Cronbach’s α = 0.90). Significant correlations were identified between satisfaction and knowledge (r = 0.67, p < 0.001), satisfaction and adherence (r = 0.23, p = 0.005), and knowledge and adherence (r = 0.43, p < 0.001). Complex treatment regimens, like daily growth hormone injections and adjusting glucocorticoids during illness, negatively affected adherence (p < 0.001). Conclusion The TASK-Q is a novel validated scale that can effectively evaluate patients’ perspectives on adherence, knowledge and satisfaction. Our findings highlight the significant impact of Advanced Nurse Practitioners in improving patient self-management behaviors, which likely leads to better treatment outcomes for people with hypothalamic-pituitary disorders.

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Benefits of a nurse-led home injection service for acromegaly patients treated with somatuline autogel

Cited by 2 publications

References 9 publications

Evaluating home injection compared with healthcare-setting injection of somatostatin analogs: a systematic literature review

Evaluating home injection compared with healthcare-setting injection of somatostatin analogs: a systematic literature review

Development and validation of a novel treatment adherence, satisfaction and knowledge questionnaire (TASK-Q) for adult patients with hypothalamic-pituitary disorders

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