Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants

Laccourreye, O.; Werner, A.; Giroud, Jean‐Paul; Couloigner, V.; Bonfils, P.; Bondon‐Guitton, Emmanuelle

doi:10.1016/j.anorl.2014.11.001

Cited by 60 publications

(42 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore the US Food and Drug Administration has issued a warning against the use of over-the-counter cough and cold products in children younger than 4 years of age. 9 Furthermore, the use of decongestants should be minimized, especially in children, 10 whereas codeine has been restricted in children by the European Medical Agency since 2015. 11 Selective COX inhibitors, such as celecoxib and mesalazine, have been widely used in clinics for their antipyretic, analgesic, and antiinflammatory properties in patients with airway diseases, 12 whereas their combination with neuraminidase inhibitors (NAIs) has significantly improved the survival of IFV-infected mice.…”

Section: Treatment Symptom Medicationsmentioning

confidence: 99%

Promising approaches for the treatment and prevention of viral respiratory illnesses

Papadopoulos

Megremis

Kitsioulis

et al. 2017

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory tract infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission, or even just the symptoms. Strategies targeting all these aspects are developing concurrently, and several novel and promising approaches are emerging. In this perspective we overview the entire range of options and highlight some of the most promising approaches, including new antiviral agents, symptomatic or immunomodulatory drugs, the re-emergence of natural remedies, and vaccines and public health policies toward prevention. Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses.

show abstract

Section: Treatment Symptom Medicationsmentioning

confidence: 99%

Promising approaches for the treatment and prevention of viral respiratory illnesses

Papadopoulos

Megremis

Kitsioulis

et al. 2017

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…These neurological symptoms happen in the absence of any relevant history. 31 Toxic effect on the heart ES acts as epinephrine-like substance and stimulates the heart. It has been confirmed that ephedra can increase blood pressure and stress the circulation which leads to serious conditions such as stroke, infarction, and other heart complications.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, ephedrine applied to the nasal mucosa reduces nasal congestion more strongly and quickly than oral pseudoephedrine but with a short duration of action. 31…”

Section: Liver Toxicitymentioning

confidence: 99%

Clinical uses and Toxicity of Ephedra sinica: An Evidence-Based Comprehensive Retrospective Review (2004-2017)

saeed¹,

Dhamen²,

Ahmad³

et al. 2019

View full text Add to dashboard Cite

Background: Ephedra sinica (ES) (Ma-huang) is a well-known plant due to its widespread therapeutic uses. However, many adverse effects such as hepatitis, nephritises, and cardiovascular toxicity have been reported for this plant. Few of these side effects are reversible whereas others are irreversible and may even lead to death. Aim of the Study: The aim of this study was to investigate the clinical uses and toxicity cases/consequences associated with the use of ES. The review will compare and evaluate the cases reported for ES and identify the causes which make the plant a poisonous one. Materials and Methods: An extensive literature review was conducted from 2004 to 2017, and research literature regarding the clinical cases were collected using databases and books such as Google Scholar, Science Direct, Research gate, PubMed, and Web of Science/Thomson Reuters whereas the keywords searched were "Ephedra sinica, " clinical cases of Ephedra sinica, "Ma-hung poisonous, " "Ma-hung toxicity reported cases and treatment, " and "Ephedra Sinica toxicity reported cases and treatment. " Results: eleven different cases were identified which met the eligibility criteria and were studied in detail to extract out the findings. It turned out that most of the patients and participants developed adverse side effects following the use of ES, and after a proper course of treatment or trail, some of the side effects were reversible, whereas others were found irreversible. The most common adverse effects and toxicity observed in patients were liver problems, renal failures, and cardiac toxicity which resulted in two mortalities whereas the other two got recovered. On an in-depth study, it was revealed that most of the toxicities in such cases were associated with the use of ES in combination with other conventional drugs, long-term use, or use in patients with cardiac and renal problems without a medical supervision. Conclusion: Hence, it is concluded that ES may have reversible as well as irreversible adverse effects and may even result in death; however, the use of a plant with the proper knowledge and under sound medical supervision may reduce such exaggerations.

show abstract

“…popularne preparaty "na katar", zawierające w swoim składzie pseudoefedrynę (pochodną amfetaminy), powinny być wydawane z apteki ze szczególną ostrożnością [20][21]. Warto zaznaczyć, że w światowym piśmiennictwie sugeruje się konieczność wycofania preparatów pseudofedryny ze sprzedaży OTC z uwagi na możliwość wystąpienia trudnych do przewidzenia, ciężkich działań niepożądanych o charakterze neurologicznym lub sercowo-naczyniowym, które mogą pojawić się nawet po zastosowaniu niskich dawek, u pacjentów, bez wcześniej zdiagnozowanych chorób w obrębie tych układów [21]. Warto również zaznaczyć, że wytyczne Francuskiego Towarzystwa Otolaryngologicznego wskazują, że leki te nie powinny być stosowane u pacjentów poniżej 15 roku życia [21].…”

Section: Wstępunclassified

“…Pierwszym była próba oceny, czy personel fachowy apteki ma świadomość, że ekspedycja pseudoefedryny powinna być poprzedzona szczególnie starannym rozpoznaniem i/lub ostrzeżeniem dotyczącym możliwości wystąpienia działań niepożądanych (DN) indukowanych przez tę substancję. Upraszczając można zadać pytanie, czy farmaceuci/technicy farmaceutyczni sprzedając lek uwzględniają fakt, że zgodnie z danymi literaturowymi ryzyko związane z zastosowaniem pseudoefedryny może przewyższać ewentualną korzyść terapeutyczną [21]. Oceniano również, czy ekspedycji preparatu "na Tabela 3.…”

Section: Dyskusja Wynikówunclassified

An assessment of counseling quality provided by community pharmacies to patients during expedition of pseudoephedrine

Gołda¹,

Dymek²,

Polak³

et al. 2019

Farm Pol.

View full text Add to dashboard Cite

An assessment of counseling quality provided by community pharmacies to patients during expedition of pseudoephedrine • The study was designed to investigate the quality of pharmaceutical counseling accompanying the expedition of pseudoephedrine. Method: the "mystery patient" study carried out in 142 community pharmacies in Poland. The study was conducted using two scenarios and a checklist. The scenario I: drug for child, II: 75-year-old man. In both situations, the pharmacy staff should discourage the use of the drug. The checklists were completed after leaving the pharmacy. The data were analyzed collectively. It was assessed whether the pharmacists/ technicians identify the drug user and/or exclude contraindications. Results: 142 consultations were analyzed (I n=72, II n=70). Only 24 out of 142 pharmacists/technicians identified the patient. Scenario I: 21 pharmacists did not ask any questions. Scenario II: only 22% pharmacists/technicians informed that the drug is for the "elderly person" determined his age, 50% of consultants did not ask about diseases/other medicines used by him. Conclusions: It is necessary to educate pharmacists about conducting interviews and introducing algorithms for the expedition of OTC drugs.

show abstract

Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants

Cited by 60 publications

References 23 publications

Promising approaches for the treatment and prevention of viral respiratory illnesses

Promising approaches for the treatment and prevention of viral respiratory illnesses

Clinical uses and Toxicity of Ephedra sinica: An Evidence-Based Comprehensive Retrospective Review (2004-2017)

An assessment of counseling quality provided by community pharmacies to patients during expedition of pseudoephedrine

Contact Info

Product

Resources

About