Benefits of a mosaic approach for assessing cortical atrophy in individual multiple sclerosis patients
Marlene Tahedl,
Tun Wiltgen,
Cui Ci Voon
et al.
Abstract:ObjectiveCortical gray matter (GM) atrophy plays a central role in multiple sclerosis (MS) pathology. However, it is not commonly assessed in clinical routine partly because a number of methodological problems hamper the development of a robust biomarker to quantify GM atrophy. In previous work, we have demonstrated the clinical utility of the “mosaic approach” (MAP) to assess individual GM atrophy in the motor neuron disease spectrum and frontotemporal dementia. In this study, we investigated the clinical uti… Show more
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